Association of glycerol and paraffin in the treatment of ichthyosis in children: an international, multicentric, randomized, controlled, double‐blind study

Abstract

Dexeryl showed a significant improvement of xerosis and related symptoms in children with ichthyosis and was well tolerated.

Clinical Effectiveness of Moisturizers in Atopic Dermatitis and Related Disorders: A Systematic Review

“…In addition, there was a high risk of selection bias due to incomplete allocation concealment in one study [22] and a high risk of performance bias due to incomplete blinding of participants in one study [15]. Two studies had high drop-out rates that resulted in a high risk of attrition bias [33,35]. Taken together, a high risk of bias via at least one mechanism was encountered in five of the eight studies.…”

“…All were double-blind randomized controlled trials with approximately 4 weeks of follow-up. The largest of these studies included 231 children with ichthyosis and showed that glycerin reduced pruritus (p = 0.01) and increased the number of responders (60.3 vs. 43.5 %, p = 0.008) compared with vehicle alone [33]. In a study in 151 adult patients with AD, glycerin significantly reduced dryness and irritation as evaluated by a dermatologist (p = 0.0004) [29].…”

“…Four studies have compared glycerin-based emollients versus glycerin-free vehicle [28,29,33,34]. All were double-blind randomized controlled trials with approximately 4 weeks of follow-up.…”

“…The clinical effectiveness of glycerinbased emollients has been investigated in eight studies, including a total of 2029 subjects [16,22,24,28,29,[33][34][35]. In four of these studies, the risk of detection bias was deemed to be high, due to incomplete blinding of outcome assessment [15,16,22,35].…”

Burden of itch in ichthyosis: a multicentre study in 94 patients

“…However, itch has occasionally been reported as an additional parameter in several studies, for instance when investigating the effect of topical therapies in ichthyosis. In a study where an emollient cream was used to reduce the severity of ichthyosis, the cutaneous xerosis evolution was assessed as a primary criterion using the SRRC score and pruritus was assessed as a secondary criterion . On a visual analogue scale [VAS ranging from 0 (no itch) to 10 (very severe)], pruritus at baseline was scored 3.41 and 3.76 in the vehicle and treatment group, respectively.…”