Association of GSTM1, GSTT1, GSTM3, and GSTP1 Genes Polymorphisms with Susceptibility to Osteosarcoma: a Case- Control Study and Meta-Analysis

Abstract

Background:Some studies have investigated the association of GSTM1, GSTT1, GSTM3, and GSTP1 polymorphisms with susceptibility to osteosarcoma; however, these studies results are inconsistent and inconclusive. In order to drive a more precise estimation, the present case-control study and meta-analysis was performed to investigate association of GSTM1, GSTT1, GSTM3, and GSTP1 polymorphisms with osteosarcoma.Methods:Eligible articles were identified by a search of several electronic databases for the period up to May 5, 2018. Odds ratios were pooled using either fixed-effects or random effects models.Results:Finally, a total of 24 case-control studies with 2,405 osteosarcoma cases and 3,293 controls were included in the present meta-analysis. Overall, significantly increased osteosarcoma risk was found when all studies were pooled into the meta-analysis of GSTT1 (Null vs. Present: OR= 1.247 95% CI 1.020-1.524, P= 0.031) and GSTP1 polymorphism (B vs. A: OR= 8.899 95% CI 2.722-29.094, P≤0.001). In the stratified, significantly increased osteosarcoma risk was observed for GSTT1 polymorphism among Asians (Null vs. Present: OR= 1.300 95% CI 1.034-1.635, P= 0.025), but not among Caucasians.Conclusions:This meta-analysis demonstrated that GSTP1 and GSTT1 null genotype are associated with the risk of osteosarcoma. Future large well-designed epidemiological studies are warranted to validate our results.

Association of IL-12B rs3212227 and IL-6 rs1800795 Polymorphisms with Susceptibility to Cervical Cancer: A Systematic Review and Meta-Analysis

“…Therefore, the assessment of heterogeneity is necessary, as high heterogeneity could be caused by the fact that there are actually two or more subgroups of studies present in the data, which have a different true effect. According to our previous metaanalyses, we suggested that heterogeneity might be due to differences in study design, sample size, genotyping methods, disease heterogeneity, and to the different roles played by gene-gene and gene-environment interactions (Aflatoonian et al, 2019a;Mirjalili et al, 2018;Moghimi et al, 2019Moghimi et al, , 2018. Moreover, after subgroup an analysis, heterogeneity was obviously decreased in Asians; however, the corresponding pooled ORs were not materially altered after deleting these studies, indicating that our results were statistically robust.…”

Research Article Evidence of association of glutathione-S-transferase <i>GSTT1</i> and <i>GSTM1</i> null genotypes with susceptibility to oral cancer based on meta-analysis

“…A recent meta-analysis, including 46 studies, concluded that GSTT1 and GSTM1 null genotypes are associated with an increased risk of developing hepatocellular carcinoma (Li et al, 2019). Another study showed the association of GSTT1 null genotype with a greater risk of developing osteosarcoma (Moghimi et al, 2019).…”

Pharmacogenomics and Pharmacogenetics in Osteosarcoma: Translational Studies and Clinical Impact

“…Polymorphisms of the GST family ( GSTP1 rs1695, GSTT1 and GSTM1 null allele, and GSTM3 rs1799735 were analyzed in a meta-analysis including 24 case-control studies with a total of 2405 HGOS cases and 3293 controls [ 38 ]. All five genetic models were tested.…”