Association of hypersensitivity to the nematode Anisakis simplex with HLA class II DRB1∗1502-DQB1∗0601 haplotype

Anisakis simplex: from Obscure Infectious Worm to Inducer of Immune Hypersensitivity

“…Recent works have shown a genetic predisposition to A. simplex allergy (HLA class II alleles) studying 46 Caucasian (from Cantabria, northern Spain) patients allergic to A. simplex. The DRB1*1502-DQB1*0601 haplotype was significantly associated with allergy to A. simplex (239). These authors, based on published works by others, discuss the frequency of this haplotype in different populations, which is common in the Asian population and is relatively frequent among Scottish Highlanders, Spanish Gypsies, Romanians, and Italians but absent or very rare in the populations of Norway, Germany, Denmark, Hungary, France, and Spain.…”

“…The so-called "Thai" allele (DRB1*1502) is frequent in Japan, Korea, Thailand, and Vietnam and in Canadians of Indian ancestry and relatively uncommon in Basques and Cantabrians (from the north of Spain). The "Welsh" allele (DQB1*0601) is frequent among the Welsh, the Wailibri people (Australia), and Asians (214,239). Furthermore, HLA DRB1*1502, DQB1*0601, and DRB I *0404 are significantly overrepresented (and hence probable genetic risk factors) in subjects allergic to A. simplex (239).…”

“…The "Welsh" allele (DQB1*0601) is frequent among the Welsh, the Wailibri people (Australia), and Asians (214,239). Furthermore, HLA DRB1*1502, DQB1*0601, and DRB I *0404 are significantly overrepresented (and hence probable genetic risk factors) in subjects allergic to A. simplex (239). The newly characterized allergens Ani s 2 and Ani s 3 ( (190,192) are showing that allergy in Europe is not confined to the Basque Country but is also in Japan, where more cases have also been diagnosed (152).…”

Sensitivity to Bee Venom Antigen Phospholipase A2: Association With Specific HLA Class I and Class II Alleles and Haplotypes in Beekeepers and Allergic Patients

“…Genomic DNA was extracted from peripheral EDTAblood lymphocytes as previously described [9,10]. HLA-DRB1, HLA-DQA1, and HLA-DQB1 alleles were detected by PCR-SSO-reverse dot blot, by PCR amplification with sequence-specific primers (PCR-SSP), and by PCR-RFLP, respectively, as described [10,11].…”

Opinion of the Scientific Panel on Dietetic products, nutrition and allergies [NDA] on a request from the Commission relating to the evaluation of allergenic foods for labelling purposes

“…Sénéchal et al (1999) described involvement of HLA-DR7 in the allergic response to apple and pollen, but concluded that the increased susceptibility conferred by HLA-DR7 was more related to atopy than to allergen-specific responses. Hypersensitivity to the fish parasite Anisakis simplex has been found to be associated with the HLA-DRB1*1502-DQB1*0601 haplotype (Sánchez-Velasco et al, 2000). Some HLA-types show distinct geographical variation.…”