Association of FOXF2 gene polymorphisms with ischemic stroke in Chinese Han population

Abstract

Recently, a novel locus at chromosome 6p25 (rs12204590, near FOXF2) associated with an increased risk of stroke in European populations was identified. However, whether polymorphisms in FOXF2 are also associated with the incidence of ischemic stroke in other populations remains unknown. In this case-control study, 803 Chinese Han patients with ischemic stroke and 803 matched control individuals were enrolled. Four tag SNPs and rs12204590 located in or near FOXF2 were selected, and the associations between genotypes/alleles and ischemic stroke were analyzed. In our study, we did not detect an association between the previously reported locus rs12204590 and ischemic stroke. By the genotype analysis, a novel SNP rs1711972, near FOXF2, was observed to be associated with an increased risk of ischemic stroke(CA genotype, adjusted OR = 1.35; 95% CI, 1.07 to 1.70), but not significantly after Bonferroni corrections for multiple tests. However, in the subgroup analysis, we discovered that rs1711972 was associated with an increased risk of large-artery atherosclerotic stroke in the additive model (P = 0.020; CA genotype, adjusted OR = 1.50; 95%CI, 1.09 to 2.07) and dominant model (P = 0.010; OR = 1.47; 95%CI, 1.09 to 1.99). Collectively, these results indicate that a novel SNP near FOXF2 may influence the risk of large-artery atherosclerotic stroke in Chinese Han population.

The regulatory roles and mechanisms of the transcription factor FOXF2 in human diseases

“…TSPAN2, MMP12, CDC5L, and HDAC9 have been shown to be associated with LAA ischemic stroke, while ALDH2, FOXF2, and PRKCH are associated with SAO ischemic stroke ( Chauhan & Debette, 2016 ). Specifically, FOXF2 variant rs12204590 increases SAO ischemic stroke susceptibility in European populations ( Chauhan & Debette, 2016 ) and rs1711972 increases LAA ischemic stroke susceptibility in Han Chinese ( Shi et al, 2017 ). Furthermore, FOXF2 deletion causes demyelinating diseases of cerebral white matter and nervous lesion ( Kapoor et al, 2011 ).…”