Association of Helicobacter pylori IgG Antibody with Microvascular Complications in Type II Diabetic Patients

Vafaeimanesh, Jamshid; Bagherzadeh, Mohammad; Damanpak, Vahid; Parham, Mahmoud

doi:10.9734/arrb/2015/11148

Cited by 5 publications

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“…It is more interesting to know that there is an association between diabetic complications, especially microvascular complications and HP infection. [ 42 ] For example, in Agrawal et al . 's study,[ 21 ] the association between nephropathy, retinopathy and neuropathy with HP infection was also observed and a strong association was seen with diabetic retinopathy, diabetic neuropathy and nephropathy.…”

Section: Discussionmentioning

confidence: 99%

Helicobacter pylori infection prevalence: Is it different in diabetics and nondiabetics?

Vafaeimanesh

Parham

Bagherzadeh

2015

Indian J Endocr Metab

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Background:Helicobacter pylori (HP) infection plays a significant role in the development of gastrointestinal complications and has a significant role in systemic inflammation. It has some extragastrointestinal manifestations like endocrine diseases. In this study, we aimed to compare the prevalence of HP infection in diabetic and nondiabetic individuals.Materials and Methods:In this cross-sectional study, 218 nondiabetic and 211 diabetic patients referring to Shahid Beheshti Hospital of Qom between March 2013 and 2014 were studied. The patients were divided into two HP+ and HP− groups based on serological immunoglobulin G antibody against HP and the association between diabetes, and HP infection was evaluated. Data were analyzed using independent t-tests, Chi-square, Fisher's exact and Mann–Whitney tests.Results:The prevalence of HP seropositive was 65.9% versus 50.5% in diabetic and nondiabetics, respectively, and the difference was statistically significant (P = 0.001).Conclusions:This study showed a higher prevalence of HP infection in diabetic patients.

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Section: Discussionmentioning

confidence: 99%

Helicobacter pylori infection prevalence: Is it different in diabetics and nondiabetics?

Vafaeimanesh

Parham

Bagherzadeh

2015

Indian J Endocr Metab

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“…As well known, IR forms the pathophysiological basis of MetS, and growing evidences have shown that H. pylori infection is associated with IR ( 24 , 25 ). Some researchers thought that H. pylori infection caused IR through insulin dysfunction in the liver, which is an important target organ for insulin, via the c-Jun/microRNA203/suppressor of cytokine signaling 3 pathway ( 11 ).…”

Section: Discussionmentioning

confidence: 99%

Association between Helicobacter pylori infection and metabolic syndrome and its components

et al. 2023

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Background and aimThe association between Helicobacter pylori (H. pylori) infection and metabolic syndrome (MetS) has been studied previously; however, the results remain controversial, which could be partly due to the different criteria used for defining MetS. We adopted five MetS criteria to provide better understanding of the association between H. pylori infection and MetS.MethodsPhysical examination data of 100,708 subjects were obtained from January 2014 to December 2018. MetS was defined based on five criteria including: International Diabetes Federation (IDF), The Third Report of the National Cholesterol Education Program Expert Panel, Adult Treatment Panel III (ATP III), Joint Statement of International Multi-Societies (JIS), Chinese Diabetes Society (CDS), and the Guidelines for the Prevention and Treatment of Type 2 Diabetes in China (2017 edition)(CDS DM). Multivariate logistic regression analysis was performed to elucidate the association between H. pylori infection and MetS and its components.ResultsThe prevalence of MetS defined assessed using IDF, ATP III, JIS, CDS and CDS DM criteria was 15.8%, 19.9%, 23.7%, 8.7% and 15.4%, respectively. In males, the prevalence of MetS assessed using the five criteria in H. pylori-positive group was higher than that in negative-group; however, in females, same results were obtained using the three international criteria. In males, the prevalence of all MetS components was found to be higher in the H. pylori-positive group than those in the negative group; however, in females, only the prevalence of dyslipidemia and waist circumferences exhibited significant differences. Multivariate logistic regression analysis revealed that H. pylori infection in males was positively correlated with MetS. Additionally, H. pylori infection was found to be positively correlated with the waist circumference in the general population, and with hypertension and hyperglycemia in males.ConclusionsH. pylori infection was found to be positively associated with MetS in males in China.

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“…Although some studies reported an association between H. pylori infection, and insulin resistance (IR) [30][31][32], the association between H. pylori infection, and IR remains controversial [30].…”

Section: Discussionmentioning

confidence: 99%

Preconception Helicobacter pylori infection might adversely affect pregnancy outcome

Hagras

Abdelazim

Abdou

et al. 2023

Preprint

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Background: The association between H. pylori infection, and adverse pregnancy outcomes is still controversial, and no available guidelines recommend screening for H. pylori infection before and/or during pregnancy. Objectives: To detect the incidence of Helicobacter pylori (H. pylori) in Egyptian pregnant women, and the adverse pregnancy outcomes associated with H. pylori infection. Methods: Data of 305 pregnant women with regular antenatal follow-up, and complete delivery records were finally analyzed in study to detect the incidence of H. pylori in Egyptian pregnant women, and the adverse pregnancy outcomes associated with H. pylori infection. The collected blood samples from the studied participants during the antenatal care were used for detection of anti-H. Pylori IgG. Participants were categorized according to anti-H. Pylori IgG to either H. Pylori-positive (study group), or H. Pylori-negative controls. Participants were followed-up in the antenatal clinics till delivery to detect any adverse outcome either during pregnancy and/or during delivery [i.e., hyperemesis gravidarum, iron deficiency anemia, preeclampsia, gestational diabetes mellitus, and preterm deliveries]. Results: The incidence of hyperemesis gravidarum, iron deficiency anemia, preeclampsia, gestational diabetes mellitus, and preterm deliveries was significantly higher in the studied H. Pylori-positive group (8.5%, 34.9%, 6.98%,13.18%, and 10.9% respectively) compared to H. Pylori-negative controls (1.14%, 19.3%, 1.7%, 3.4%, and 3.98%respectively), (P=0.002, 0.01, 0.02, 0.003, and 0.02, respectively). The H. Pylori-positive group had significantly higher odds, and risks of hyperemesis gravidarum [OR 8.1 (P=0.007), and RR 7.5 (P=0.008)], iron deficiency anemia [OR 2.2 (P=0.002), and RR 1.8 (P=0.002)], and preeclampsia [OR 4.3 (P=0.03), and RR 4.1 (P=0.03)] compared to H. Pylori-negative controls. The H. Pylori-positive group had also significantly higher odds, and risks of gestational diabetes mellitus [OR 4.3 (P=0.002), and RR 3.9 (P=0.003)], and preterm deliveries [OR 2.9 (P=0.02), and RR 2.7 (P=0.02)] compared to H. Pylori-negative controls. Conclusion: The incidence of hyperemesis gravidarum, iron deficiency anemia, preeclampsia, gestational diabetes mellitus, and preterm deliveries was significantly higher in the studied H. Pylori-positive participants compared to non-infected controls. The H. Pylori-positive group had significantly higher odds, and risks of hyperemesis gravidarum, iron deficiency anemia, preeclampsia, gestational diabetes mellitus, and preterm deliveries compared to H. Pylori-negative controls.

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Association of Helicobacter pylori IgG Antibody with Microvascular Complications in Type II Diabetic Patients

Cited by 5 publications

References 0 publications

Helicobacter pylori infection prevalence: Is it different in diabetics and nondiabetics?

Helicobacter pylori infection prevalence: Is it different in diabetics and nondiabetics?

Association between Helicobacter pylori infection and metabolic syndrome and its components

Preconception Helicobacter pylori infection might adversely affect pregnancy outcome

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