Association of IL‐17A‐197G/A and IL‐17F‐7488T/C polymorphisms and osteoarthritis susceptibility: A meta‐analysis

Abstract

Aim This meta‐analysis was conducted with the aim of collecting and synthesizing the existing evidence on the association of interleukin‐17A (IL‐17A)‐197G/A and IL‐17F‐7488T/C gene polymorphisms and osteoarthritis (OA) susceptibility. Methods Six electronic databases including PubMed, EMBASE, Web of Science, Cochrane Library, CNKI, and Wanfang were systematically searched for potentially relevant studies previous to June 2019. The strengths of association were estimated by summary odds ratios (ORs) and 95% confidence intervals (95%CIs) in a model‐free approach. Heterogeneity test and sensitivity analysis were also conducted to guarantee the reliability of this study. Results Six eligible case‐control studies comprising 1989 OA patients and 2116 healthy controls were obtained for the meta‐analysis. Dominant model was confirmed to be the optimal genetic model (MM + Mm vs mm). The pooled estimate supported that IL‐17A‐197G/A and IL‐17F‐7488T/C polymorphisms were significantly associated with OA susceptibility in the overall population (IL‐17A‐197G/A: GG + GA vs AA, OR = 0.69, 95%CI 0.57‐0.80; P < .001; IL‐17F‐7488T/C, TT + TC vs CC, OR = 0.46, 95%CI 0.29‐0.71, P < .001). However, subgroup analyses suggested the association only existed in Asians and knee OA. Conclusion The findings of the present study indicate that IL‐17A‐197G/A and IL‐17F‐7488T/C polymorphisms are positively associated to reduced risk of knee OA, especially in Asian populations.

IL‐17A‐197G/A and IL‐17F‐7488T/C polymorphisms and osteoarthritis susceptibility

“…The effect on clinical phenotypic manifestation is due to the molecular change resulting from the single polymorphism . In the present study, Gao et al could demonstrate the effects of both IL‐17A‐197G/A and IL‐17F‐7488T/C polymorphisms. This result can confirm that there are many possible underlying genetic factors that can affect the final phenotypic expression, OA susceptibility.…”

“…We read the publication “Association of IL‐17A‐197G/A and IL‐17F‐7488T/C polymorphisms and osteoarthritis (OA) susceptibility: A meta‐analysis” with great interest. Gao et al concluded that “IL‐17A‐197G/A and IL‐17F‐7488T/C polymorphisms are positively associated to reduced risk of knee OA, especially in Asian populations”. We would like to share ideas on the present report.…”

The role of IL17 and IL17RA polymorphisms in lethal pandemic acute viral pneumonia (Influenza A virus H1N1 subtype)

“…The different SNPs in the IL17 gene have been recently explored, aiming to gain knowledge about their association with the risk of disease (Kawaguchi et al 2006 ; Arisawa et al 2008 ; Rasouli et al 2013 ; Saraiva et al, 2013 ; Gao et al 2020 ; Xie et al 2019 ; Yang et al 2020 ). These aspects could help understand these patients' propensity for unfavorable outcomes (Yuan et al, 2010 ; Xie et al 2012 ).…”

Is interleukin-17 implicated in early knee osteoarthritis pathogenesis as in rheumatoid arthritis?

“…Several proofs suggest that IL-17A has a role in OA pathophysiology and IL-17-treated chondrocytes from OA patients showed enhanced expression of catabolic factors that are involved in the destruction of cartilage in OA [46]. Furthermore, IL-17F gene rs763780 C allele confers an increased risk of inflammatory arthritis in Caucasians [47][48][49].…”