Association of halo nevus/i and vitiligo in childhood: a retrospective observational study

Patrizi, Annalisa; Bentivogli, Margherita; Raone, Beatrice; Dondi, Arianna; Tabanelli, Michela; Neri, Iria

doi:10.1111/j.1468-3083.2012.04504.x

Cited by 26 publications

(20 citation statements)

References 17 publications

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“…The most typical location of HN was the posterior trunk [3], and generally the back [4] similar to our observation. Halo nevus occurred mainly as a solitary lesion [11], what was also shown in our conducted study. Multiple clinical presentation of HN is rather rare, and such manifestation suggests a higher risk of vitiligo and autoimmune disease development comparing to the solitary lesion [6].…”

Section: Discussionsupporting

confidence: 83%

“…study [11] the mean age of onset was 8 years. The mean age of patients with HN analyzed by dermoscopy was 18 years in our study, in whereas in Schwartz,s et al .…”

Section: Discussionmentioning

confidence: 99%

“…Patrizi et al . [11] suggested two different types of halo nevus in children: transient benign phenomena without any correlation with autoimmune disease, which is rather single and spontaneously regressive, and the second one combined with multiple halo nevi, which indicated an association with vitiligo, autoimmune disease and positive family history [11]. …”

Section: Discussionmentioning

confidence: 99%

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Dermoscopy of halo nevus in own observation

Kamińska‐Winciorek¹,

Szymszal²

2014

pdia

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IntroductionHalo nevus (HN) is a rare dermatologic entity characterized by a typical whitish rim encircling the existing melanocytic nevus resembling a halo. The clinical picture is suggesting its diagnosis, but so far only several dermoscopic descriptions of halo nevus have existed in the PubMed database.AimTo present the clinical and dermoscopic characteristics of halo nevus observed in dermoscopy.Material and methodsFifteen patients were diagnosed clinically and dermoscopically with halo nevus during planned routine dermoscopic examinations of all melanocytic lesions in 2007–2013. All digital images stored in the computer database were analyzed retrospectively according to the procedure described in the study. The clinical and dermoscopic parameters such as the dermoscopic pattern, color of nevus, special features and description of the surrounding halo were analyzed statistically.ResultsWe analyzed 22 halo nevi (9 in females, 13 in males) in 15 patients (7 females, 8 males) diagnosed during the dermoscopic examination. The mean age of patients during dermoscopic examinations was 18.2 years. Mean patients’ age at HN onset was 15.7 years. Halo nevi occurred the most often as a solitary lesion. The ratio of multiple halo nevi to solitary halo nevus was 5 : 10. Every third halo nevus was located on the posterior trunk upper. In 68.2% of HN cases, the surrounding rim (halo) was characterized by its homogenous, whitish color.ConclusionsDermoscopic patterns such as uniform globular and structureless constituted one-third each of them in all analyzed patterns.

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Section: Discussionsupporting

confidence: 83%

“…study [11] the mean age of onset was 8 years. The mean age of patients with HN analyzed by dermoscopy was 18 years in our study, in whereas in Schwartz,s et al .…”

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Dermoscopy of halo nevus in own observation

Kamińska‐Winciorek¹,

Szymszal²

2014

pdia

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“…Its etiology remains unknown, al- [5,6] . Taking into account the potential autoimmune substrate for vitiligo, we took note of 2 distinct neuroendocrine disorders in our patient that might have been contributing to, or at least be related to, the possible neuroendocrine/autoimmune reactions responsible for vitiligo.…”

Section: Discussionmentioning

confidence: 99%

Post-Finasteride Adverse Effects in Male Androgenic Alopecia: A Case Report of Vitiligo

Motofei

Rowland²,

Georgescu³

et al. 2017

Skin Pharmacol Physiol

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Finasteride has proved to be relatively safe and effective in the therapeutic management of male androgenic alopecia. However, literature data report several endocrine imbalances inducing various adverse effects, which often persist after treatment cessation in the form of post-finasteride syndrome. Here we present the case of a 52-year-old man receiving finasteride (1 mg/day) who developed an uncommon adverse effect represented by generalized vitiligo 2 months after finasteride discontinuation. Associated adverse effects encountered were represented by mild sexual dysfunction (as determined by the International Index of Erectile Function, IIEF) and moderate depressive symptoms (according to DSM-V criteria), all of these manifestations aggregating within/as a possible post-finasteride syndrome. Further studies should develop and compare several therapeutic approaches, taking into account not only compounds that decrease the circulating dihydrotestosterone level but also those that could block the dihydrotestosterone receptors (if possible, compounds with selective tropism towards the skin). In addition, the possibility of predicting adverse effects of finasteride (according to hand preference and sexual orientation) should be taken into account.

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“…A study of the prognostic value and clinical significance of halo nevi and vitiligo found the age of vitiligo onset among patients with halo nevi was significantly lower than patients without halo nevi (P< 0.001) [65•]. In addition, a recent retrospective observational study of 125 patients found patients with multiple halo nevi to have a higher risk of vitiligo and other autoimmune diseases than patients with a single halo nevus [66].…”

Section: Other Pigmented Lesionsmentioning

confidence: 99%

Literature Update on Melanocytic Nevi and Pigmented Lesions in the Pediatric Population

2012

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Pigmented lesions and melanocytic nevi are commonly evaluated lesions in pediatric dermatology clinics and the rising incidence of melanoma has increased public awareness of malignant potential. Diagnosis and management of pigmented lesions, especially dysplastic nevi, medium and large congenital melanocytic nevi (CMN), and Spitz nevi, can be particularly challenging. We summarize the recent literature for melanocytic nevi and pigmented lesions as relevant to the practice of pediatric dermatology with particular attention to dermatoscopic techniques, histopathologic interpretation, molecular biology, and management recommendations for CMN and Spitz nevi.

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Association of halo nevus/i and vitiligo in childhood: a retrospective observational study

Abstract: In patients with multiple HNi, the risk of vitiligo and other autoimmune diseases seems to be higher than in pediatric patients with a single HN; clinicians should pay particular attention to children with multiple HNi and personal or family history of autoimmune diseases.

Cited by 26 publications

References 17 publications

Dermoscopy of halo nevus in own observation

Dermoscopy of halo nevus in own observation

Post-Finasteride Adverse Effects in Male Androgenic Alopecia: A Case Report of Vitiligo

Literature Update on Melanocytic Nevi and Pigmented Lesions in the Pediatric Population

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