2016
DOI: 10.1016/j.dsx.2016.06.006
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Association of glutathione-S-transferase with patients of type 2 diabetes mellitus with and without nephropathy

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Cited by 35 publications
(20 citation statements)
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References 25 publications
(24 reference statements)
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“…Generally, oxidative stress happens when the proportion of production of ROS into the cell exceeds their normal rates, which leading to cellular and tissue damage (15). Therefore, imbalance of oxidants/antioxidant ratio causes an alteration in the normal redox signaling of the cell that induces impairment in several pathways of the cell’s metabolism.…”
Section: Oxidative Stress and Diabetesmentioning
confidence: 99%
“…Generally, oxidative stress happens when the proportion of production of ROS into the cell exceeds their normal rates, which leading to cellular and tissue damage (15). Therefore, imbalance of oxidants/antioxidant ratio causes an alteration in the normal redox signaling of the cell that induces impairment in several pathways of the cell’s metabolism.…”
Section: Oxidative Stress and Diabetesmentioning
confidence: 99%
“…(24) Based on the data of standard methods of identification of early and late acquired GTD in patients with DCM and new methods for assessment of metabolic profile of urine, we propose new prognostic markers of renal glomerular and tubular lesions in patients with IGT and T2DM. The diagnostic markers of acquired GTD in patients with DCM interact with each other and with other molecules participating in universal pathways, which are the main causes for EMT formation and changes in ECM: Smad, p38 MAPK, TLRs, Wnt, mTOR, Notch, small GTPase and Hedgehog, and PI3K/ AKT signaling pathways.…”
Section: Discussionmentioning
confidence: 99%
“…Finally, another interesting example that was identified as significant, both, in the clownfish LCA and in the meta-analysis, is GSTK1 encoding a glutathione-S-transferase that localizes to the peroxisome. GSTK1 was shown to be associated with diabetes type 2 which is another major aging related disease (54, 55).…”
Section: Analysis Of Positive Selectionmentioning
confidence: 99%