Abstract:Background: Subacute sclerosing panencephalitis is a progressive neurodegenerative disease that is a late complication of measles infection. However, to date, the pathogenesis of subacute sclerosing panencephalitis is still not explained; both viral and host factors seem to be associated. The present study aimed to investigate the relationship between NOD1 and NOD2 gene variants and subacute sclerosing panencephalitis. Methods: The gene variants of NOD1 (rs2075820 and rs2075818) and NOD2 (R334Q and R334W) were… Show more
“…Interestingly, a case-control study found a genetic polymorphism in the NOD1 gene to be protective against SSPE. This is further attributed to a reduced capacity for the nod-like receptor encoded by this gene to activate NF-κB signalling upon recognition of pathogen-associated molecular patterns (50). It is possible that in SSPE, long-term diffuse activation of NF-κB, and thus chronic inflammation, may underlie the development and spread of tauopathy in genetically-vulnerable individuals.…”
“…Interestingly, a case-control study found a genetic polymorphism in the NOD1 gene to be protective against SSPE. This is further attributed to a reduced capacity for the nod-like receptor encoded by this gene to activate NF-κB signalling upon recognition of pathogen-associated molecular patterns (50). It is possible that in SSPE, long-term diffuse activation of NF-κB, and thus chronic inflammation, may underlie the development and spread of tauopathy in genetically-vulnerable individuals.…”
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