Association of glutathione-S-transferase with patients of type 2 diabetes mellitus with and without nephropathy

Sharma, Monika; Gupta, Stuti; Singh, Kalpana; Mehndiratta, Mohit; Gautam, Amar; Kalra, Om Prakash; Shukla, Rimi; Gambhir, Jasvinder K.

doi:10.1016/j.dsx.2016.06.006

Cited by 35 publications

(20 citation statements)

References 25 publications

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“…Generally, oxidative stress happens when the proportion of production of ROS into the cell exceeds their normal rates, which leading to cellular and tissue damage (15). Therefore, imbalance of oxidants/antioxidant ratio causes an alteration in the normal redox signaling of the cell that induces impairment in several pathways of the cell’s metabolism.…”

Section: Oxidative Stress and Diabetesmentioning

confidence: 99%

An update on diabetic kidney disease, oxidative stress and antioxidant agents

et al. 2017

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Diabetes mellitus is a metabolic disease that is defined by relative or absolute deficiency of insulin secretion. Diabetic kidney disease seems to be one of the most frequent complications of diabetes mellitus. Based on evidence, increased free-radical formation and/or diminished antioxidant defenses induce oxidative stress that is implicated in the pathogenesis of diabetic kidney disease. It is evident that diabetic state induces oxidative stress through different signaling pathways as well as reactive oxygen species (ROS) formation that attributes to the activation of various downstream signaling cascade leading to structural the way to structural and functional changes in kidney.

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Section: Oxidative Stress and Diabetesmentioning

confidence: 99%

An update on diabetic kidney disease, oxidative stress and antioxidant agents

et al. 2017

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“…(24) Based on the data of standard methods of identification of early and late acquired GTD in patients with DCM and new methods for assessment of metabolic profile of urine, we propose new prognostic markers of renal glomerular and tubular lesions in patients with IGT and T2DM. The diagnostic markers of acquired GTD in patients with DCM interact with each other and with other molecules participating in universal pathways, which are the main causes for EMT formation and changes in ECM: Smad, p38 MAPK, TLRs, Wnt, mTOR, Notch, small GTPase and Hedgehog, and PI3K/ AKT signaling pathways.…”

Section: Discussionmentioning

confidence: 99%

Risk Prediction of Early and Late Acquired Glomerular and Tubular Dysfunctions in Patients with Disorders of Carbohydrate Metabolism

Ustinova¹,

Батюшин²,

Vorobyev³

et al. 2017

IJBM

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The purpose of this study was to create a new system for predicting the risk of glomerular and tubular dysfunctions (GTD) in patients with disorders of carbohydrate metabolism (DCM) based on standard parameters and new molecular markers for the development of kidney damage in patients with impaired glucose tolerance (IGT) and T2DM patients with diabetic nephropathy (DN).Material and Methods: The study included 69 patients: 16 patients with IGT (Group 1), 28 T2DM patients with microalbuminuria (Group 2), and 25 T2DM patients with macroalbuminuria (Group 3), according to the inclusion/exclusion criteria in the research. All patients were stratified by the MDRD. The control group (Group 4) included 11 healthy individuals. The duration of DN was 10.5 years. At the stage of data collection and screening, the standard methods of identification of IGT, DM and DN were applied. Additional methods are included quantitative analysis of the level of α-GST and π-GST, MMP-9 in urine by ELISA.Result: Based on the data of standard methods of identification of early and late acquired GTD in patients with DCM and new methods for assessment of metabolic profile of urine, we propose new prognostic markers of renal glomerular and tubular lesions in patients with IGT and T2DM. (International Journal of Biomedicine. 2017;7(3):208-212.)

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“…Finally, another interesting example that was identified as significant, both, in the clownfish LCA and in the meta-analysis, is GSTK1 encoding a glutathione-S-transferase that localizes to the peroxisome. GSTK1 was shown to be associated with diabetes type 2 which is another major aging related disease (54, 55).…”

Section: Analysis Of Positive Selectionmentioning

confidence: 99%

Clownfishes are a genetic model of exceptional longevity and reveal molecular convergence in the evolution of lifespan

Sahm

Almaida-Pagán

Bens

et al. 2018

Preprint

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10Standard evolutionary theories of aging postulate that reduced extrinsic mortality leads to evolution of 11 longevity. Clownfishes of the genus Amphiprion live in a symbiotic relationship with sea anemones that 12 provide protection from predation. We performed a survey and identified at least two species with 13 lifespan of over 20 years. Given their small size and ease of captive reproduction, clownfishes lend 14 themselves as experimental models of exceptional longevity. 15

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Association of glutathione-S-transferase with patients of type 2 diabetes mellitus with and without nephropathy

Cited by 35 publications

References 25 publications

An update on diabetic kidney disease, oxidative stress and antioxidant agents

An update on diabetic kidney disease, oxidative stress and antioxidant agents

Risk Prediction of Early and Late Acquired Glomerular and Tubular Dysfunctions in Patients with Disorders of Carbohydrate Metabolism

Clownfishes are a genetic model of exceptional longevity and reveal molecular convergence in the evolution of lifespan

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