Association of Human Papillomavirus Type 58 Variant With the Risk of Cervical Cancer

Abstract

Human papillomavirus (HPV) type 58 has been found to be prevalent among Chinese patients with cervical cancer. This study examined the oncogenic risk of HPV58 variants in Hong Kong, a southern part of China. Altogether, 1924 women were studied: 42.8% with a normal cervix, 16.2% with cervical intraepithelial neoplasia (CIN) I, 12.7% with CIN II, 20.8% with CIN III, and 7.6% with invasive cervical cancer (ICC). The overall prevalence of HPV58 was 11.4% (220) and increased statistically significantly with the severity of neoplasia (P(trend)<.001, chi(2) test for trend). Among HPV58-positive women, the occurrence of E7 632C-->T (T20I) and E7 760G-->A (G63S) variants (T20I/G63S) showed a positive trend of association with the severity of neoplasia (P(trend)<.001, chi(2) test for trend). HPV58 variants carrying these two substitutions showed an odds ratio (OR) for ICC of 26.79 (95% confidence interval = 10.14 to 74.72), and this OR was 6.9-fold higher than the ORs of variants without these substitutions. Patients with CIN III or ICC who were also infected with T20I/G63S variants had a statistically significant younger age at diagnosis than those infected with other variants (median age = 37 years versus 48 years; P =.038, two-sided Mann-Whitney U test). Thus, HPV58 variants carrying E7 T20I/G63S substitutions may be associated with an increased risk for cervical cancer.

High-risk Human Papillomavirus Genotype Detection by Electrochemical DNA Chip Method

“…A previous study of HPV 58 described its evolution and spread. The original source of ancient HPV58 may have been in West Africa and Southeast Asia may be a subsequent "relay center" (Chan et al, 2002;Li et al, 2009). These results have shown the diversity of HPV genotypes which provide information with regard to the design of multivalent prophylactic vaccines suitable for each geographical area.…”

Distribution of human papillomavirus types in cervical cancers in Hong Kong: Current situation and changes over the last decades

“…The DNA quality of paraffin-embedded tissues was assessed by a PCR targeting a 355-bp fragment of the house-keeping gene beta-globin. 19 The presence of HPV DNA was detected by the INNO-LiPa HPV Genotyping Extra kit (Innogenetics, Belgium), which can identify 27 HPV types (HPV6, 11,16,18,26,31,33,35,39,40,43,44,45, 51, 52, 53, 54, 56, 58, 59, 66, 68, 69, 70, 71, 73 and 82). The INNO-LiPa kit was selected for paraffin-embedded tissues because it targets a shorter fragment (65 bp) that can usually be recovered from formalin-fixed tissues.…”

“…[1][2][3][4] There are more than 40 HPV types that can infect the female genital tract. These genital HPVs are classified into high risk (HPV16,18,31,33,35, 39, 45, 51, 52, 56, 58, 59, 68, 73 and 82), probable high risk (HPV26, 53, 66, 67, 69 and IS39), and low and unknown risk (HPV6,11, 40, 42, 43, 44, 54, 61, 62, 70, 71, 72, 81 and CP6108) on the basis of their epidemiological risk for cervical cancer development. [5][6][7][8] The high-risk types show a biased distribution among cancer specimens collected worldwide due to their difference in oncogenicity, and perhaps as well as their intrinsic geographical predilection.…”

Comparison of HPV type distribution in high-grade cervical lesions and cervical cancer: a meta-analysis

“…(2003) HPV52 (0.39, 0.26, 0.64) or HPV58 (0.55, 0.24, 0.30). However, notably high ratios were observed for HPV31 in South/Central America (1.13, 95% CI 0.84 -1.70) in comparison to Europe (0.41, 95% CI 0.36 -0.48) and Asia (0.43, 95% CI 0.31 -0.68), and for HPV58 in China (including Taiwan and Hong Kong) (1.27, 95% CI 0.85 -2.51) in comparison to non-Chinese Asian countries (0.37, 95% CI 0.27 -0.58), raising the possibility of localised variation in the malignant potential of particular HPV types (Chan et al, 2002).89, 101 -105 & 2003 Cancer Research UK All rights reserved 0007 -0920/03 $25.00 www.bjcancer.com Molecular and Cellular PathologyOur findings suggest that worldwide, HSIL infected with HPV16, 18 or 45 are more likely to progress to SCC than HSIL infected with other HR types. This could be interpreted in two ways: either these types have a greater potential to induce fully malignant transformation, and/or these infections somehow preferentially evade the host immune system.…”

“…When estimated from studies within Asia, Europe and South/Central America, respectively, there was no material difference in SCC : HSIL ratios for HPV16 (1.46, 1.17, 1.40), HPV18 (1.74, 2.02, 1.46), HPV45 (4.35,1.39,1.20),HPV33 (0.56,0.62,0.76),HPV52 (0.39,0.26,0.64) or HPV58 (0.55,0.24,0.30). However, notably high ratios were observed for HPV31 in South/Central America (1.13, 95% CI 0.84 -1.70) in comparison to Europe (0.41, 95% CI 0.36 -0.48) and Asia (0.43, 95% CI 0.31 -0.68), and for HPV58 in China (including Taiwan and Hong Kong) (1.27, 95% CI 0.85 -2.51) in comparison to non-Chinese Asian countries (0.37, 95% CI 0.27 -0.58), raising the possibility of localised variation in the malignant potential of particular HPV types (Chan et al, 2002).…”