Association of high alpha2-Heremans–Schmid glycoprotein/fetuin concentration in serum and intima-media thickness in patients with atherosclerotic vascular disease and low bone mass

Subclinical atherosclerosis and fetuin-A plasma levels in essential hypertensive patients

“…17 Fetuin-A is regarded as a marker for vascular inflammation and is one of the most potent negative regulators of vascular ossificationcalcification. 18,19 In fetuin-A-deficient mice, the aorta was found to be devoid of calcification and fibrosis, whereas the peripheral vessels in the skin and kidney showed evidence of extensive calcification; furthermore, the small artery involvement preceded the impairment of renal function. 17,18,20 The data presented herein support the relationship between fetuin-A and IMT, suggesting that decreases in the fetuin-A level could have a role in the development of the vascular changes that are peculiar to hypertensive patients; this role appears to be independent of other confounding factors, such as renal function.…”

Fetuin-A and CD40 L plasma levels in acute ischemic stroke: Differences in relation to TOAST subtype and correlation with clinical and laboratory variables

“…Recent investigations have focused on the potential role of Fetuin-A or alpha2-Heremans-Schmid glycoprotein (AHSG) as a non-traditional cardiovascular risk factor [1]. Fetuin-A is a member of the cystatin superfamily of cysteine protease inhibitors [2], it is expressed in the adult liver and accumulates in the skeleton during mineralization, due to its high affinity for hydroxyapatite [2].…”

The Relationship Between Fetuin-A and Bone Mineral Density in Postmenopausal Osteoporosis

“…Although recent in vivo studies have supported a role for the fetuin-A glycoprotein in Fetuin A ng/ml femur neck Z score regulating bone mineralization, its function has not been completely described. [10][11][12][13][14][15][16][17][18][19][20] Fetuin-A is a glycoprotein that is associated with bone formation and remodeling. [21,22] Previous studies have shown a correlation between serum Ca and serum fetuin-A concentrations during bone development in animal models.…”

“…[11] The relationship between BMD and vascular calcification has been previously demonstrated, and many studies have examined fetuin-A concentrations within the framework of this relationship. [8,[11][12][13][14][15][16][17][18] Kirkpantur et al [12] investigated the relationship between BMD parameters, coronary artery calcification (CAC), and serum fetuin-A concentrations in a group of patients who had participated in a hemodialysis (HD) program, and the proximal radius, femoral trochanter, and lumbar spine T scores were found to be lower in the patients with low serum fetuin-A levels.…”

“…[23][24][25][26][27][28][29][30][31][32] Several previous studies also indicated a relationship between fetuin-A levels and BMD, but to our knowledge, only two studies directly evaluated the relationship between fetuin-A levels and BMD without the presence of any disease (i.e., end-stage renal disease or cardiovascular disease). [12][13][14] A previous study by Ix et al [15] also investigated the relationship between serum fetuin-A concentrations and BMD in a study group that included a total of 580 Caucasian and African-American participants (257 females and 251 males; age range 70-79 years). Their serum fetuin-A concentrations were measured using the ElISA method, and the BMD was measured in the proximal femur, total femur, AP lumbar spine, and whole body using dualenergy X-ray absorptiometry (DXA).…”