Association ofMycoplasma genitaliumwith Nongonococcal Urethritis in Heterosexual Men

Abstract

Chlamydia trachomatis and Neisseria gonorrhoeae are universally acknowledged as urethral pathogens, yet the etiology in the majority of cases of urethritis is unclear. Our case-control study assessed the association of Mycoplasma genitalium, Ureaplasma urealyticum, and other potential pathogens with acute nongonococcal urethritis (NGU) in heterosexual men presenting to an urban sexually transmitted diseases clinic. M. genitalium was detected in 27 (22%) of 121 NGU case patients and in 5 (4%) of 117 control subjects (P<.01). Although C. trachomatis was detected in 36 (30%) of 121 NGU case patients and in 4 (3%) of 117 control subjects (P<.01), only 3 men with NGU were infected with both C. trachomatis and M. genitalium. U. urealyticum was not associated with NGU. By multivariate analyses, controlling for age, race, history of prior urethritis, and chlamydial infection, M. genitalium was associated with a 6.5-fold increased risk of urethritis (95% confidence interval, 2.1-19.5), which supports a role of this organism in the etiology of NGU.

Mycoplasma genitalium among Adolescent Women and their Partners

“…M. genitalium is associated with NGU, mucopurulent cervicitis, and other reproductive tract infections [8][9][10][11].…”

Mycoplasma genitalium: prevalence and behavioural risk factors in the general population

“…1 Individuals attending sexually transmitted disease (STD) clinics have been the group most thoroughly studied and those with urethritis/cervicitis have been compared with asymptomatic STD clinic attendees. Men with urethritis had M genitalium prevalences of 9.4-29.2%, [2][3][4][5][6][7] whereas asymptomatic men in the same high-risk populations had prevalences of 0.8-8.5%. [2][3][4][5][6][7] The corresponding figures for women with cervicitis in two major studies were 10-11% 2 8 and for women without cervicitis it was 3-5%.…”

“…Men with urethritis had M genitalium prevalences of 9.4-29.2%, [2][3][4][5][6][7] whereas asymptomatic men in the same high-risk populations had prevalences of 0.8-8.5%. [2][3][4][5][6][7] The corresponding figures for women with cervicitis in two major studies were 10-11% 2 8 and for women without cervicitis it was 3-5%. The concordance rate between partners is high, ranging from 45% to 58% of female partners to male index patients 2 9 whereas 38% and 56% of male partners to female index patients have been shown to be infected.…”

Aplicación de método molecular en la detección de Mycoplasma genitalium en hombres y en mujeres embarazadas

“…El 15 a 25% de los casos agudos de UNG serían causados por M. genitalium y un porcentaje no bien determinado por Ureaplasma sp [5][6][7][8][9]21 .…”

“…Por este motivo su diagnóstico se basa en técnicas moleculares, como la hibridación con sondas y la amplificación del ADN mediante reacción de polimerasa en cadena (RPC) [3][4][5] . Varios estudios efectuados mediante RPC han detectado M. genitalium en 15 a 25% de hombres con UNG [5][6][7][8][9] . En la mujer, M. genitalium ha sido asociado con cervicitis 5,[10][11] , enfermedad inflama-muestras clínicas fueron obtenidas con tórula fina de algodón e inmediatamente inoculadas en medio de transporte Stuart y en 1,5 ml de buffer de transporte sacarosa fosfato (buffer 2SP).…”