Association of HLA-DRB1*0405 with resistance to multibacillary leprosy in Taiwanese

Hsieh, Nan-Kuang; Chu, Chen‐Chung; Lee, Nie-Sue; Lee, Hui-Lin; Lin, Marie C.

doi:10.1016/j.humimm.2010.03.007

Cited by 14 publications

(8 citation statements)

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“…General clinical characteristics, HLA typing, and causes of ESRD were obtained from the health records of the organ donation and transplantation office of the hospital. The control group included 190 unrelated healthy Taiwanese individuals from a previous study that we conducted at the Mackay Memorial Hospital in Taipei to investigate the association between HLA polymorphism and multibacillary leprosy [ 17 ]. All patient and control individuals were Taiwanese, descendant of early Minnan or Hakka Chinese from the Fukien and Kwangton provinces on the south-east-coast of China who settle in Taiwan in the last 400 years.…”

Section: Methodsmentioning

confidence: 99%

Association between human leucocyte antigen subtypes and risk of end stage renal disease in Taiwanese: a retrospective study

et al. 2015

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BackgroundEnd stage renal disease (ESRD) is prevalent in Taiwan. Human leukocyte antigens (HLA) have been found to be associated with the pathogenesis of autoimmune diseases, allergies and inflammatory bowel diseases, and there are emerging evidences of correlations between HLA genotypes and renal diseases such as diabetic nephropathy, IgA nephropathy, and glomerulonephritis. The aim of this study is to investigate detailed HLA subtypes in a case-control study of Taiwanese individuals.MethodsThe polymorphisms of HLA class I and II antigens in ESRD patients and a healthy control group were retrospectively analyzed. The information of 141 ESRD patients was obtained from the medical record of the Keelung branch of Chang Gung Memorial Hospital and was compared to the HLA type of a control group comprized of 190 healthy unrelated Taiwanese from one of our previous studies. In order to standardize the HLA designation of prior low-resolution typings with the more advanced DNA based typings, all HLA-A, −B and -DR were analyzed using a low resolution serologic equivalent.ResultsThe current work suggests that HLA-DR3 (odds ratio = 1.91, 95 % CI = 1.098–3.324, P = 0.024, Pc = 0.312) and HLA-DR11 (odds ratio = 2.06, 95 % CI = 1.133–3.761, P = 0.021, Pc = 0.273) may represent susceptibility risk factors for the development of ESRD in Taiwanese individuals. On the other hand, HLA-DR8 (odds ratio = 0.47, 95 % CI = 0.236–0.920, p = 0.027. Pc = 0.351) may be a protective factor. HLA-A and -B antigens did not show any contribution of progression to ESRD. However, we note that the significance of all these findings is lost when the results are corrected for multiple comparisons according to Bonferroni. Further investigation with a larger group of patients and control is needed to resolve this issue.ConclusionsHLA typing might be a useful clinical method for screening patients with high risk of progression to ESRD.

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Section: Methodsmentioning

confidence: 99%

Association between human leucocyte antigen subtypes and risk of end stage renal disease in Taiwanese: a retrospective study

et al. 2015

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“…This allele is a susceptibility marker for leprosy per se, confirming the results of a previous study that showed an association between HLA-DR2 and leprosy in patients from an equivalent geographic region (Visentainer et al 1997). An association of HLA-DRB1*16 with susceptibility to leprosy per se has been described in many populations around the world, such as in Suriname, Brazil, Venezuela, Egypt, China, Japan, Korea, Taiwan, Mexico and Turkey (Hegazy et al 2002, Joko et al 2000, Gorodezky et al 2004, Hsieh et al 2010.…”

Section: Discussionmentioning

confidence: 98%

Association analysis of human leukocyte antigen class II (DRB1) alleles with leprosy in individuals from São Luís, state of Maranhão, Brazil

Corrêa

Aquino

Caldas

et al. 2012

Mem. Inst. Oswaldo Cruz

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Epidemiological studies have demonstrated that the variability of the clinical response to infection caused by Mycobacterium leprae is associated with host genetic factors. The present study investigated the frequency of human leukocyte antigen (HLA) class II (DRB1) alleles in patients with leprosy from São Luís, Maranhão, Brazil. A case-control study was performed in 85 individuals with leprosy and 85 healthy subjects. All samples were analysed via polymerase chain reaction-sequence specific oligonucleotide probes. The HLA-DRB1*16 allele showed a higher frequency in the group with leprosy [(9.41% vs. 4.12%) odds ratio (OR) = 2.41 95% confidence interval (CI) (0.96-6.08) p = 0.05], whereas the HLA-DRB1*11 allele was less frequent in the group with leprosy [(6.47% vs. 11.76%) OR = 0.51 95% CI (0.23-1.12) p = 0.09]. The frequency of HLA-DRB1* alleles between the control group and leprosy patient subgroups presenting different forms of the disease showed that the HLA-DRB1*16 (16.13% vs. 8.24%, OR = 4.10, CI = 1.27-13.27, p = 0.010) and HLA-DRB1*14 (5% vs. 3.53%, OR = 4.63, CI = 1.00-21.08, p = 0.032) alleles were significantly more frequent in patients with different clinical subtypes of leprosy. The sample size was a limitation in this study. Nevertheless, the results demonstrated the existence of a genetic susceptibility associated with the clinical forms of leprosy. The low frequency of the HLA-DRB1*11 allele should be further studied to investigate the possible protective effect of this allele.

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“…Alternatively, peptide presentation by specific class II molecules may result in activation of suppressor/regulatory T-cells [37]. A protective effect against leprosy has been described for DRB1*04 in Brazilian, Korean, Japanese, Vietnamese, Argentinean, and Taiwanese populations [30,[38][39][40].…”

Section: Hla and Leprosymentioning

confidence: 99%

HLA and Infectious Diseases

Cardozo¹,

Marangon²,

Sell³

et al. 2014

HLA and Associated Important Diseases

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HLA and Associated Important Diseases 260CD . During antigen presentation, CD and CD are intimately associated with the TCR and bind to the MHC molecule [ ].. Haplotype, linkage disequilibrium and HLA genes expression HL" genes are transmitted for Mendel segregation and allelic variant is expressed in a codominant mode. The set of HL" alleles present in each chromosome of the pair is denominated haplotype. The probability of a sibling having the same HL" haplotype as the other is %, different haplotypes is % and % are share only one haplotype [ ].Moreover, there is a fact that occurs in HL" genes called linkage disequilibrium which denotes that certain alleles occur together with a greater frequency than would be expected by chance non-random gametic association . Variations in the expected combinations of alleles in the population, more often or less often than would be expected from a random formation of haplotypes from alleles, could be related to linkage disequilibrium [ ]. For example, a determined population has a gene frequency of % for HLA-A* and % for HLA-B* , therefore the expected frequency for this haplotype would be . % . x . , the actual frequency is however, . % in this population, a higher frequency than expected, characterizing a positive linkage disequilibrium [ ].. HLA and infection diseasesThe frequency and the presence of HL" alleles vary among different populations. Studies suggest that the alleles that can confer resistance to certain pathogens are prevalent in areas with endemic diseases. Furthermore, genomic analysis in families has helped to map and identify the loci related to a number of diseases. Moreover, a number of diseases have been mapped and had their related loci identified thanks to the genomic analysis of families.

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Association of HLA-DRB1*0405 with resistance to multibacillary leprosy in Taiwanese

Cited by 14 publications

References 30 publications

Association between human leucocyte antigen subtypes and risk of end stage renal disease in Taiwanese: a retrospective study

Association between human leucocyte antigen subtypes and risk of end stage renal disease in Taiwanese: a retrospective study

Association analysis of human leukocyte antigen class II (DRB1) alleles with leprosy in individuals from São Luís, state of Maranhão, Brazil

HLA and Infectious Diseases

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