Association of IL-21 polymorphisms (rs907715, rs2221903) with susceptibility to multiple autoimmune diseases: A meta-analysis

Liu, Jie; Cen, Han; Ni, Jing; Zhang, Min; Li, Peng; Yang, Xiao‐Ke; Leng, Rui‐Xue; Pan, Hai‐Feng; Ye, Dong-Qing

doi:10.3109/08916934.2014.944262

Cited by 11 publications

(6 citation statements)

References 37 publications

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“…Despite the normal functions, IL-4 and IL-21 are highly involved in the progression of autoimmune diseases. The genetic associations between IL-4/IL-21 and autoimmune diseases had been well documented (22)(23)(24)(25)(26)(27)(28)(29)(30)(31)(32)(33). Furthermore, elevated IL-4/IL-21 serum levels and increased numbers of IL-4/IL-21 producing T cells were observed in several human autoimmune conditions (34)(35)(36)(37)(38)(39)(40)(41)(42).…”

Section: Introductionmentioning

confidence: 99%

Interleukins 4 and 21 Protect Anti-IgM Induced Cell Death in Ramos B Cells: Implication for Autoimmune Diseases

Hui¹,

Wu²,

Leung³

2022

Front. Immunol.

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Interleukins 4 (IL-4) and 21 (IL-21) belong to the common gamma chain cytokine family which are highly involved in the progression of autoimmune diseases. While IL-4 is well known to be involved in the suppression of apoptosis of autoreactive B cells, the role played by IL-21 remains unclear. In the current study, we activated the human Burkitt’s lymphoma Ramos B cells with anti-IgM to mimic B cell hyperactivation observed in patients of autoimmune diseases. Consistent with other reported findings, anti-IgM led to the downregulation of proteins involved in B cell survival and proliferation, as well as the activation of caspase 3 activity and DNA damage, resulting in apoptotic cell death after 48-hour treatment. Although both IL-4 and IL-21 reversed anti-IgM-induced apoptosis and cell cycle arrest, they did so via different mechanisms: while IL-4 could directly suppress anti-IgM-induced caspase 3 activation and marker indicative of DNA damage, IL-21 could induce B cell proliferation in the presence of anti-IgM. Importantly, IL-21 also suppressed activation induced cell death in human primary B cells. Pre-treatment with clinically validated JAK inhibitors completely reversed the effects of IL-4 and IL-21 to rescue anti-IgM induced cell death and DNA damage. The results indicate the underlying mechanisms of how IL-4 and IL-21 differentially promote survival of hyperactivated B cells and provide hints to treat autoimmune diseases.

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Section: Introductionmentioning

confidence: 99%

Interleukins 4 and 21 Protect Anti-IgM Induced Cell Death in Ramos B Cells: Implication for Autoimmune Diseases

Hui¹,

Wu²,

Leung³

2022

Front. Immunol.

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“…Otherwise, a fixed-effect model (the Mantel Haenszel method) was adopted. 10 The weight given to each study is chosen to be inverse of the variance of the effect estimate. Due to some studies using the median and interquartile range (IQR) value for reporting the age, operative time and length of day (length of stay [LOS]), we adopted the mathematical method used by Wan et al 11 to estimate the mean value and standard deviation from the sample size, median, range and/or IQR.…”

Section: Methodsmentioning

confidence: 99%

Predictors of Readmission After Pulmonary Resection in Patients With Lung Cancer: A Systematic Review and Meta-analysis

Liu

Yang

Liu

et al. 2022

Technol Cancer Res Treat

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Objective: Postoperative readmissions are considered an indicator of healthcare quality. The purpose of this study was to assess the factors associated with readmission following pulmonary resection for lung cancer. Methods: A comprehensive search was performed in PubMed, Web of science, the Cochrane Library, and databases of CNKI and Wanfang. We collected the factors associated with readmission following pulmonary resection from the included studies, and data analysis was conducted with STATA SE12.0 software. Results: A total of 11 studies (386 012 participants) were included. The meta-analysis results showed that age (standardized mean difference [SMD] = 0.093), male sex (odds ratio [OR] = 1.260), Charlson score (SMD = 1.408), forced expiratory volume in 1 second predicted (SMD = −0.203), congestive heart failure (OR = 1.708), peripheral vascular disease (OR = 1.436), and histology (OR = 0.804) were associated with readmission ( P < .05), while hypertension was not. Patients with postoperative empyema, pneumonia, air leak, and arrhythmia (all P < .05) had higher odds of hospital readmission. Conclusion: The predictive factors for readmission can help in establishing individualized discharge and follow-up plans and programs for reducing hospital readmissions after pulmonary resection in patients with lung cancer.

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“…Though there have been many advances in the development of antibiotics and supportive care, sepsis remains a serious and deadly problem with high mortality rates worldwide (Martin et al, 2003;Zhang et al, 2014). Cytokines play vital roles in the regulation of host immune response, and altered expression of cytokines is proven to be involved the development of sepsis (Stanilova, 2010;Teuffel et al, 2010;Grealy et al, 2013).…”

Section: Introductionmentioning

confidence: 98%

“…It is a potent immune modulatory cytokine with pleiotropic effects on both innate and adaptive immune responses (Liu et al, 2014). It exerts a variety of effects on the immune system and has an important role in B cell responsiveness, proliferation, plasma cell differentiation, and immunoglobulin production, and augments CD8 + T cell and NK cell activity (Ozaki et al, 2004;Kuchen et al, 2007;Messaoudi et al, 2011).…”

Section: Introductionmentioning

confidence: 98%

Association between polymorphisms inIL21gene and risk for sepsis

Miao

Zhou

et al. 2016

Biomarkers

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Association of IL-21 polymorphisms (rs907715, rs2221903) with susceptibility to multiple autoimmune diseases: A meta-analysis

Abstract: Data from the present study suggest that the IL-21 rs907715 polymorphism might be associated with multiple ADs susceptibility in Caucasians. Especially, the allele G of intronic rs907715 in IL-21 confers increased risk of ADs.

Cited by 11 publications

References 37 publications

Interleukins 4 and 21 Protect Anti-IgM Induced Cell Death in Ramos B Cells: Implication for Autoimmune Diseases

Interleukins 4 and 21 Protect Anti-IgM Induced Cell Death in Ramos B Cells: Implication for Autoimmune Diseases

Predictors of Readmission After Pulmonary Resection in Patients With Lung Cancer: A Systematic Review and Meta-analysis

Association between polymorphisms inIL21gene and risk for sepsis

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