Association of heavy metals and trace elements in renal cell carcinoma: A case-controlled study

Panaiyadiyan, Sridhar; Quadri, Javed Ahsan; Nayak, Brusabhanu; Pandit, Surabhi; Singh, Prabhjot; Seth, Amlesh; Shariff, A

doi:10.1016/j.urolonc.2021.11.017

Cited by 21 publications

(16 citation statements)

References 35 publications

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“…Amchandani et al discovered that copper deficiency inhibits cancer metastasis via modulating oxidative phosphorylation, with the AMPK/mTORC1 energy sensor as a critical downstream manner [ 47 ]. On the one hand, remarkably higher levels of copper level subsequently increased lipid peroxidation and regulated copper transport to overcome drug resistance in RCC patients [ 5 , 48 ]. On the other hand, the OS and PFS Cox results indicated the most significant prognostic differences of CEScore in KIRC ( p < 0.001, Fig.…”

Section: Discussionmentioning

confidence: 99%

Pan-cancer analysis of cuproptosis regulation patterns and identification of mTOR-target responder in clear cell renal cell carcinoma

Long

Wang²,

Chen³

et al. 2022

Biol Direct

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Background The mechanism of cuproptosis, a novel copper-induced cell death by regulating tricarboxylic acid cycle (TCA)-related genes, has been reported to regulate oxidative phosphorylation system (OXPHOS) in cancers and can be regarded as potential therapeutic strategies in cancer; however, the characteristics of cuproptosis in pan-cancer have not been elucidated. Methods The multi-omics data of The Cancer Genome Atlas were used to evaluate the cuproptosis-associated characteristics across 32 tumor types. A cuproptosis enrichment score (CEScore) was established using a single sample gene enrichment analysis (ssGSEA) in pan-cancer. Spearman correlation analysis was used to identify pathway most associated with CEScore. Lasso-Cox regression was used to screen prognostic genes associated with OXPHOS and further construct a cuproptosis-related prognostic model in clear cell renal cell carcinoma (ccRCC). Results We revealed that most cuproptosis-related genes (CRGs) were differentially expressed between tumors and normal tissues, and somatic copy number alterations contributed to their aberrant expression. We established a CEScore index to indicate cuproptosis status which was associated with prognosis in most cancers. The CEScore was negatively correlated with OXPHOS and significantly featured prognosis in ccRCC. The ccRCC patients with high-risk scores show worse survival outcomes and bad clinical benefits of Everolimus (mTOR inhibitor). Conclusions Our findings indicate the importance of abnormal CRGs expression in cancers. In addition, identified several prognostic CRGs as potential markers for prognostic distinction and drug response in the specific tumor. These results accelerate the understanding of copper-induced death in tumor progression and provide cuproptosis-associated novel therapeutic strategies.

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Section: Discussionmentioning

confidence: 99%

Pan-cancer analysis of cuproptosis regulation patterns and identification of mTOR-target responder in clear cell renal cell carcinoma

Long

Wang²,

Chen³

et al. 2022

Biol Direct

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“…Another case study in India showed that people with 3.67 μg/L of mercury in their blood developed renal cancer compared to healthy individuals with only 0.36 μg/L. 135 As a well-known fact, epigenetics is a mandatory molecular complex event without any gene alterations. Mercury has been correlated to the interference of epigenetics by genetic modifications, including histone modification, RNA regulation, alternative RNA splicing, RNA stability, DNA methylation, DNA repair, transcription, gene copy number, and transposon activation.…”

Section: Pregnancy and Reproductive System Damagementioning

confidence: 99%

“…The study indicated that the concentration of total mercury in the hair of those farmers was 1.24 mg/kg, compared to just 0.49 mg/kg in the hair of healthy individuals. Another case study in India showed that people with 3.67 μg/L of mercury in their blood developed renal cancer compared to healthy individuals with only 0.36 μg/L …”

Section: Mercury Toxicity On Human Health: Effects and Molecular Mech...mentioning

confidence: 99%

The Toxicity of Mercury and Its Chemical Compounds: Molecular Mechanisms and Environmental and Human Health Implications: A Comprehensive Review

Wu,

Osman,

Hosny

et al. 2024

ACS Omega

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Mercury is a type of hazardous and toxic pollutant that can result in detrimental effects on the environment and human health. This review is aimed at discussing the state-of-the-art progress on the recent developments on the toxicity of mercury and its chemical compounds. More than 210 recent works of literature are covered in this review. It first delineates the types (covering elemental mercury, inorganic mercury compounds, organic mercury compounds), structures, and sources of mercury. It then discusses the pharmacokinetic profile of mercury, molecular mechanisms of mercury toxicity, and clinical manifestation of acute and chronic mercury toxicity to public health. It also elucidates the mercury toxicity to the environment and human health in detail, covering ecotoxicity, neurotoxicity diseases, neurological diseases, genotoxicity and gene regulation, immunogenicity, pregnancy and reproductive system damage, cancer promotion, cardiotoxicity, pulmonary diseases, and renal disease. In order to mitigate the adverse effects of mercury, strategies to overcome mercury toxicity are recommended. Finally, some future perspectives are provided in order to advance this field of research in the future.

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“…The age-standardized incidence rates of RCC in Taiwan in 2002 and 2012 were 3.39/10 6 and 5.09/10 6 , respectively [ 3 ]. RCC risk factors such as smoking, obesity, and comorbidities (e.g., diabetes, hypertension, and urolithiasis) are well recognized [ 4 ], and exposure to environmental contaminants such as cadmium may also increase the risk of RCC [ 5 , 6 ]. Exposure to cadmium is mainly from rice, which is the Taiwanese staple food [ 7 ].…”

Section: Introductionmentioning

confidence: 99%

Possible Combined Effects of Plasma Folate Levels, Global DNA Methylation, and Blood Cadmium Concentrations on Renal Cell Carcinoma

et al. 2023

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Epigenetic effects of environmental pollutants may be related to carcinogenesis. This study aimed to explore the association between the global DNA methylation marker: 5-methyl-2-deoxycytidine (5mdC) and renal cell carcinoma (RCC), and further investigated whether plasma folate and vitamin B12 levels and 5mdC modified the association between blood cadmium concentrations and RCC. We recruited 174 RCC patients and 673 non-RCC controls. Blood cadmium concentrations, plasma folate and vitamin B12 levels were measured. The amount of 5mdC in the DNA sample was expressed as percentages of the total cytosine content. An increase of 5mdC (%) and plasma folate and vitamin B12 levels were associated with decreasing odds ratio (OR) of RCC. Although plasma folate levels were not directly associated with 5mdC (%), a combined effect was observed with the odds of low plasma folate levels and low 5mdC (%) were greater among RCC patients compared to controls (OR (95% confidence interval, CI) = 11.86 (5.27–26.65)). Additionally, we observed that the odds of low plasma folate and high blood cadmium levels were greater among RCC patients than in controls (OR (95% CI): 8.15 (1.39–7.13)). This study provides suggestive evidence that plasma folate levels may modify the associations between 5mdC (%) or blood cadmium concentrations and RCC.

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Association of heavy metals and trace elements in renal cell carcinoma: A case-controlled study

Cited by 21 publications

References 35 publications

Pan-cancer analysis of cuproptosis regulation patterns and identification of mTOR-target responder in clear cell renal cell carcinoma

Pan-cancer analysis of cuproptosis regulation patterns and identification of mTOR-target responder in clear cell renal cell carcinoma

The Toxicity of Mercury and Its Chemical Compounds: Molecular Mechanisms and Environmental and Human Health Implications: A Comprehensive Review

Possible Combined Effects of Plasma Folate Levels, Global DNA Methylation, and Blood Cadmium Concentrations on Renal Cell Carcinoma

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