Association of heat shock protein70-2 (HSP70-2) gene polymorphism with coronary artery disease in an Iranian population

Mardan-Nik, Maryam; Pasdar, Alireza; Jamialahmadi, Khadijeh; Biabangard-Zak, Atefeh; Mirhafez, Seyed Reza; Ghalandari, Marzieh; Tajfard, Mohammad; Mohebati, Mohsen; Esmaily, Habibollah; Ferns, Gordon A.; Ghayour‐Mobarhan, Majid

doi:10.1016/j.gene.2014.08.012

Cited by 21 publications

(7 citation statements)

References 27 publications

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“…General demographic data including age, any drug, or supplement use, chronic diseases were collected as previously described [Mardan-Nik et al, 2014]. Waist circumference (WC) and systolic and diastolic blood pressure were measured as previously described [Mirhafez et al, 2016].…”

Section: Assessment Of Variablesmentioning

confidence: 99%

High Dose Supplementation of Vitamin D Affects Measures of Systemic Inflammation: Reductions in High Sensitivity C‐Reactive Protein Level and Neutrophil to Lymphocyte Ratio (NLR) Distribution

Tabatabaeizadeh

Rezayi

Bahrami

et al. 2017

J of Cellular Biochemistry

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The prevalence of Vitamin D deficiency is increasing worldwide, which has be shown to be associated with increased risk of cardiovascular disease (CVD), autoimmune disease, and metabolic syndrome. These conditions are also associated with a heightened state of inflammation. The aim of the current study was to evaluate the effect of vitamin D supplementation on serum C-Reactive Protein (CRP) level and Neutrophil-to-lymphocyte ratio (NLR) distribution in a large cohort of adolescent girls. A total of 580 adolescent girls were recruited follow by evaluation of CRP and hematological parameters before and after supplementation with vitamin D supplements as 9 of 50000 IU cholecalciferol capsules for 9 weeks taken at weekly intervals. At baseline, serum hs-CRP level was 0.9 (95%CI: 0.5-1.8), while this value after intervention was reduced to 0.8 (95%CI: 0.3-1.6; P = 0.007). Similar results were also detected for NLR (e.g., NLR level was 1.66 ± 0.72 and 1.53 ± 0.67, P = 0.002, before and after therapy with compliance rate of >95.2%). Moreover, we found an association between hs-CRP and BMI, triglyceride, white blood cell count, and lymphocytes. Interestingly we observed a significant reduction in neutrophil count and CRP level after high dose vitamin D supplementation. Our findings showed that the high dose supplementation of vitamin D affects measures of systemic inflammation: reductions in High Sensitivity C-Reactive Protein level and Neutrophil-to-lymphocyte ratio (NLR) distribution. J. Cell. Biochem. 118: 4317-4322, 2017. © 2017 Wiley Periodicals, Inc.

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Section: Assessment Of Variablesmentioning

confidence: 99%

High Dose Supplementation of Vitamin D Affects Measures of Systemic Inflammation: Reductions in High Sensitivity C‐Reactive Protein Level and Neutrophil to Lymphocyte Ratio (NLR) Distribution

Tabatabaeizadeh

Rezayi

Bahrami

et al. 2017

J of Cellular Biochemistry

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“…Therefore, it is essential to identify more genetic markers that can predict individual NIHL susceptibility potentially. The abnormity of HSP70 have been demonstrated to be related to many diseases, such as obesity [ 19 ], congenital sideroblastic anemia [ 20 ], coronary artery disease [ 21 ] and age-related cataract [ 22 ]. In the research field of NIHL, two studies both suggested an important role of HSP70 in the resistance to NIHL [ 12 , 23 ].…”

Section: Discussionmentioning

confidence: 99%

Association of polymorphisms in heat shock protein 70 genes with the susceptibility to noise-induced hearing loss: A meta-analysis

et al. 2017

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BackgroundSeveral case-control studies reported the relationship between single nucleotide polymorphisms (SNPs) in HSP70 genes and noise-induced hearing loss (NIHL). However, their conclusions are conflicting. This meta-analysis aims to identify the association of HSP70 variants and NIHL susceptibility.MethodA systematical literature search was performed in PubMed, Web of Science, EMBASE, and Wanfang Chinese database. The pooled odds radio (OR), 95% confidence interval (CI) and p value were calculated in fixed- or random-effects model according to the I2 value in the heterogeneity test.ResultsFour articles containing five studies, including 633 cases and 926 controls, were included. Under the allele, homozygote and dominant model, the pooled ORs (95%CI, p-value) of rs1061581 were 1.32 (1.06–1.67, p = 0.019), 1.93 (1.10–3.36, p = 0.021) and 1.455 (1.408–2.019, p = 0.025), respectively. In addition, a significant association was found between rs2227956 in Caucasians and the NIHL susceptibility under all five genetic models. We did not discover evidence sufficient to prove the associations between the other three SNPs (rs1043618, rs2763979 and rs2075800) and the NIHL susceptibility.ConclusionThis meta-analysis indicated that the two HSP70 variants, rs1061581 and rs2227956, may serve as genetic susceptibility factors for NIHL. Larger scale studies are required to further update the results.

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“…Moreover, in our recent study we reported an association between the HSP70-2 gene +1267A4G polymorphism and cardiovascular disease in 628 Iranian patients (Mardan-Nik et al, 2014). In the present study we have investigated further the relationship between HSP70-2 gene polymorphisms and obesity in an Iranian population with 317 subjects.…”

Section: Introductionmentioning

confidence: 78%

Association of heat shock protein70-2 (HSP70-2) gene polymorphism with obesity

Mardan-Nik

Pasdar

Jamialahmadi

et al. 2016

Annals of Human Biology

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Background: Obesity is a major risk factor of chronic-diseases, including cardiovascular-diseases (CVD). Increasing evidence is showing the association of heat-shock protein (HSP) with type-2 diabetes and CVD; however, there is little data on the relationship between the geneticpolymorphisms of HSP70-2 with obesity. Aim: The present study has investigated the association between 1267HSP70-2 genetic polymorphism and obesity in an Iranian population with 317 subjects. Subjects and methods: Anthropometric parameters and biochemical measurements were measured in all the samples, while genotypes were determined using PCR-RFLP. Univariate/ multivariate analyses were conducted to explore the relationship between the geneticpolymorphisms and obesity. Results: The data showed a significant association between 1267HSP70-2 polymorphism in obese subjects, compared to the non-obese group. Moreover, it was observed that this polymorphism was associated with obesity in the CAD + group, which had a high BMI compared to non-obese controls. Conclusion: The 1267HSP70-2 polymorphism is associated with obesity in an Iranian population, supporting a possible potential genetic link between obesity and cardiovascular diseases.

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Association of heat shock protein70-2 (HSP70-2) gene polymorphism with coronary artery disease in an Iranian population

Cited by 21 publications

References 27 publications

High Dose Supplementation of Vitamin D Affects Measures of Systemic Inflammation: Reductions in High Sensitivity C‐Reactive Protein Level and Neutrophil to Lymphocyte Ratio (NLR) Distribution

High Dose Supplementation of Vitamin D Affects Measures of Systemic Inflammation: Reductions in High Sensitivity C‐Reactive Protein Level and Neutrophil to Lymphocyte Ratio (NLR) Distribution

Association of polymorphisms in heat shock protein 70 genes with the susceptibility to noise-induced hearing loss: A meta-analysis

Association of heat shock protein70-2 (HSP70-2) gene polymorphism with obesity

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