Association of Helicobacter pylori infection with metabolic parameters and dietary habits among medical undergraduate students in southeastern of Iran

Eslami, Omid; Shahraki, Mansour; Shahraki, Touran; Ansari, Hossein

doi:10.4103/1735-1995.199091

Cited by 7 publications

(3 citation statements)

References 26 publications

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“…A similar conclusion was reported in another study based on biopsy analysis from patients with H. pylori infection [ 30 ]. This may be caused by H. pylori-induced interleukin-1 (IL-1), IL-6, tumor necrosis factor, interferon, and c-reactive protein, which can cause hepatocyte damage; another possible reason is that H. pylori infection can increase intestinal permeability and facilitate the passage of bacterial toxins through the portal vein to the liver [ 31 , 32 ]. It is worth noting that some inconsistent findings were also reported.…”

Section: Discussionmentioning

confidence: 99%

Is the Occurrence or Reversal of Nonalcoholic Fatty Liver Disease Associated with Long-Term Helicobacter pylori Infection among Chinese Adults? A Cohort Study

Xia-xia

Wang

Liu

et al. 2021

Gastroenterology Research and Practice

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Background. Previous studies have suggested a link between Helicobacter pylori (H. pylori) infection and nonalcoholic fatty liver disease (NAFLD), yet long-term follow-up studies to elucidate this association are lacking. We aimed to identify the relationship between NAFLD and H. pylori in these people. Methods. A total of 2,934 adults between June 2013 and October 2017 were collected; among them, 675 people met the requirements. People were assessed for H. pylori infection diagnosis as detected by the carbon-13 urea breath test; they were also assessed for NAFLD diagnosis by ultrasound. Results. H. pylori infection was present in 206 patients (30.5%), and 469 (69.5%) participants were classified as controls. Participants with H. pylori infection had a higher rate of incident NAFLD than those who were uninfected (37/206; 18% versus 73/469; 15.6%) ( p < 0.001 ). Compared with the control group, the recovery rate of NAFLD in the H. pylori+ve group was low (6/206, 2.9% versus 33/469, 7.0%) ( p < 0.001 ). Besides, the incidence of uric acid, postprandial blood glucose, TG, LDL-C, HDL-C, and fasting plasma glucose was significantly different between the two groups ( p < 0.001 ), but no difference was found in alanine aminotransferase (ALT), liver-total protein, urea nitrogen, and cholesterol ( p > 0.05 ). Conclusion. H. pylori infection was a risk factor for NAFLD and affected the occurrence or reversal of NAFLD, indicating that H. pylori infection eradication might play a role in reducing the risk of NAFLD.

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Section: Discussionmentioning

confidence: 99%

Is the Occurrence or Reversal of Nonalcoholic Fatty Liver Disease Associated with Long-Term Helicobacter pylori Infection among Chinese Adults? A Cohort Study

Xia-xia

Wang

Liu

et al. 2021

Gastroenterology Research and Practice

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“…In 2005, in a high endemic area from Saudi Arabia, out of 120 medical students, for which the C13-urea breath test was performed, the prevalence of HP infection was 35% [ 22 ]. In 2014, in Iran, out of 363 medical students tested for HP infection using the IgG serology, almost half of them (45.7%) had a positive test [ 23 ]. In Japan, the prevalence was lower: out of 449 students from medical school who were investigated using the rapid urease test or urine antibody, 7.3% were infected [ 24 ].…”

Section: Discussionmentioning

confidence: 99%

Helicobacter pylori infection and positive Rome IV criteria for functional dyspepsia in Romanian medical students

et al. 2021

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Recent data suggest that the prevalence of Helicobacter pylori (HP) infection in Romania has been declining in the last 30 years. However, there are no studies regarding HP prevalence among medical students. The objectives of this study were to estimate the prevalence of HP infection and assess the prevalence of dyspepsia in medical students and the relationship between dyspepsia and infection. We included 150 students from the Iuliu Hatieganu University of Medicine and Pharmacy of Cluj-Napoca, Romania (102 females and 48 males, mean age 21 years). Each student completed a lifestyle questionnaire, personal history, family history as well as the Rome IV questionnaire for functional dyspepsia. The status of HP infection was determined using the C13-urea respiratory test. The prevalence of HP infection was 25.33%, and 18% met the Rome IV criteria for functional dyspepsia. 37% of students with functional dyspepsia had a positive HP test. Of all students, 8% had a history of HP infection. Those with a history of HP infection had a 4.45% (95% CI 1.6 – 12.37) higher risk of having positive Rome IV criteria for functional dyspepsia than those with no previous history of infection (p=0.008). Thus, the present study adds to the body of evidence regarding HP prevalence among medical students, 25.33% being positive. We found no statistically significant correlation between HP infection and functional dyspepsia. Those with a history of HP infection had a higher risk of functional dyspepsia.

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“…[ 9 ] It also produces enzymes such as urease, catalase, protease, lipase, and phospholipase that may be involved in the pathogenesis of intestinal inflammation. [ 10 ]…”

Section: Introductionmentioning

confidence: 99%

Association between the treatment of rosacea and eradication of Helicobacter pylori infection

Hejazi¹,

Aghaei²,

Aghaei³

et al. 2023

Adv Biomed Res

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Background: Rosacea is a multifactorial skin inflammatory disorder with an unknown cure. Genetics and environmental factors such as microorganisms are involved in the rosacea etiology, for example, Helicobacter pylori have been suggested in rosacea progression. The present study investigated the relationship between H. pylori eradication and rosacea patient's improvement. Materials and Methods: H. pylori infection was investigated in 60 rosacea patients and 65 sex- and age-matched healthy control through enzyme-linked immunosorbent assay (ELISA) and HpSag tests. After infection confirmation, randomly half of the rosacea patients were treated for H. pylori eradication (test), and others received standard treatment (control). HpSag and ELISA tests were repeated after infection eradication and disease flow was surveyed for 60 days. The groups were compared using the ANOVA (Analysis Of Variance) test at the significant level of P < 0.05. Results: At the baseline, the mean of immunoglobulin G (IgG) (59.27 ± 41.4 RU/mL) and immunoglobulin M (IgM) (11.55 ± 6.1 RU/mL) in rosacea patients was higher than the level of IgG (41.38 ± 54.33 RU/mL) and IgM (8.11 ± 8.91 RU/mL) in healthy control ( P < 0.04) and ( P < 0.01), respectively. Also, the values for H. pylori infection were positive in all patients and 10 healthy controls. The mean titer of IgM and IgG in the test and control patients groups were different at baseline and after treatment. Furthermore, in the test patients group, the mean of IgG was reduced in active rosacea after treatment, and 63.9% of active patients showed rosacea remission after H. pylori eradication. Conclusion: Data suggest the exacerbating role of H. pylori in rosacea, and its eradication along with other therapeutic methods causes rosacea improvement.

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Association of Helicobacter pylori infection with metabolic parameters and dietary habits among medical undergraduate students in southeastern of Iran

Cited by 7 publications

References 26 publications

Is the Occurrence or Reversal of Nonalcoholic Fatty Liver Disease Associated with Long-Term Helicobacter pylori Infection among Chinese Adults? A Cohort Study

Is the Occurrence or Reversal of Nonalcoholic Fatty Liver Disease Associated with Long-Term Helicobacter pylori Infection among Chinese Adults? A Cohort Study

Helicobacter pylori infection and positive Rome IV criteria for functional dyspepsia in Romanian medical students

Association between the treatment of rosacea and eradication of Helicobacter pylori infection

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