Association of HLA class I and II genes with cutaneous leishmaniasis: a case control study from Sri Lanka and a systematic review

Samaranayake, Nilakshi; Fernando, Sumadhya Deepika; Neththikumara, Nilaksha; Rodrigo, Chaturaka; Karunaweera, Nadira D.; Dissanayake, Vajira H. W.

doi:10.1186/s12879-016-1626-8

Cited by 20 publications

(16 citation statements)

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“…Furthermore, in patients with positive HPV DNA at both anatomical sites, HPV strains were mostly different. The absence of concordance has also been observed in another few studies conducted in HIV-positive men [ 7 , 11 , 14 , 30 , 31 ]. It is possible that the considerably lower prevalence of HPV DNA at the oral cavity when compared to the anus, together with the lack of concordance in HPV type-specific infections, allows the hypothesis that HPV at the oral site is acquired independently of ano-genital infection or perhaps at different points in time.…”

Section: Discussionmentioning

confidence: 55%

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Oral human Papillomavirus DNA detection in HIV-positive men: prevalence, predictors, and co-occurrence at anal site

Vergori

Garbuglia

Piselli³

et al. 2018

BMC Infect Dis

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BackgroundHIV-positive patients carry an increased risk of HPV infection and associated cancers. Therefore, prevalence and patterns of HPV infection at different anatomical sites, as well as theoretical protection of nonavalent vaccine should be investigated. Aim was to describe prevalence and predictors of oral HPV detection in HIV-positive men, with attention to nonavalent vaccine-targeted HPV types. Further, co-occurrence of HPV DNA at oral cavity and at anal site was assessed.MethodsThis cross-sectional, clinic-based study included 305 HIV-positive males (85.9% MSM; median age 44.7 years; IQR: 37.4–51.0), consecutively observed within an anal cancer screening program, after written informed consent. Indication for anal screening was given by the HIV physician during routine clinic visit. Paired oral rinse and anal samples were processed for the all HPV genotypes with QIASYMPHONY and a PCR with MY09/MY11 primers for the L1 region.ResultsAt the oral cavity, HPV DNA was detected in 64 patients (20.9%), and in 28.1% of these cases multiple HPV infections were found. Prevalence of oral HPV was significantly lower than that observed at the anal site (p < 0.001), where HPV DNA was found in 199 cases (85.2%). Oral HPV tended to be more frequent in patients with detectable anal HPV than in those without (p = 0.08). Out of 265 HPV DNA-positive men regardless anatomic site, 59 cases (19.3%) had detectable HPV at both sites, and 51 of these showed completely different HPV types. At least one nonavalent vaccine-targeted HPV type was found in 17/64 (26.6%) of patients with oral and 199/260 (76.5%) with anal infection. At multivariable analysis, factors associated with positive oral HPV were: CD4 cells <200/μL (versus CD4 cells >200/μL, p = 0.005) and >5 sexual partners in the previous 12 months (versus 0–1 partner, p = 0.008).ConclusionsIn this study on Italian HIV-positive men (predominantly MSM), oral HPV DNA was detected in approximately one fifth of tested subjects, but prevalence was significantly lower than that observed at anal site. Low CD4 cell count and increasing number of recent sexual partners significantly increased the odds of positive oral HPV. The absence of co-occurrence at the two anatomical sites may suggest different routes or timing of infection.

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Section: Discussionmentioning

confidence: 55%

“…This finding differed from previous studies, that showed HPV16 as the predominant type [ 6 , 33 ], and may have epidemiological implications. In fact, HPV16 is found in more than 85% of HPV OSSC [ 6 ], and a case-control study estimated that oral HPV16 confers a 50-fold increase in the odds of HPV-driven oro-pharyngeal cancer [ 31 ].…”

Section: Discussionmentioning

confidence: 99%

Oral human Papillomavirus DNA detection in HIV-positive men: prevalence, predictors, and co-occurrence at anal site

Vergori

Garbuglia

Piselli³

et al. 2018

BMC Infect Dis

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“…Significantly elevated tissue expression of IFN-γ and tumour necrosis factor TNF-α was seen in lesions that presented later than 6 months from the time of infection [33]. Also, a case-control study conducted by Samaranayake et al [35] suggested particular human leukocyte antigen (HLA) genes may have a role in determining the predisposition to localized CL.…”

Section: Immunological and Genetic Significances Of CL In Sri Lankamentioning

confidence: 98%

“…This higher susceptibility than other ethnic groups may determine by genetic factors [36]. Further work is required to completely identify important genetic characteristics in humans that are associated with increased susceptibility to CL infection [35,37].…”

Section: Immunological and Genetic Significances Of CL In Sri Lankamentioning

confidence: 99%

A Comprehensive Review of Cutaneous Leishmaniasis in Sri Lanka and Identification of Existing Knowledge Gaps

Amarasinghe

Wickramasinghe

2020

Acta Parasit.

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Purpose Sri Lanka is endemic to cutaneous leishmaniasis and reported as the latest focus of leishmaniasis in the Asian subcontinent. Annually, the number of leishmaniasis cases is increasing; therefore, more efficient diagnostic tools, treatment methods and effective prevention measures are indispensable. For this reason, many studies were conducted regarding leishmaniasis infections in Sri Lanka; however, some areas need more attention. Thus, in this review, we comprehensively discussed the studies on leishmaniasis carried out in Sri Lanka. Methods Published articles on leishmaniasis in Sri Lanka were searched on PubMed, Google Scholar and ResearchGate databases. Inclusion criteria for the articles were based on keyword searches including 'Leishmaniasis in Sri Lanka', 'Leishmaniasis vector in Sri Lanka', 'Sandfly species in Sri Lanka', 'Leishmaniasis epidemiology in Sri Lanka' which are publicly accessible as of 15th July 2019. Results In this study, we evaluated and summarized the leishmaniasis reports in Sri Lanka and mainly focused on clinical presentation of leishmaniasis infection, genetic characteristics of Leishmania donovani Sri Lankan strain, geographical distribution and associated environmental factors, immunological aspects of the infection, vector, reservoir host, risk factors, diagnosis and treatment, and prevention and control. Furthermore, we identified the areas where further research is needed to fill the essential knowledge gaps. Conclusions Leishmaniasis has become a critically important parasitic infection in Sri Lanka, whereas the significant clinical form is cutaneous leishmaniasis. Prevalence of the leishmaniasis infections is reported from all the districts of the country. Therefore, more studies are essential to be carried out to fill the existing knowledge gaps emphasized in this review.

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“…It is known that parasite strain, genetically or environmentally determined host immune response, and vector components all contribute [ 3 , 34 , 35 , 36 ]. Further investigation is needed to define the contributions of host genetics and microbiota to the cutaneous manifestations of leishmaniasis [ 37 , 38 , 39 , 40 ].…”

Section: Introductionmentioning

confidence: 99%

Cutaneous Manifestations of Human and Murine Leishmaniasis

Scorza

Carvalho

Wilson

2017

IJMS

164

136

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The leishmaniases are diseases caused by pathogenic protozoan parasites of the genus Leishmania. Infections are initiated when a sand fly vector inoculates Leishmania parasites into the skin of a mammalian host. Leishmania causes a spectrum of inflammatory cutaneous disease manifestations. The type of cutaneous pathology is determined in part by the infecting Leishmania species, but also by a combination of inflammatory and anti-inflammatory host immune response factors resulting in different clinical outcomes. This review discusses the distinct cutaneous syndromes described in humans, and current knowledge of the inflammatory responses associated with divergent cutaneous pathologic responses to different Leishmania species. The contribution of key hematopoietic cells in experimental cutaneous leishmaniasis in mouse models are also reviewed and compared with those observed during human infection. We hypothesize that local skin events influence the ensuing adaptive immune response to Leishmania spp. infections, and that the balance between inflammatory and regulatory factors induced by infection are critical for determining cutaneous pathology and outcome of infection.

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Association of HLA class I and II genes with cutaneous leishmaniasis: a case control study from Sri Lanka and a systematic review

Cited by 20 publications

References 47 publications

Oral human Papillomavirus DNA detection in HIV-positive men: prevalence, predictors, and co-occurrence at anal site

Oral human Papillomavirus DNA detection in HIV-positive men: prevalence, predictors, and co-occurrence at anal site

A Comprehensive Review of Cutaneous Leishmaniasis in Sri Lanka and Identification of Existing Knowledge Gaps

Cutaneous Manifestations of Human and Murine Leishmaniasis

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