Association of High Vitamin D Status with Low Circulating Thyroid-Stimulating Hormone Independent of Thyroid Hormone Levels in Middle-Aged and Elderly Males

Zhang, Qingqing; Wang, Zhixiao; Sun, Min; Cao, Mengdie; Zhu, Zhenxin; Fu, Qi; Gao, Yuan; Jia, Mengmeng; Li, Yanyun; Shi, Yun; Yang, Fan; Zheng, Shuai; Tang, Wei; Duan, Yu; Huang, Xiaoping; He, Wei; Yang, Tao

doi:10.1155/2014/631819

Cited by 49 publications

(53 citation statements)

References 25 publications

(28 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Many studies showed role of vitamin D on thyroid hormone due to its activity in thyroid gland [2,11] and even in patients with thyroid diseases and thyroid autoantibody [46,47]. However, few studies focus on the link between 25-(OH)D and thyroid hormones during pregnancy.…”

Section: Discussionmentioning

confidence: 99%

Correlation of Serum 25-Hydroxyvitamin D and Thyroid Hormones in Pregnant Women in Amman-Jordan

Nizar¹

2017

JMEN

View full text Add to dashboard Cite

Aim: The aim of this study is to investigate changes of vitamin D and thyroid hormones levels during pregnancy to maintain normal fetus development and growth.Method: Serum hydroxyl vitamin 25(OH)D and thyroid levels were measured in109 pregnant women referred to our laboratory from prenatal clinic during the period of May to October 2015.Blood samples were detected for 25 (OH) vitamins D, TSH, FT4 and FT3 by chemiluminescent (Tosoh A1A, Japan).Results: Pregnant women aged 19-45years (18.2 years age average) were examined. The mean 25(OH) D was 21.7±5.6 ng/ml (range 8.7 to 47.2). The mean levels of Serum Free T3, FT4 and TSH were 1.61 ± 0.21, ng/dl, 0.86 ± 0.23 ng/ dl and 1.56 ± .9 μIU/ml respectively, results for 25(OH) D mean values were 29.5 ng/ml (27.9%), 33.2 ng/ml (49.6%) and 37.3 ng/ml (22.5%) for vitamin D deficiency, insufficiency and sufficiency respectively. No correlation was found between vitamin D, TSH, FT4 and FT3 however, there was statistical significant correlation between the vitamin D and TSH (p<0.05), level especially in patients with sufficient vitamin D level. Conclusion:Association between higher vitamin D (>30.0 ng/ml) and lower TSH in pregnant was observed (P<0.005). However, no correlation between 25-Hydroxyvitamin D FT4 and FT3 hormone was observed.

show abstract

Section: Discussionmentioning

confidence: 99%

Correlation of Serum 25-Hydroxyvitamin D and Thyroid Hormones in Pregnant Women in Amman-Jordan

Nizar¹

2017

JMEN

View full text Add to dashboard Cite

show abstract

Section: (Oh)d Values Than Healthy Controls (P =mentioning

confidence: 93%

“…Vitamin D levels were found associated with low circulating TSH levels in middle-aged and elderly males, independently of T3 and T4 levels. Interestingly, serum TSH levels in women were higher than those of same-aged men, indicating that TSH secretion may be regulated by sex hormones [5].Vitamin D status was also evaluated in female GD patients, showing significant lower levels compared with controls and demonstrating an association between serum 25(OH)D levels and serum calcium and intact parathyroid hormone levels. Recently, Yasuda and coworkers found an…”

mentioning

confidence: 99%

Vitamin D and thyroid autoimmune diseases: the known and the obscure

Bizzaro

Shoenfeld

2014

Immunol Res

View full text Add to dashboard Cite

Vitamin D is a secosteroid hormone, obtained from the diet or synthesized in human skin from 7-dehydrocholesterol after UV irradiation exposure. Its importance in calcium homeostasis is well recognized, as well its role in decreasing the risk of rickets, fractures, osteopenia, osteomalacia, and osteoporosis. What is a new developing issue is the involvement of vitamin D deficiency (commonly defined as less than 30 ng/ml) in the boost of many other disorders and especially in autoimmune diseases [1]. In light of these new acquisitions, vitamin D deficiency may represent a global health problem that has been underestimated for many years.Among all the autoimmune diseases which show an association with vitamin D deficiency and disease progression, we will focus on autoimmune thyroid diseases (AITD). Indeed, vitamin D deficiency modulates both Hashimoto thyroiditis (HT) and Graves' disease (GD). In several studies, the association between vitamin D and AITD was assessed analyzing various serological parameters, such as serum 25(OH)D levels, serum calcium, phosphate, parathyroid hormone (PTH), and antithyroid antibody levels. HT patients had significantly lower 25(OH)D values than healthy controls (p = 0.001), and low levels of serum 25(OH)D were also correlated with disease duration, thyroid volume, and antibody levels [2]. The association between vitamin D deficiency and antithyroid antibodies was reported for the first time by Kivity et al. [3], who studied a cohort of 92 patients with thyroid disorders, collected in a Hungarian endocrinology clinic. Antithyroid peroxidase (TPOAb) and antithyroglobulin (TgAb) antibodies were significantly more common in patients with vitamin D deficiency than in those with normal vitamin D levels. Hypovitaminosis D and thyroid autoimmunity were also described in a Chinese female population, where decreased TPOAb levels were associated with higher vitamin D levels. Interestingly, the correlation was found only in premenopausal women, but not in postmenopausal women or in men [4]. This result suggests a likely involvement of estrogens in modulating AITD. Moreover, the relationship between serum vitamin D status and thyroid-stimulating hormone (TSH) levels was investigated. Vitamin D levels were found associated with low circulating TSH levels in middle-aged and elderly males, independently of T3 and T4 levels. Interestingly, serum TSH levels in women were higher than those of same-aged men, indicating that TSH secretion may be regulated by sex hormones [5].Vitamin D status was also evaluated in female GD patients, showing significant lower levels compared with controls and demonstrating an association between serum 25(OH)D levels and serum calcium and intact parathyroid hormone levels. Recently, Yasuda and coworkers found an

show abstract

“…In a study done by Kivity et al (13) they showed that 79% of HT patients have 25(OH)D< 10ng/mL. A study by Zhang et al (14) has reported that a higher circulating 25(OH)D level was associated with lower TSH levels with negative serum thyroid autoimmunity titres independent of thyroid hormones levels. This study did not find a link between Vitamin D status and thyroid autoantibody positivity.…”

Section: Introductionmentioning

confidence: 96%