Association between human leucocyte antigen subtypes and risk of end stage renal disease in Taiwanese: a retrospective study

Dai, Ciou-Sia; Chu, Chen‐Chung; Chen, Shin-Fan; Sun, Chiao‐Yin; Lin, Min; Lee, Chin‐Chan

doi:10.1186/s12882-015-0165-7

Cited by 20 publications

(20 citation statements)

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“…Several reports have examined possible associations between HLA types and ESRD 182,183,184 . Most of these studies have studied waitlisted candidates for renal transplantation in fairly homogeneous ethnic populations.…”

Section: Hla and Disease-independent Risk Of Esrdmentioning

confidence: 99%

HLA and kidney disease: from associations to mechanisms

et al. 2018

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Since the first association between HLA and diseases of native kidneys was described almost 50 years ago, technological and conceptual advances in HLA biology and typing, together with better case ascertainment, have led to an improved understanding of HLA associations with a variety of renal diseases. A substantial body of evidence now supports the existence of HLA genetic associations in the field of renal disease beyond the role of HLA in allogeneic responses in transplant recipients. Allomorphs of HLA have emerged as important risk factors in most immune-mediated renal diseases, which, together with other genetic and environmental factors, lead to loss of tolerance and autoimmune-mediated renal inflammation. HLA associations have also been described for renal diseases that are less traditionally seen as autoimmune or immune-mediated. Here, we review essential concepts in HLA biology and the association of HLA with diseases of the native kidneys, and describe the current understanding of the epistatic and mechanistic bases of HLA-associated kidney disease. Greater understanding of the relationship between HLA and kidney function has the potential not only to further the understanding of immune renal disease at a fundamental level but also to lead to the development and application of more effective, specific and less toxic therapies for kidney diseases.

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Section: Hla and Disease-independent Risk Of Esrdmentioning

confidence: 99%

HLA and kidney disease: from associations to mechanisms

et al. 2018

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“…[7,8] Several emerging studies have described significant correlations between HLA and some renal diseases such as diabetic nephropathy, IgA nephropathy, and glomerulonephritis. [9,10] However, specific HLA types associated with ESRD have not been well documented. In this study, we aimed to show GHLA distribution in our region and the frequency of HLA allels in patients with chronic renal disease.…”

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confidence: 99%

Association Between Human Leukocyte Antigen ( HLA ) With Chronic Renal Disease

Kodaz¹

2017

EJMI

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“…HLA-DRB1*03 has been found to be protective against IgA nephropathy in European people 19 ; this study found that DRB1*03:01 was linked to increased renal function in Black African subjects. On the other hand, the same gene has been reported to be linked to increased risk of kidney dysfunction in Taiwanese, 20 Saudi Arabian, 21 Turkish, 13 and Brazilian 22 subjects. This study also found that HLA-DRB1*03:01 is linked to decreased kidney function in Indian subjects.…”

Section: Discussionmentioning

confidence: 98%

Human leukocyte antigen associations with renal function among ethnic minorities in the United Kingdom

Lowe

Payton

Verma

et al. 2020

HLA

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Human leukocyte antigens (HLA) have been associated with renal function, but previous studies report contradictory findings. There has been a lack of research into how HLA affects renal function in Black, Asian and Minority Ethnic (BAME) people in the UK, despite BAME people being disproportionately affected by renal dysfunction. This study included >27 000 UK Biobank subjects of six ethnicities (>12 100 Irish, >5400 Indian, >4000 Black Caribbean, >3000 Black African, >1600 Pakistani, and >1400 Chinese) aged 39 to 73. Subjects' high-resolution HLA genotypes were imputed using HLA*IMP:02 software. Regression analysis was used to compare 108 imputed HLA alleles with two measures of estimated glomerular filtration rate (eGFR): one based on serum creatinine; one based on serum cystatin. Secondary analysis compared CKD stage 2 subjects to healthy controls. Nine imputed HLA alleles were associated with eGFR (adjusted P < .05). Six associations were based on creatinine in Black African subjects: HLA-B*53:01 (beta = −2.628, adjusted P = 4.69 × 10 −4); C*04:01 (beta = −1.667, adjusted P = .0269); DPA1*02:01 (beta = −1.569, adjusted P = .0182); and DPA1*02:02 (beta = −1.716, adjusted P = .0251) were linked to decreased renal function, while DRB1*03:01 (beta = 3.200, adjusted P = 3.99 × 10 −3) and DPA1*01:03 (beta = 2.276, adjusted P = 2.31 × 10 −5) were linked to increased renal function. Two of these (HLA-B*53:01 and C*04:01) are commonly inherited together. In Irish subjects, HLA-DRB1*04:01 (beta = 1.075, adjusted P = .0138) was linked to increased eGFR (based on cystatin); in Indian subjects, HLA-DRB1*03:01 (beta = −1.72, adjusted P = 4.78 × 10 −3) and DQB1*02:01 (beta = −1.755, adjusted P = 2.26 × 10 −3)were associated with decreased eGFR (based on cystatin). No associations were found in the other three ethnic groups. Nine HLA alleles appear to be associated with kidney function in BAME people in the UK. This could have applications for the diagnosis and treatment of renal disease and could help reduce health inequalities in the UK.

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Association between human leucocyte antigen subtypes and risk of end stage renal disease in Taiwanese: a retrospective study

Cited by 20 publications

References 50 publications

HLA and kidney disease: from associations to mechanisms

HLA and kidney disease: from associations to mechanisms

Association Between Human Leukocyte Antigen ( HLA ) With Chronic Renal Disease

Human leukocyte antigen associations with renal function among ethnic minorities in the United Kingdom

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