Subclinical atherosclerosis and fetuin-A plasma levels in essential hypertensive patients

Abstract

The intima-media thickness (IMT) is considered as a surrogate marker for atherosclerotic disease. The aim of this study was to analyze the relationship of carotid IMT with fetuin-A in patients with essential hypertension (EH) and normal renal function. The plasma levels of fetuin-A, interleukin 6 (IL-6), tumor necrosis factor-a (TNF-a) and the biomarker of oxidative stress 8-isoPGF2alpha were assayed in samples from 105 untreated EH patients. Carotid IMT measurements were also performed. EH was studied overall and after dividing in EH with IMT X and o0.9 mm. All of the biomarkers were significantly different between the two subgroups, in particular, the fetuin-A level was lower in the patients with an IMT X0.9 mm. In the overall group, the linear analysis of correlation demonstrated that the IMT was significantly inversely correlated with the fetuin-A level (r ¼ À0.40, Po0.0001) and directly with TNF-a (r ¼ 0.39, Po0.0001), IL-6 (r ¼ 0.38, Po0.0001) and 8-iso-PGF2alpha (r ¼ 0.356, Po0.0003). The multiple regression analysis performed that assigned IMT as a dependent variable showed that fetuin-A (b ¼ À0.268, Po0.0001) was independently correlated with the IMT. Receiver-operator curves demonstrated that fetuin-A levels have a predictive power of IMT40.9 mm (AUC (area under the curve) 0.738, Po0.0001). Our results suggest that in EH, fetuin-A is associated with the IMT independently of oxidative stress and renal function, thus predicting increases in the IMT.

Prostaglandin F2α Facilitates Hepatic Glucose Production Through CaMKIIγ/p38/FOXO1 Signaling Pathway in Fasting and Obesity

“…PGF 2a is a potent luteolytic agent that is also involved in modulating intraocular pressure and smooth muscle contraction in the uterus (11), with PGF 2a analogs, such as latanoprost, used in medicine to treat glaucoma (33). However, exaggerated PGF 2a production has been observed in patients experiencing rheumatic diseases (34), essential hypertension (35), obesity (36), and diabetes (37). Furthermore, FP deficiency reduces blood pressure and retards attendant atherogenesis in hyperlipidemic mice 9).…”

Associations of fetuin-A and osteoprotegerin with arterial stiffness and early atherosclerosis in chronic hemodialysis patients

“…Studies investigating the above association are limited and the results are inconsistent. A recent study in patients with essential hypertension and normal renal function showed an independent negative correlation of fetuin-A with carotid IMT [26]. However, an earlier study in community-living individuals without prevalent CVD failed to demonstrate a similar association [19], while in 90 patients with carotid or femoral atherosclerosis and preserved renal function a positive correlation was observed [27].…”

Assessment Of Fetuin-A In Patients With Comorbidity Of Non-Alcoholic Fatty Liver Disease And Arterial Hypertension

“…У дослідженні Guarneni, 2013, рівні фет-A мали зворотній кореляційний зв'язок з товщиною КІМ у пацієнтів з АГ без ОЖ. Доведено, що рівні фет-A мали предикторну силу при КІМ ЗСА більше 0,9 мм [10].…”