Association of IL6 single nucleotide polymorphisms with febrile seizures

Single nucleotide polymorphisms of TNF-Α gene in febrile seizures

“…Informed consent was obtained from the parents of each individual before blood sampling, and the study was approved by the Ethics Committee of Tehran University of Medical Sciences. The study involved 78 children, aged 6 months to 6 years, with a history of FS, and 137 control subjects without a history of any diseases [25]. Diagnosis of FS followed the criteria established in the 1989 International Classification of Epileptic Syndromes.…”

“…Cytokine genotyping was performed, using polymerase chain reaction with sequence-specific primers (PCR-SSP assay kit, Heidelberg University), as explained before [25]. The frequencies of alleles, genotypes, and haplotypes of TNF-α at positions −308 and − 238 were recorded.…”

“…We have recently shown that there is a significant association between the presence of the +565A of IL-6, −590 C of IL-4, codon 10/CT (rs1982037) TGF-β and FS [25][26][27]. This study was performed to determine the associations between SNPs of TNF-α and FS in a group of Iranian patients.…”

Seizures and Epilepsies due to Channelopathies and Neurotransmitter Receptor Dysfunction: A Parallel between Genetic and Immune Aspects

“…Inflammatory response components, such as those involved in the interleukin 1 (IL-1) system, have been suspected to play a role in FS [Gatti et al, 2002]. Recent reports indicate that certain SNPs in genes that encode other inflammation-related molecules, such as IL-6 [Shahrokhi et al, 2014], IL-6 receptor, prostaglandin E receptor 3, purinergic receptor P2X7, or TLR-4, may be involved in the pathogenesis of FS [Emsley et al, 2014].…”

Association of TGFB, but not IL10, single nucleotide polymorphisms with febrile seizures

“…Several studies showed interaction between immune inflammatory system, cytokines and genetic factors, which are involved in FS [7][8][9][10][11][12].…”