Association of gout with osteoporotic fractures

Wang, Yanmao; Zhou, Runhua; Zhong, Wanrun; Hu, Chengfang; Lu, Shengdi; Chai, Yimin

doi:10.1007/s00264-018-4033-5

Cited by 21 publications

(19 citation statements)

References 35 publications

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“…Numerous quantitatively based studies debating the association between gout and the risk of fractures remain inconclusive. Tzeng et al [23] reported that gout history increased the fracture risk, which was consistent with the results of a Chinese adult-based research conducted by Wang et al [24]. However, the relationship became variable when focus on different fracture sites in the study performed by Paik et al [17], in which the risk of fractures raised in the hip but not in the wrist.…”

Section: Introductionsupporting

confidence: 73%

Gout is not associated with the risk of fracture: a meta-analysis

et al. 2019

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Background Numerous quantitatively based studies measuring the association between gout and the risk of fractures remain inconclusive. In order to determine whether gout could increase the risk of fractures, a meta-analysis was performed systematically. Methods Electronic databases, MEDLINE/PubMed, Embase, and Cochrane Library were systematically searched to identify studies evaluating the association of gout and the risk of fractures. No restrictions on language, publication date, or journal of publication were imposed. Meta-analysis was performed to pool the outcome estimates of interest such as fracture incidence, fracture risk, and fracture risk in different sites and at different time points in the follow-up period. Results Screening determined that seven studies involving a total of 684,964 participants (151,002 in the gout group and 533,962 in the control group) were deemed viable for inclusion in the meta-analysis. The results of the analysis showed that gout would not significantly have a relatively higher risk of any fracture (RR = 1.11, 95% CI 0.98–1.26). Subgroup analysis showed consistent results for sexuality (female: RR = 1.13, 95% CI 0.93–1.37; male: RR = 0.99, 95% CI 0.91–1.07) and several occurring sites (humerus, wrist, vertebra, hip, upper limbs, and lower limbs). Additionally, the results demonstrated that urate-lowering drugs prescribed early during disease had neither adverse nor beneficial effect on the long-term risk of fractures (RR = 0.89, 95% CI 0.76–1.05). Conclusions This meta-analysis confirmed that gout was not associated with an increased risk of fractures. Urate-lowering drugs prescribed early during the course of disease had neither adverse nor beneficial effect on the long-term risk of fractures. Electronic supplementary material The online version of this article (10.1186/s13018-019-1317-4) contains supplementary material, which is available to authorized users.

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Section: Introductionsupporting

confidence: 73%

Gout is not associated with the risk of fracture: a meta-analysis

et al. 2019

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“…Osteoporosis (OP) is a systemic bone disease characterized by bone mass reduction, bone strength reduction, and bone microstructure degeneration with the aging and aging of the human body, and it is also the main cause of high fracture incidence in recent years, which can lead to bone fragility and increased fracture risk (Wang et al, 2018; Watts, 2018). It has irreversible characteristics, and its early intervention methods have become a problem and focus of the whole society.…”

Section: Introductionmentioning

confidence: 99%

High-Throughput Metabolomics Evaluate the Efficacy of Total Lignans From Acanthophanax Senticosus Stem Against Ovariectomized Osteoporosis Rat

Zhang

Sun

et al. 2019

Front. Pharmacol.

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Postmenopausal osteoporosis (PMOP) is a common clinical illness in postmenopausal women, but there is no effective drug at present. Metabolomics approach was used to explore the potential biomarkers of PMOP and evaluate the efficacy and therapeutic targets of total lignans in the stem of Acanthophanax senticosus (ASSL) on the ovariectomized osteoporosis model rats. UPLC/MS and pattern recognition methods were used for serum metabolites discovery to illustrate the pathological mechanism of PMOP model rats, and then revealing the intervention effect of ASSL. The pattern recognition result showed that serum metabolic profiles of the sham operation group and the model group were clustered clearly, and 16 potential biomarkers were finally identified (7 in positive ion mode and 9 in negative ion mode), and they are involved in 15 related metabolic pathways. After oral administration of ASSL, 10 biomarkers were found to be significantly up-regulated and mainly regulated metabolic pathways include unsaturated fatty acid biosynthesis, linoleic acid metabolism, and arachidonic acid metabolism, primary bile acid synthesis, tyrosine metabolism, etc. Our study demonstrated that the ASSL could affect the endogenous metabolites related metabolic mechanism, provides a pharmacological basis of the ASSL for PMOP treatment.

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“…That might be another reason why risk of bone loss in these patients did not increase. A protective effect of uric acid (UA) on lumbar spine BMD has been reported in male patients [36] and hypothesized its potent antioxidant effect or via its interaction with the vitamin D/parathyroid hormone pathway [37], but high levels of serum UA (sUA) could cause oxidative stress and microinflammation as a pro-oxidant [38]; the role that high sUA/gout plays in OPF is also paradoxical [39][40][41]. In our study, likewise, hyperuricemia showed a positive effect on OP.…”

Section: Prevalence Of Bone Loss and Odd Ratiosmentioning

confidence: 99%

Prevalence and risk factors for bone loss in Southern Chinese with rheumatic diseases

et al. 2020

BMC Musculoskelet Disord

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Backgroud: This study is to explore the prevalence of different stages of bone loss and the potential risk factors in rheumatic patients. Method: A cross-sectional study recruits 1398 rheumatic patients and 302 healthy subjects. Demographic data, blood, and bone mineral density (BMD) tests are collected. Risk factors for bone loss in rheumatic patients are analyzed by logistic regression. Results: (1) Rheumatic patients are consisted of 40.0% rheumatoid arthritis (RA), 14.7% systemic lupus erythematosus (SLE), 14.2% osteoarthritis (OA), 9.2% ankylosing spondylosis (AS), 7.9% gout, 7.0% primary Sjogren syndrome (pSS), 3.8% systemic sclerosis (SSc), and 3.2% mixed connective tissue disease (MCTD). (2) In male patients aged under 50 and premenopausal female patients, the bone mineral density score of AS (53.9%, P < 0.001) and SLE (39.6%, P = 0.034) patients is lower than the healthy controls (18.2%). (3) Osteopenia and osteoporosis are more prevailing in male patients aged or older than 50 and postmenopausal female patients with RA (P < 0.001), OA (P = 0.02) and SLE (P = 0.011) than healthy counterparts. (4) Those with SLE, RA and AS gain the highest odd ratio of 'score below the expected range for age', osteopenia and osteoporosis, respectively. (5) Age, female, low BMI and hypovitaminosis D are found negatively associated with bone loss. Dyslipidemia and hyperuricemia could be protective factors. Conclusion: Young patients with AS and SLE have a significant higher occurrence of bone loss, and older patients with RA, OA and SLE had higher prevalence than healthy counterparts. SLE, RA, SSc and AS were founded significant higher risks to develop into bone loss after adjustment. Age, BMI and gender were commonly-associated with bone loss in all age-stratified rheumatic patients. These findings were not markedly different from those of previous studies.

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Association of gout with osteoporotic fractures

Abstract: In older Chinese adults, gout is significantly associated with the risk of osteoporotic fractures in women, especially those without rheumatic arthritis and in those with high TC levels or with osteoporosis.

Cited by 21 publications

References 35 publications

Gout is not associated with the risk of fracture: a meta-analysis

Gout is not associated with the risk of fracture: a meta-analysis

High-Throughput Metabolomics Evaluate the Efficacy of Total Lignans From Acanthophanax Senticosus Stem Against Ovariectomized Osteoporosis Rat

Prevalence and risk factors for bone loss in Southern Chinese with rheumatic diseases

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