Association between Helicobacter pylori infection and metabolic syndrome and its components

Abstract

Background and aimThe association between Helicobacter pylori (H. pylori) infection and metabolic syndrome (MetS) has been studied previously; however, the results remain controversial, which could be partly due to the different criteria used for defining MetS. We adopted five MetS criteria to provide better understanding of the association between H. pylori infection and MetS.MethodsPhysical examination data of 100,708 subjects were obtained from January 2014 to December 2018. MetS was defined based on five criteria including: International Diabetes Federation (IDF), The Third Report of the National Cholesterol Education Program Expert Panel, Adult Treatment Panel III (ATP III), Joint Statement of International Multi-Societies (JIS), Chinese Diabetes Society (CDS), and the Guidelines for the Prevention and Treatment of Type 2 Diabetes in China (2017 edition)(CDS DM). Multivariate logistic regression analysis was performed to elucidate the association between H. pylori infection and MetS and its components.ResultsThe prevalence of MetS defined assessed using IDF, ATP III, JIS, CDS and CDS DM criteria was 15.8%, 19.9%, 23.7%, 8.7% and 15.4%, respectively. In males, the prevalence of MetS assessed using the five criteria in H. pylori-positive group was higher than that in negative-group; however, in females, same results were obtained using the three international criteria. In males, the prevalence of all MetS components was found to be higher in the H. pylori-positive group than those in the negative group; however, in females, only the prevalence of dyslipidemia and waist circumferences exhibited significant differences. Multivariate logistic regression analysis revealed that H. pylori infection in males was positively correlated with MetS. Additionally, H. pylori infection was found to be positively correlated with the waist circumference in the general population, and with hypertension and hyperglycemia in males.ConclusionsH. pylori infection was found to be positively associated with MetS in males in China.

Interactions between Helicobacter pylori infection and host metabolic homeostasis: A comprehensive review

“…25 Another more recent retrospective cross-sectional study in China reinforced these associations within the same population, utilizing five diagnostic criteria simultaneously (IDF, ATP III, JIS, CDS, and CDS DM). 26 In summary, the evidences support the positive associations between H. pylori infection and metabolic syndrome, as defined by multiple diagnostic criteria.…”

“…Numerous studies have investigated the association between H. pylori infection and insulin resistance, but the results remain conflicting. 26,50,51 A previous meta-analysis of 22 case-control studies involving 206,911 participants, covering the period from 1991 to January 2021, quantified a combined OR of 1.54 (95% CI: 1.19-1.98) for the association between H. pylori infection and insulin resistance. 25 In cohort studies, this meta-analysis determined a summarized HR of 1.31 (95% CI: 1.13-1.51) for the occurrence of insulin resistance in individuals with H. pylori infection.…”

Bioactive peptides as alternative treatment for Helicobacter pylori infection

“…Therefore, the search for new therapeutic strategies against H. pylori infection is highly significant [60][61][62][63][64]. Nevertheless, there is controversy about the need for H. pylori eradication treatment when patients do not manifest any relevant symptoms due to the fact that it has been observed that in some cases the eradication of H. pylori is associated with the rise of other pathologies such as metabolic syndrome, gastroesophageal reflux disease (GERD) and its consequences, including esophageal and gastric cardia glandular malignancies [65][66][67]. In children, eradication is not recommended and other guidelines must be followed in order to manage the infection [68][69][70][71].…”

The Role of Helicobacter pylori and Metabolic Syndrome-Related Mast Cell Activation Pathologies and Their Potential Impact on Pregnancy and Neonatal Outcomes

“…Emerging evidence highlights a strong connection between MetS and active H. pylori infections, with both disorders appearing to mutually influence their pathophysiology [11]. This infection is associated with MetS [12], and its eradication positively impacts MetS components [13]. Furthermore, H. pylori is a risk factor for CVD, and its eradication is considered safe from a cardiac standpoint [14].…”