Association of Helicobacter pylori positivity with the symptoms in patients with hyperemesis gravidarum

Güngören, Arif; Bayramoğlu, Neslihan; Duran, Nizami; Kurul, Mehmet

doi:10.1007/s00404-013-2869-x

Cited by 13 publications

(16 citation statements)

References 21 publications

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“…In their study of pregnant women who have HG, Güngören et al (2013) divided the subjects into three groups according to the severity of their symptoms: mild, moderate, and severe. They found that 21 (87.5%) of the participants with severe HG symptoms had an elevated H. pylori positivity rate (P = 0.001), suggesting that HG positively correlates with H. pylori infection.…”

Section: Discussionmentioning

confidence: 99%

Hyperemesis Gravidarum in First-Trimester Pregnant Saudi Women: Is Helicobacter pylori a Risk Factor?

Hussein

2020

Front. Physiol.

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Introduction: Hyperemesis gravidarum (HG) is a serious complication of pregnancy involving nausea and vomiting which affects all facets of the lives of many women. Helicobacter pylori infection has been linked to HG in some regions of the world. However, the prevalence of H. pylori in Saudi Arabian pregnant women and its link to HG has not been the subject of previous research. Detecting and treating H. pylori infection in women early in their pregnancies may lower the likelihood of adverse maternal outcomes. This study aims to assess the connection between the pathogenesis of HG and H. pylori infection in this population. Methods: Forty-five pregnant women with HG were recruited from the outpatient clinic for antenatal care in the Gynecology and Obstetrics Department at King Abdulaziz University Hospital. Forty-five pregnant women without HG were matched as controls. Both groups underwent testing for the H. pylori antigen in stool samples. Results: A statistically significant difference (P < 0.05) was observed between the cases and controls in terms of the occurrence of H. pylori. Thirty-eight women in the HG group (84.4%) tested positive for H. pylori, while the same was true of only 20 of the controls (44.4%). The mean level of blood hemoglobin in positive cases was significantly lower than that in negative cases (9.56 ± 1.29 vs. 11.90 ± 1.18 g/dl, P = 0.012). Conclusion: H. pylori may play a contributing role in the presence of HG in the study population. It may be included with other investigations of HG, especially with cases that do not respond to conventional management and continue into the second trimester. Women with H. pylori were also more likely to suffer from anemia compared to those without the infection. For this reason, those working with pregnant women should pay close attention to those infected with H. pylori. Additional large case-control studies are necessary to better understand the part H. pylori plays and the pathogenesis of HG.

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Section: Discussionmentioning

confidence: 99%

Hyperemesis Gravidarum in First-Trimester Pregnant Saudi Women: Is Helicobacter pylori a Risk Factor?

Hussein

2020

Front. Physiol.

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“…Of note, Cevrioglu et al [ 30 ] collected both serum and feces samples from pregnant women with HG to investigate specific antibodies for H. pylori (immunoglobulin-IgG, IgA) and HpSA, and only HpSA test suggested significant association between H. pylori infection and HG while serologic assessment failed to reflect the association (40% versus 12.4%, P < 0.001). By using PCR with specimen of saliva, Güngören et al [ 42 ] found a positive relationship between the symptoms of HG and H. pylori positivity, while test of H. pylori IgG/IgM antibody failed to detect this association between the symptoms of HG and H. pylori positivity. From biopsies of the gastric antrum and corpus, Bagis et al [ 23 ] found that, compared to controls, HG patients were detected with higher H. pylori density, degree of inflammation, and H. pylori activation, implying that H. pylori density might be related to HG since the bacterium density of controls was lower.…”

Section: Discussionmentioning

confidence: 99%

Helicobacter pyloriInfection Is Associated with an Increased Risk of Hyperemesis Gravidarum: A Meta-Analysis

Zhou

Xiao

et al. 2015

Gastroenterology Research and Practice

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Background. Several studies have shown a possible involvement of Helicobacter pylori (H. pylori) infection in individuals with hyperemesis gravidarum (HG), but the relationship remains controversial. This meta-analysis was performed to validate and strengthen the association between HG and H. pylori infection. Methods. PubMed, Embase, and Web of Science databases up to March 20, 2014, were searched to select studies on the prevalence of H. pylori infection between pregnant women with HG and the normal pregnant control subjects. Results. Of the HG cases, 1289 (69.6%) were H. pylori-positive; however, 1045 (46.2%) were H. pylori-positive in control group. Compared to the non-HG normal pregnant controls, infection rate of H. pylori was significantly higher in pregnant women with HG (OR = 3.34, 95% CI: 2.32–4.81, P < 0.001). Subgroup analysis indicated that H. pylori infection was a risk factor of HG in Asia, Africa, and Oceania, especially in Africa (OR = 12.38, 95% CI: 7.12–21.54, P < 0.001). Conclusions. H. pylori should be considered one of the risk factors of HG, especially in the developing countries. H. pylori eradication could be considered to relieve the symptoms of HG in some intractable cases.

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“…This particular complication affects 0.3 to 2.0% of all pregnancies. Previous studies showed that HG has a strong correlation with H. pylori infection [ 5 , 6 ].…”

Section: Introductionmentioning

confidence: 99%

Burden of Helicobacter pylori Infections and Associated Risk Factors among Women of Child Bearing Age in Addis Ababa, Ethiopia

Kitila

Sori

Desalegn

et al. 2018

International Journal of Chronic Diseases

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Background Early detection and treatment of Helicobacter pylori (H. pylori) infection in women of child bearing ages may reduce the risk of maternal health disorder. This study was conducted to determine the burden of H. pylori infections and associated risk factors among women of child bearing ages in Kolfe Keranio Subcity Woreda 9 Health Centers, Addis Ababa, Ethiopia. Methods Facility based cross sectional study design was conducted from April to October 2015. The study recruited 195 pregnant and 137 nonpregnant women with age range of 16-40 years. Sociodemographic data of study participants were collected by structured questionnaire. Venous blood was analyzed to determine hemoglobin, H. pylori stool antigen test kit was used to assess H. pylori infection, and fresh fecal (stool) was used to examine intestinal parasites among study subjects. Data was entered and analyzed using SPSS version 19. Bivariate and multivariate logistic regression model using odds ratio (OR) at 95% confidence interval (CI) were calculated. P-value less than 0.05 was taken as statistically significant. Results The overall burden of H. pylori infection among study participants was 29% (96/332). H. pylori infection was statistically significantly associated with pregnancy status (AOR: 1.825, CI (1.42-2.15), P=0.020), history of hyperemesis gravidarum (AOR=7.028, C.I (2.47-19.99), P=0.018), and low hemoglobin value (AOR=0.177, CI (0.083–0.379), p=0.003). There was no statistically significant association between H. pylori infection and sociodemographic characteristics and some expected risk factors like smoking, Khat chewing, alcohol drinking habit, and presence of intestinal parasites. Conclusion In this study, H. pylori infection was still a public health problem in the study area. H. pylori infected women also had high rate of anemia compared to women who had not H. pylori infected. Hence clinician and other responsible bodies should give a special attention for women who had been infected with H. pylori. Further large case control studies are warranted to understand more the role of H. pylori, HG, and other associated risk factors.

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Association of Helicobacter pylori positivity with the symptoms in patients with hyperemesis gravidarum

Abstract: A positive relationship between the symptoms of HG and Hp positivity was determined using PCR.

Cited by 13 publications

References 21 publications

Hyperemesis Gravidarum in First-Trimester Pregnant Saudi Women: Is Helicobacter pylori a Risk Factor?

Hyperemesis Gravidarum in First-Trimester Pregnant Saudi Women: Is Helicobacter pylori a Risk Factor?

Helicobacter pyloriInfection Is Associated with an Increased Risk of Hyperemesis Gravidarum: A Meta-Analysis

Burden of Helicobacter pylori Infections and Associated Risk Factors among Women of Child Bearing Age in Addis Ababa, Ethiopia

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