Association of <i>NQO1</i> levels and its genetic polymorphism with susceptibility to methamphetamine dependence

Liu, Huan; Zhang, Wei; Deng, Xiaodong; Ma, Ying; Liu, Yun

doi:10.1002/mgg3.1789

Cited by 3 publications

(2 citation statements)

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“…Our Smk PWAS prioritized 5 causal genes, 3 of which (also supported by the TWAS) play roles in synaptic plasticity (SRR) 38,39 , neurodevelopment (NT5C2) 40,41 , and brain oxidative stress (NQO1) 42 . SRR encodes serine racemase, the enzyme that converts L-to D-serine, a coactivator of N-methyl-D-aspartate receptors (NMDAR), a key component in glutamatergic synaptic signaling in the brain 38,39 .…”

Section: Discussionmentioning

confidence: 98%

Integrating Human Brain Proteomic Data with Genome-Wide Association Study Findings Identifies Novel Brain Proteins in Substance Use Traits

Toikumo

Kember

et al. 2022

Preprint

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Background: Despite the growing number of genetic risk loci identified for substance use traits (SUTs), the impact of these loci on protein abundance and their potential as therapeutic targets are unknown. Methods: To address this, we performed a proteome-wide association study (PWAS) by integrating human brain proteomes from discovery (Banner; N = 152) and validation (ROSMAP; N = 376) datasets with genome-wide association study (GWAS) summary statistics for 4 SUTs. The sample comprised 4 GWAS of European-ancestry individuals for smoking initiation [Smk] (N = 1,232,091), alcohol use disorder [AUD] (N = 313,959), cannabis use disorder [CUD] (N = 384,032), and opioid use disorder [OUD] (N = 302,585). We conducted transcriptome-wide association studies (TWAS) with human brain transcriptomic data to examine the overlap of genetic effects at the proteomic and transcriptomic levels and tested significant genes for causality through Colocalization analysis. Results: Twenty-seven genes (Smk=21, AUD=3, CUD=2, OUD=1) were significantly associated with cis-regulated brain protein abundance. There was evidence for causality in 6 genes (Smk: NT5C2, GMPPB, NQO1, SRR, and ACTR1B; AUD: CTNND1), which act by regulating brain protein abundance. Cis-regulated transcript levels for 8 genes (Smk=6, CUD=1, OUD=1) were associated with SUTs, indicating that genetic loci could confer risk for these SUTs by modulating both gene expression and proteomic abundance. Conclusions: Functional studies of the high-confidence risk proteins (SRR for Smk and CTNND1 for AUD) identified here are needed to determine whether they are modifiable targets and useful in developing medications and biomarkers for these SUTs.

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Section: Discussionmentioning

confidence: 98%

Integrating Human Brain Proteomic Data with Genome-Wide Association Study Findings Identifies Novel Brain Proteins in Substance Use Traits

Toikumo

Kember

et al. 2022

Preprint

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“…Emerging evidence suggests that HDL function is more important than quantity, and HDL-C may no longer be a reliable marker for cardiovascular diseases (49). Potential damage to vascular function arises from long-term drug abuse (50).…”

Section: Discussionmentioning

confidence: 99%

Effects of an 8-week Baduanjin intervention combined with low-carbohydrates diet among overweight people who struggle with drug addiction

Jia

2022

Front. Public Health

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BackgroundPrior studies have consistently revealed that a combination of physical activity with caloric restriction results in a reduction in body weight in the general population. Both overweight and drug abuse are risk factors for poor physiological health, and poor mental health has been associated with drug abuse and unhealthy body mass index (BMI). However, the effects of low-carbohydrates diet (LC) combined with mind-body exercise intervention on improving anthropometric characteristics, lipid metabolism, quality of life, and craving among overweight people who struggle with drug addiction have yet to be clarified.MethodsFifty-four eligible male patients were randomly assigned to the control group (CON; n = 18), the Baduanjin intervention group (BA, 60 min × 5 times/week, 8 weeks; n = 18), and the Baduanjin combined with LC intervention group (LC; n = 18). We compared the anthropometric characteristics, blood biochemical parameters, quality of life, and drug craving responses between the three groups at baseline (week 0), week 4, and week 8.ResultsAfter repeated measurements in the general linear model, both the BA and LC groups exerted significant effects on decreasing waist circumference, BMI, body weight, hip circumference, body fat percentage, total cholesterol level, and triglyceride level (P < 0.05). There was no significant difference in the HDL-C level observed among the BA and LC groups at 8 weeks (P > 0.05); however, there was an overall upwards trend. A significant change in trends in the quality of life scale score was determined in the three groups (P < 0.001). The three groups showed reductions in visual analog scale score distribution over time (P < 0.05).ConclusionsEither Baduanjin or an 8-week Baduanjin combined with LC can significantly reduce anthropometric characteristics and body composition, enhance the quality of life, and reduce craving in overweight/obese patients. Baduanjin combined with LC is particularly effective in improving lipid metabolism.

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Association of NQO1 levels and its genetic polymorphism with susceptibility to methamphetamine dependence

Liu

Zhang

Deng

et al. 2021

Molec Gen & Gen Med

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Association of NQO1 levels and its genetic polymorphism with susceptibility to methamphetamine dependence

Abstract: This is an open access article under the terms of the Creat ive Commo ns Attri bution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

Cited by 3 publications

References 44 publications

Integrating Human Brain Proteomic Data with Genome-Wide Association Study Findings Identifies Novel Brain Proteins in Substance Use Traits

Integrating Human Brain Proteomic Data with Genome-Wide Association Study Findings Identifies Novel Brain Proteins in Substance Use Traits

Effects of an 8-week Baduanjin intervention combined with low-carbohydrates diet among overweight people who struggle with drug addiction

Association of NQO1 levels and its genetic polymorphism with susceptibility to methamphetamine dependence

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