GPNMB promotes abdominal fat deposition in chickens: genetic variation, expressional profile, biological function, and transcriptional regulation

Genome-wide association studies of the fatty acid composition of Korean native chicken breast meat

“…Additionally, GPNMB overexpression significantly increased the expression of the FASN, SCD, ACACA, ACSL1, SREBP1, and PLIN2 genes, involved in the synthesis of different fatty acid [27]. The GPNMG gene might be a useful genetic marker in poultry breeding for fatty acid profiles.…”

“…GPNMB gene, which is involved in melanin deposition, bone mineral deposition, regulation of inflammation, and lipid metabolism [27]. The GPNMB gene SNP (rs31126482) was reported to be linked with the weight of abdominal fat [27].…”

“…The GPNMG gene might be a useful genetic marker in poultry breeding for fatty acid profiles. Insulin-like growth factor binding protein-3 (IGF2BP3) is a RNAbinding protein that controls IGF2 expression [27]. IGF2BP3 is also associated with IMF deposition in chickens [28].…”