Association of Hyperuricemia with Coronary Artery Disease in Gulab Devi Chest Hospital

Abstract

Background: Coronary artery disease is the most common and life threatening cardiac emergency presenting to a hospital. Having significant mortality and morbidity are on the rise in Pakistan. The objective of the study is to examine the association of elevated level of serum uric acid with ischemic heart disease among adult population, to guide planning for primary and secondary prevention of this disease in community.Subjects and Methods: This cross-sectional study studied 110 consecutive patients from 20-80 years of age presenting with IHD (Myocardial infarction, unstable angina). All the subjects who were approached to participate in the study, gave their consent. Face-to-face interviews were conducted using a structured questionnaire followed by laboratory tests.Results: Association of serum uric acid were lined up as gender, smoking, hypertension, diabetes mellitus, menopause, dyslipidemia, family history and obesity. In this study, out of 110 patients 35 (32%) were females and 74 (68%) were males. Minimum Age of patients in this study was 30 years and maximum age was 70 years This study revealed that chest pain was the most occurring symptom which was observed in 39 patients which are 35.45% of the total patients and the second most occurring symptom was Dyspnea which was observed in 32 patients which 29.09% of the total patients. The study reveals that the major risk factor observed in CAD patients is ‘HTN’ which was found in 81 patients which are 73.64% of the total patients. However, ‘Smoking’ and ‘DM’ are proximate in occurrence and were found in 59 (53.64%) and 56 (50.91%) patients respectively. The study revealed that hyperuricemia was more in males that was 34(22.67) than in females.Conclusion: This study concluded that there was no significant association between hyperuricemia with ischemic heart disease.

Modifiable risk factors of vasospastic angina: a systematic literature review

“…Not only has the functional aetiology been less studied, but the risk factor and triggers for it vary considerably from atherosclerotic or obstructive cardiac disease sometimes, to the extent that it resembles the profile of non-cardiac patients. 11,12 Traditionally vasospastic angina was considered relatively benign with a good prognosis but it is increasingly becoming clear that it might not be the case. 13 Vasospastic angina can result in a myriad of adverse cardiac events in the absence of flow limiting structural coronary artery lesions.…”