Is the Occurrence or Reversal of Nonalcoholic Fatty Liver Disease Associated with Long-Term Helicobacter pylori Infection among Chinese Adults? A Cohort Study

Xia-xia, Zhao; Wang, Rui-Ling; Liu, Ming‐Hao; Huang, Xiaojun

doi:10.1155/2021/6696473

Cited by 4 publications

(8 citation statements)

References 44 publications

(54 reference statements)

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“…Characteristics of included studies are shown in Table 1 . Among them, 4 were cohort studies, 3 were case-control studies, and 27 were cross-sectional studies; 3 studies were published as abstracts and 31 as full texts; 25 studies were performed in Asia [ 17 – 41 ], 3 in North America [ 42 – 44 ], 2 in Africa [ 45 , 46 ], and 4 in Europe [ 47 – 50 ]. The publication date ranged from 2013 to 2022.…”

Section: Resultsmentioning

confidence: 99%

Relationship of Helicobacter pylori Infection with Nonalcoholic Fatty Liver Disease: A Meta-Analysis

Dong

et al. 2023

Canadian Journal of Gastroenterology and Hepatology

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Background and Aims. Helicobacter pylori (H. pylori) and nonalcoholic fatty liver disease (NAFLD) have become increasingly recognized, both of which affect human health globally. The association of H. pylori infection with NAFLD remains unclear. Methods. PubMed, EMBASE, and Cochrane Library databases were searched. Only a random-effects model was used. Odds ratios (ORs) and risk ratios (RRs) with 95% confidence intervals (CIs) were calculated for the combined estimates of raw data. Adjusted ORs (aORs) and hazard ratios (aHRs) with 95% CIs were calculated for the combined estimates of data adjusted for confounders. Results. Thirty-four studies with 218573 participants were included. Based on unadjusted data from 26 cross-sectional studies and 3 case-control studies, H. pylori infection was significantly associated with the presence of NAFLD (OR = 1.26, 95% CI = 1.17–1.36, P < 0.001 ). Based on adjusted data from 15 cross-sectional studies and 1 case-control study, H. pylori infection was significantly associated with the presence of NAFLD (aOR = 1.25, 95% CI = 1.08–1.44, P < 0.001 ). Compared with control subjects without NAFLD, patients with moderate (OR = 1.67, 95% CI = 1.17–2.39, P = 0.005 ) and severe (OR = 1.71, 95% CI = 1.30–2.24, P < 0.001 ) NAFLD, but not those with mild NAFLD (OR = 1.14, 95% CI = 0.9–1.45, P = 0.286 ), had significantly higher proportions of H. pylori infection. The association of H. pylori infection with the occurrence of NAFLD was statistically significant based on adjusted data from 3 cohort studies (aHR = 1.18, 95% CI = 1.05–1.34, P = 0.007 ), but not based on unadjusted data from 3 cohort studies (RR = 1.41, 95% CI = 0.80–2.48, P = 0.237 ). Conclusion. H. pylori infection is associated with NAFLD, especially moderate and severe NAFLD. The impact of H. pylori eradication on the prevention of NAFLD should be further explored.

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Section: Resultsmentioning

confidence: 99%

Relationship of Helicobacter pylori Infection with Nonalcoholic Fatty Liver Disease: A Meta-Analysis

Dong

et al. 2023

Canadian Journal of Gastroenterology and Hepatology

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“…The main and novel findings of this comprehensive meta-analysis that included 28 observational studies (24 cross-sectional and 4 longitudinal studies [55][56][57][58]…”

Section: Discussionmentioning

confidence: 99%

“…Figure 2 shows the forest plot and pooled estimates of the effect of H. pylori infection on the risk of developing MASLD in four retrospective Asian cohort studies. [55][56][57][58] These studies included a total pylori infection was significantly associated with a higher risk of developing incident MASLD (pooled random-effects HR 1.20, 95%CI…”

Section: H Pylori Infection and Risk Of Incident Masldmentioning

confidence: 99%

Relationship between Helicobacter pylori infection and risk of metabolic dysfunction‐associated steatotic liver disease: An updated meta‐analysis

Mantovani,

Lando,

Borella

et al. 2024

Liver International

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BackgroundRecent observational studies examining the association between Helicobacter pylori infection and the risk of metabolic dysfunction‐associated steatotic liver disease (MASLD) have reported conflicting results. We performed a meta‐analysis to quantify the magnitude of the association between H. pylori infection and the risk of MASLD.MethodsWe systematically searched three large electronic databases to identify eligible observational studies (published up to 30 November 2023) in which liver biopsy, imaging methods or blood‐based biomarkers/scores were used for diagnosing MASLD. Data from selected studies were extracted, and meta‐analysis was performed using common and random‐effects modelling. Statistical heterogeneity among published studies, subgroup analyses, meta‐regression analyses and publication bias were assessed.ResultsA total of 28 observational studies (24 cross‐sectional and 4 longitudinal studies) were identified, including 231 291 middle‐aged individuals of predominantly Asian ethnicity (~95%). Meta‐analysis of cross‐sectional studies showed that H. pylori infection was significantly associated with a small increase in the risk of prevalent MASLD (n = 24 studies; random‐effects odds ratio 1.11, 95% CI 1.05–1.18; I2 = 63%). Meta‐analysis of data from longitudinal studies showed that H. pylori infection was significantly associated with an increased risk of developing incident MASLD over a mean 5‐year follow‐up (n = 4 studies; random‐effects odds ratio 1.20, 95%CI 1.08–1.33; I2 = 44%). Sensitivity analyses did not modify these results. The funnel plot did not reveal any significant publication bias.ConclusionsH. pylori infection is associated with a mildly increased risk of prevalent and incident MASLD. Further well‐designed prospective and mechanistic studies are required to better decipher the complex link between H. pylori infection and the risk of MASLD.

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“…Patients with MAFLD had a higher prevalence of H. pylori infection (53.8% vs 26.8%, p<0.001), hypertension (20.3% vs 9.7%, p<0.001), diabetes (7.2% vs 9.7%, p<0.001), and eating out (41.7% vs 24.7%, p<0.001) compared to non-MAFLD subjects. MAFLD is more prevalent in male subjects (54.7% vs 24.2%, p<0.001), older subjects [(40 vs 32 (27)(28)(29)(30)(31)(32)(33)(34)(35)(36)(37)(38)(39), p<0.001)], and overweight subjects (30.0% vs 20.4%, p<0.001). MAFLD is less prevalent in subjects with regular exercise (16.1% vs 30.9%, p<0.001).…”

Section: Baseline Characteristics Of Enrolled Subjectsmentioning

confidence: 99%

“…34 H. pylori infection can result in a variety of gastrointestinal diseases like chronic gastritis, peptic ulcer, mucosaassociated lymphoid tissue and gastric cancer, and there is a close relationship between H. pylori and a variety of extragastrointestinal diseases such as unexplained iron deficiency anaemia, respiratory diseases and Mets such as coronary heart disease, idiopathic thrombocytopenic purpura, type 2 diabetes and hypertension. 35 Recent research has shown that H. pylori is strongly correlated with a mildly elevated risk of NAFLD, 36,37 and that H. pylori eradication treatment reduces the risk of NAFLD. Our study showed that H. pylori infection was an independent risk factor for patients with MAFLD.…”

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confidence: 99%

Prevalence and Risk Factors of Metabolic-Associated Fatty Liver Disease Among Hospital Staff

Zhang¹,

Zhang²,

Chen³

et al. 2023

DMSO

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Background:The prevalence of metabolism-related fatty liver disease (MAFLD) has been rarely reported in hospital staffs. The aim of this study was to assess the prevalence and risk factors for MAFLD in hospital staffs aged ≥18 years. Methods: Based on type B ultrasonic, hospital staffs who underwent medical examinations at the second Affiliated Hospital of Hainan Medical University from January 2022 to March 2022 were classified into health control group (661 subjects) and MAFLD group (223 subjects), demographic, biochemical and blood examination information were compared between 2 groups. Independent risk factors for MAFLD were determined by logistic regression. Predictive values of risk factors of MAFLD were evaluated by receiver operating characteristic (ROC) curves. Results: The prevalence of MAFLD was 33.7%. Older age (OR=1.08, p<0.001), H. pylori infection (OR=0.234, p=0.02), triglycerideglucose (TyG) (OR=7.001, p<0.001), low-density lipoprotein cholesterol (LDL-C) (OR=2.076, p=0.028), red blood cell (RBC) (OR=2.386, p=0.001), eating out (OR=0.048, p=0.001), regular exercise (OR=23.017, p<0.001), and overweight (OR=3.891, p=0.003) were independently associated factors for MAFLD. The AUC of model predicting MAFLD is 0.910 [95% CI (0.886, 0.934)], with 0.794 sensitivity, 0.908 specificity. The diagnostic value of model was higher in the female MAFLD group after stratified analysis according to gender. The model showed that TyG was the factor contributing more to MAFLD. The diagnostic value of TyG was higher in the female MAFLD group than male MAFLD group. Conclusion:The prevalence of MAFLD among hospital staffs was 33.7%. TyG can be used to predict MAFLD especially for female hospital staffs for early intervention.

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Is the Occurrence or Reversal of Nonalcoholic Fatty Liver Disease Associated with Long-Term Helicobacter pylori Infection among Chinese Adults? A Cohort Study

Cited by 4 publications

References 44 publications

Relationship of Helicobacter pylori Infection with Nonalcoholic Fatty Liver Disease: A Meta-Analysis

Relationship of Helicobacter pylori Infection with Nonalcoholic Fatty Liver Disease: A Meta-Analysis

Relationship between Helicobacter pylori infection and risk of metabolic dysfunction‐associated steatotic liver disease: An updated meta‐analysis

Prevalence and Risk Factors of Metabolic-Associated Fatty Liver Disease Among Hospital Staff

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