Association of<i>Helicobacter pylori</i>infection with chronic obstructive pulmonary disease and chronic bronchitis: a meta-analysis of 16 studies

Wang, Feng; Liu, Juan; Zhang, Yun; Lei, Ping

doi:10.3109/00365548.2014.989539

Cited by 31 publications

(25 citation statements)

References 34 publications

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“…A prominent example of such pH-NO and host-microbe dynamics is the well-studied human pathogen Helicobacter pylori . Epidemiologically, H. pylori is linked to peptic ulcer disease, gastric cancer, as well as diabetes, autoimmune disease, chronic inflammation, CVD and endothelial dysfunction[240–245]. To survive the hostile gastric milieu, H. pylori has developed robust mechanisms for altering its local environment on two fronts.…”

Section: The Oral Microbiome and Bacterial Nitrate Reductionmentioning

confidence: 99%

Enterosalivary nitrate metabolism and the microbiome: Intersection of microbial metabolism, nitric oxide and diet in cardiac and pulmonary vascular health

Koch

Gladwin

Freeman

et al. 2017

Free Radical Biology and Medicine

143

127

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Recent insights into the bioactivation and signaling actions of inorganic, dietary nitrate and nitrite now suggest a critical role for the microbiome in the development of cardiac and pulmonary vascular diseases. Once thought to be the inert, end-products of endothelial-derived nitric oxide (NO) heme-oxidation, nitrate and nitrite are now considered major sources of exogenous NO that exhibit enhanced vasoactive signaling activity under conditions of hypoxia and stress. The bioavailability of nitrate and nitrite depend on the enzymatic reduction of nitrate to nitrite by a unique set of bacterial nitrate reductase enzymes possessed by specific bacterial populations in the mammalian mouth and gut. The pathogenesis of pulmonary hypertension (PH), obesity, hypertension and CVD are linked to defects in NO signaling, suggesting a role for commensal oral bacteria to shape the development of PH through the formation of nitrite, NO and other bioactive nitrogen oxides. Oral supplementation with inorganic nitrate or nitrate-containing foods exert pleiotropic, beneficial vascular effects in the setting of inflammation, endothelial dysfunction, ischemia-reperfusion injury and in pre-clinical models of PH, while traditional high-nitrate dietary patterns are associated with beneficial outcomes in hypertension, obesity and CVD. These observations highlight the potential of the microbiome in the development of novel nitrate- and nitrite-based therapeutics for PH, CVD and their risk factors.

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Section: The Oral Microbiome and Bacterial Nitrate Reductionmentioning

confidence: 99%

Enterosalivary nitrate metabolism and the microbiome: Intersection of microbial metabolism, nitric oxide and diet in cardiac and pulmonary vascular health

Koch

Gladwin

Freeman

et al. 2017

Free Radical Biology and Medicine

143

127

View full text Add to dashboard Cite

show abstract

“…Intriguing is the role of Helicobacter pylori. While this pathogen has long been linked with decreased incidence of asthma and allergy, s2 meta-analyses suggested that infection with H. pylori is positively associated with an increased incidence of COPD and other chronic bronchial diseases 70 , and that systemic immune responses triggered by H. pylori have different roles in the aetiology of different lung disorders 1 . Longitudinal and intervention studies will be needed to unravel whether these changes in gut and respiratory microbiota are a cause or consequence of COPD.…”

Section: Chronic Obstructive Pulmonary Diseasementioning

confidence: 99%

The Lung-Gut-Cross Talk in Chronic Airways Diseases

Wouters¹

2021

BRN

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The gut and lung microbiota are essential to health and vital for the development of the immune system and homeostasis. The vital cross-talk between mucosal tissues of our body in chronic respiratory conditions as asthma, chronic obstructive pulmonary disease and cystic fibrosis in stable conditions as well as during exacerbations is still poorly studied and understood. The gut-lung interaction and the dysbiosis of microbiota and leaky guts in the aetiology of these chronic respiratory diseases are reviewed.

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“…There is data that presence of Hp in the organism also elevates the risk for other comorbidities such as obstructive pulmonary disease, idiopathic pulmonary fibrosis, gestational diabetes, etc. [4][5][6].…”

Section: Metabolic Changes In Hp With T2dmmentioning

confidence: 99%

Helicobacter pylori and type 2 diabetes mellitus: searching for the links

Covanţev¹,

Ţîmbalari²,

Natalia³

2016

Russ. Open Med. J.

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The incidence and prevalence of type 2 diabetes mellitus is considered to be one of the most critical problems in the healthcare system. The pathophysiology of the disease has proven to be complicated and multiple factors are involved in its development. Recently Helicobacter pylori was proposed as a new risk factor for developing type 2 diabetes mellitus as well as other disease. This study is a review of the current data involving Helicobacter pylori association with type 2 diabetes mellitus and its complications.

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Association ofHelicobacter pyloriinfection with chronic obstructive pulmonary disease and chronic bronchitis: a meta-analysis of 16 studies

Abstract: Our meta-analysis suggested a potential relationship between H. pylori infection and the development of COPD and CB.

Cited by 31 publications

References 34 publications

Enterosalivary nitrate metabolism and the microbiome: Intersection of microbial metabolism, nitric oxide and diet in cardiac and pulmonary vascular health

Enterosalivary nitrate metabolism and the microbiome: Intersection of microbial metabolism, nitric oxide and diet in cardiac and pulmonary vascular health

The Lung-Gut-Cross Talk in Chronic Airways Diseases

Helicobacter pylori and type 2 diabetes mellitus: searching for the links

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