Association of PCSK1 gene polymorphisms with abdominal fat content in broilers

Abstract

Protein proteolytic enzymes (Proprotein Convertase, PC) is a Ca 2+-dependent serine protease family, whose main function is to cleave precursors of biologically inactive proteins or peptide chains into active functional molecules. Proprotein convertase subtilisin/kexin type 1 (PCSK1) gene is mainly expressed in nerve and endocrine tissues. In this study, PCSK1 was selected as an important candidate gene for abdominal fat content in broilers. We cloned the exon region of chicken PCSK1 gene and found six single-nucleotide polymorphisms (SNPs). Association analysis was carried out and we found that the polymorphisms of these six SNPs were significantly associated

Genome-Wide Association Study Revealed the Effect of rs312715211 in ZNF652 Gene on Abdominal Fat Percentage of Chickens

“…According to the database, 292 QTLs and numerous SNPs were located in abdominal fat traits [ 2 ]. These QTLs and SNPs were verified in several broiler breeds and were significantly associated with fat deposition [ 29 , 30 ]. We attempted to identify the major genetic markers related to abdominal fat and growth traits in broilers.…”

Polymorphisms of KLF3 gene coding region and identification of their functionality for abdominal fat in chickens

“…In addition, there were significant differences between the two lines in allele frequencies of these three SNPs (Table 2) ( p < 0.01). Generally speaking, artificial selection for important traits of domesticated animals is accompanied with alteration of allele frequencies of gene, frequencies of the alleles favourable for human are more likely to be increased, whereas unfavourable alleles tend to be decreased (Zhou et al., 2020). NEAUHLF used in the present study has been divergently selected for AFP since 1996, exhibiting significant differences in AFP after 4th generation.…”

GPNMB promotes abdominal fat deposition in chickens: genetic variation, expressional profile, biological function, and transcriptional regulation

“…Therefore, controlling the excessive abdominal fat deposition is an important long-term goal of native chicken breeding. Over the past several decades, though a number of candidate genes and genetic variations that could potentially affect fat deposition have been identified by different genetic analysis approaches in various chicken populations ( Jin et al, 2017 ; Chen et al, 2019 ; Mu et al, 2019 ; Na et al, 2019 ; Xing et al, 2020 ; Zhou et al, 2020 ; Wang et al., 2021a ; Wang et al., 2021b ; Xing et al, 2021 ; Yuan and Lu, 2021 ), the mechanisms underlying the abdominal fat deposition still remain poorly understood in chickens.…”