Chronic effects of inflammation on tauopathies

Langworth-Green, Connor; Patel, Saisha; Jaunmuktane, Zane; Jabbari, Edwin; Morris, Huw; Thom, Maria; Lees, Andrew J.; Zandi, Michael S; Duff, Karen

doi:10.1016/s1474-4422(23)00038-8

Cited by 26 publications

(15 citation statements)

References 103 publications

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“…The heightened interest in tau protein research may be attributed to recent breakthroughs or advancements in this field ( Luciani et al, 2023 ; Zhang Z. Y. et al, 2023 ; Singh et al, 2024 ). Scientists have recently unveiled novel mechanisms or identified promising targets associated with tau pathology that could potentially revolutionize our understanding and treatment approaches for neurodegenerative diseases ( Kim et al, 2023 ; Kyalu Ngoie Zola et al, 2023 ; Langworth-Green et al, 2023 ). Moreover, it is noteworthy that high citation counts not only reflect scientific interest but also establish credibility within the academic community, serving as a fundamental pillar of research in this field ( Nielsen and Andersen, 2021 ; Radosic and Diener, 2021 ).…”

Section: Discussionmentioning

confidence: 99%

“…Neuroinflammation refers to the activation of immune responses within the CNS, specifically involving glial cells such as microglia and astrocytes. Recent studies have demonstrated that neuroinflammation, particularly involving glial cells, plays a pivotal role in the development of tau pathology, providing valuable insights for future investigations and therapeutic interventions targeting tau in AD ( Chen and Yu, 2023 ; Dutta et al, 2023 ; Langworth-Green et al, 2023 ; Lau et al, 2023 ; Lee et al, 2023 ).…”

Section: Discussionmentioning

confidence: 99%

“…However, under certain pathological conditions, tau protein may form paired helical filaments (PHFs) and neurofibrillary tangles (NFTs) through aggregation ( Ossenkoppele et al, 2022 ). These structures have been documented in many neurological diseases collectively termed “tauopathy,” including Alzheimer’s disease (AD) ( Seidler et al, 2022 ; Chang et al, 2024 ), Pick disease (PD) ( Schweighauser et al, 2023 ), progressive supranuclear palsy (PSP) ( Darricau et al, 2023 ), frontotemporal dementia with parkinsonism-17 (FTDP-17), and so on ( Langworth-Green et al, 2023 ; Wang et al, 2023 ). AD is the most extensively researched among these conditions, and as a leading cause of dementia and mortality in older adults, it has emerged as a major public health concern and challenge globally ( Mattsson-Carlgren et al, 2023 ; Mummery et al, 2023 ).…”

Section: Introductionmentioning

confidence: 99%

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Top 100 most-cited articles on tau protein: a bibliometric analysis and evidence mapping

Chen,

Shan,

Wang

et al. 2024

Front. Neurosci.

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BackgroundTau, a microtubule-associated protein extensively distributed within the central nervous system (CNS), exhibits close associations with various neurodegenerative disorders. Here, we aimed to conduct a qualitative and quantitative bibliometric study of the top 100 most-cited publications on tau protein and reveal the current research hotspots and future perspectives.MethodsThe relevant literature was retrieved from the Web of Science Core Collection. CiteSpace (v6.2.R4) and VOSviewer (1.6.19) were adopted for bibliometric analysis with statistical and visual analysis.ResultsCitations per article ranged from 615 to 3,123, with a median number of 765.5 times. “Neuroscience” emerged as the most extensively researched subject in this field. The USA has emerged as the leading country, with a publication record (n = 65), total citations (n = 66,543), strong centrality (0.29), and extensive international collaborations. Harvard University (n = 11) and the University of California, San Francisco (n = 11) were the top two institutions in terms of publications. Neuron dominated with 13 articles in the 37 high-quality journals. M. Goedert from the MRC Laboratory of Molecular Biology was the most productive (n = 9) and top co-cited (n = 179) author. The most frequently studied keywords were Alzheimer’s disease (n = 38). Future research is anticipated to intensify its focus on the pathogenesis of various tau-related diseases, emphasizing the phosphorylation and structural alterations of tau protein, particularly in Alzheimer’s disease.ConclusionThe pathogenesis of various tau-related diseases, including the phosphorylation and structural alterations of the tau protein, will be the primary focus of future research, with particular emphasis on Alzheimer’s disease as a central area of investigation.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Hotspots and trends of microglia in Alzheimer's disease: a bibliometric analysis during 2000–2022

Zhang,

Yao,

et al. 2024

Eur J Med Res

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Background Alzheimer's disease is one common type of dementia. Numerous studies have suggested a correlation between Alzheimer's disease and inflammation. Microglia mainly participate in the inflammatory response in the brain. Currently, ample evidence has shown that microglia are closely related to the occurrence and development of Alzheimer's disease. Objective We opted for bibliometric analysis to comprehensively summarize the advancements in the study of microglia in Alzheimer's disease, aiming to provide researchers with current trends and future research directions. Methods All articles and reviews pertaining to microglia in Alzheimer's disease from 2000 to 2022 were downloaded through Web of Science Core Collection. The results were subjected to bibliometric analysis using VOSviewer 1.6.18 and CiteSpace 6.1 R2. Results Overall, 7449 publications were included. The number of publications was increasing yearly. The United States has published the most publications. Harvard Medical School has published the most papers of all institutions. Journal of Alzheimer’s Disease and Journal of Neuroscience were the journals with the most studies and the most commonly cited, respectively. Mt Heneka is the author with the highest productivity and co-citation. After analysis, the most common keywords are neuroinflammation, amyloid-beta, inflammation, neurodegeneration. Gut microbiota, extracellular vesicle, dysfunction and meta-analysis are the hotspots of research at the present stage and are likely to continue. Conclusion NLRP3 inflammasome, TREM2, gut microbiota, mitochondrial dysfunction, exosomes are research hotspots. The relationship between microglia-mediated neuroinflammation and Alzheimer's disease have been the focus of current research and the development trend of future research.

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Alzheimer's disease genetic pathways impact cerebrospinal fluid biomarkers and imaging endophenotypes in non‐demented individuals

Lorenzini,

Collij,

Tesi

et al. 2024

Alzheimer's & Dementia

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INTRODUCTIONUnraveling how Alzheimer's disease (AD) genetic risk is related to neuropathological heterogeneity, and whether this occurs through specific biological pathways, is a key step toward precision medicine.METHODSWe computed pathway‐specific genetic risk scores (GRSs) in non‐demented individuals and investigated how AD risk variants predict cerebrospinal fluid (CSF) and imaging biomarkers reflecting AD pathology, cardiovascular, white matter integrity, and brain connectivity.RESULTSCSF amyloidbeta and phosphorylated tau were related to most GRSs. Inflammatory pathways were associated with cerebrovascular disease, whereas quantitative measures of white matter lesion and microstructure integrity were predicted by clearance and migration pathways. Functional connectivity alterations were related to genetic variants involved in signal transduction and synaptic communication.DISCUSSIONThis study reveals distinct genetic risk profiles in association with specific pathophysiological aspects in predementia stages of AD, unraveling the biological substrates of the heterogeneity of AD‐associated endophenotypes and promoting a step forward in disease understanding and development of personalized therapies.Highlights Polygenic risk for Alzheimer's disease encompasses six biological pathways that can be quantified with pathway‐specific genetic risk scores, and differentially relate to cerebrospinal fluid and imaging biomarkers. Inflammatory pathways are mostly related to cerebrovascular burden. White matter health is associated with pathways of clearance and membrane integrity, whereas functional connectivity measures are related to signal transduction and synaptic communication pathways.

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Chronic effects of inflammation on tauopathies

Cited by 26 publications

References 103 publications

Top 100 most-cited articles on tau protein: a bibliometric analysis and evidence mapping

Top 100 most-cited articles on tau protein: a bibliometric analysis and evidence mapping

Hotspots and trends of microglia in Alzheimer's disease: a bibliometric analysis during 2000–2022

Alzheimer's disease genetic pathways impact cerebrospinal fluid biomarkers and imaging endophenotypes in non‐demented individuals

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