Association of TGFB, but not IL10, single nucleotide polymorphisms with febrile seizures

Shahrokhi, Amin; Zare-Shahabadi, Ameneh; Soltani, Shahin; Soleimani, Farin; Vameghi, Roshanak; Konjkav, Arian Rahimi; Karimi, Parviz; Katibeh, Pegah; Vafaei, Mohammad; Zoghi, Samaneh; Ashrafi, Mahmoud Reza; Rezaei, Nima

doi:10.1016/j.seizure.2015.05.001

Cited by 12 publications

(12 citation statements)

References 36 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…We have recently shown that there is a significant association between the presence of the +565A of IL-6, −590 C of IL-4, codon 10/CT (rs1982037) TGF-β and FS [25][26][27]. This study was performed to determine the associations between SNPs of TNF-α and FS in a group of Iranian patients.…”

Section: Introductionmentioning

confidence: 99%

Single nucleotide polymorphisms of TNF-Α gene in febrile seizures

Zare-Shahabadi

Ashrafi

Shahrokhi

et al. 2015

Journal of the Neurological Sciences

Self Cite

View full text Add to dashboard Cite

Section: Introductionmentioning

confidence: 99%

Single nucleotide polymorphisms of TNF-Α gene in febrile seizures

Zare-Shahabadi

Ashrafi

Shahrokhi

et al. 2015

Journal of the Neurological Sciences

Self Cite

View full text Add to dashboard Cite

“…In our study, the haplotype frequencies of IL-10-592C/-819C/-1082A/-1352G were also decreased in patient group with FS, FS+, and GEFS+ compared to controls, although statistically insignificant (18.5% vs. 24.5%, P = 0.497). In contrast, Iranian FS study reported that IL-10-592, -819, and -1082 showed no significant allelic association [11].…”

Section: Discussionmentioning

confidence: 78%

“…Japanese FS study showed significant lower frequencies of the IL-10-592C/-819C/-1082A haplotype than controls [10]. In contrast, IL-10-592, -819, and -1082 showed no significant allelic association in Iranian FS study [11].…”

Section: Introductionmentioning

confidence: 71%

Association of Tumor Necrosis Factor-α Gene Promotor Variant, Not Interleukin-10, with Febrile Seizures and Genetic Epilepsy with Febrile Seizure Plus

Choi

Kim

et al. 2019

Ann Child Neurol

View full text Add to dashboard Cite

Purpose: Cytokines demonstrate active roles in the occurrence of febrile seizures (FS). However, whether a genetic predisposition to inflammation is implicated in FS, febrile seizure plus (FS+) or genetic epilepsy with febrile seizure plus (GEFS+) are still unclear. Therefore we perform this study to find the association of promotor variants in pro-inflammatory cytokine tumor necrosis factor-α (TNF-α) genes and anti-inflammatory cytokine interleukin 10 (IL-10) genes either with FS, FS+, and GEFS+ in Korean children. Methods: Fifty-seven children with FS, 32 FS+, and 12 GEFS+ patients were compared with 108 controls. The allelic and genotypic distributions were compared for TNF-α-238 (rs361525),-308 (rs1800629),-857 (rs1799724),-863 (rs1800630), and IL-10-592 (rs1800872),-819 (rs1800871),-1082 (rs1800896), and-1352 (rs1800893). Results: Allelic and genotypic frequencies of TNF-α and IL-10 promotor variants showed no significant differences between FS, FS+, and GEFS+ versus controls. However, AA genotypes at TNF-α-863 were present only in controls. TNF-α-863 (rs1800630) promoter variants showed an association with FS, FS+, and GEFS+ in a recessive mode of inheritance pattern (P<0.05). Conclusion: Our results suggest that AA genotypes at TNF-α-863 may be associated with FS, FS+, and GEFS+, implicating protective roles against to development of FS, FS+, and GEFS+.

show abstract

“…Furthermore, it may play a neuroprotective role in the case of prolonged convulsions, protecting nerve cells against ischaemic damage (3) . Interleukin 10 (IL-10) inhibits the production of proinflammatory cytokines, including TNF-α, IL-1, IL-6 and IL-8, and its increased levels observed in experimental studies after the onset of a seizure may indicate (20,23) . Literature data on the relationship between IL-10 and other cytokines (including IL-2, IL-4, IL-8, TNF-α) and FS are inconclusive (3,20) .…”

Section: Immune Factors -Cytokinesmentioning

confidence: 99%

Aetiology of febrile seizures – a problem not fully understood

Grzywna-Rozenek¹,

Barć-Czarnecka²,

Machura³

2021

Pediatr Med Rodz

View full text Add to dashboard Cite

Febrile seizures are seizures that occur during febrile illnesses in the absence of central nervous system infection or other identifiable aetiology in children who have never had any non-febrile seizures before. Although the condition is quite common, affecting 2–5% of children between 3 months and 5 years of age, the underlying pathomechanism is not fully explained. Immaturity of the nervous system, as well as environmental, genetic and immune factors are contemplated. Viruses are the main aetiological factor of febrile infections accompanied by seizures. The risk of febrile seizures after vaccination is low and may be associated with the child’s genetic predisposition. Deficiency of trace elements, including zinc and iron, may also promote seizures. The association between febrile seizures and vitamin D levels was reported in only few studies. It seems that genetic background plays an important role, at least in some cases. In recent years, particular attention has been paid to the possible involvement of immune factors, including pro- and anti-inflammatory cytokines. Previous studies on the aetiology of febrile seizures confirmed their multifactorial nature and indicated their heterogeneity within this group of patients. Further research may not only contribute to a better understanding of the mechanisms underlying the pathogenesis of febrile seizures, but also determine the direction of actions that may reduce the risk of their occurrence and/or recurrence.

show abstract

Association of TGFB, but not IL10, single nucleotide polymorphisms with febrile seizures

Abstract: Certain alleles, genotypes, and haplotypes in TGFB genes were over represented in patients with FS, which possibly could predispose individuals to this disease.

Cited by 12 publications

References 36 publications

Single nucleotide polymorphisms of TNF-Α gene in febrile seizures

Single nucleotide polymorphisms of TNF-Α gene in febrile seizures

Association of Tumor Necrosis Factor-α Gene Promotor Variant, Not Interleukin-10, with Febrile Seizures and Genetic Epilepsy with Febrile Seizure Plus

Aetiology of febrile seizures – a problem not fully understood

Contact Info

Product

Resources

About