2017
DOI: 10.15171/jrip.2017.30
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An update on diabetic kidney disease, oxidative stress and antioxidant agents

Abstract: Diabetes mellitus is a metabolic disease that is defined by relative or absolute deficiency of insulin secretion. Diabetic kidney disease seems to be one of the most frequent complications of diabetes mellitus. Based on evidence, increased free-radical formation and/or diminished antioxidant defenses induce oxidative stress that is implicated in the pathogenesis of diabetic kidney disease. It is evident that diabetic state induces oxidative stress through different signaling pathways as well as reactive oxygen… Show more

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Cited by 52 publications
(43 citation statements)
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“…Oxidative stress plays an essential role in the pathogenesis of different types of CKD, especially in diabetic nephropathy. Hyperglycemia induces autoxidation of glucose and glycosylation of proteins by the generation of reactive oxygen species, and increases oxidative stress[ 36 ]. Here, we have observed that coagonist increased SOD and CAT activity, and reduced TBARS content in kidney.…”
Section: Discussionmentioning
confidence: 99%
“…Oxidative stress plays an essential role in the pathogenesis of different types of CKD, especially in diabetic nephropathy. Hyperglycemia induces autoxidation of glucose and glycosylation of proteins by the generation of reactive oxygen species, and increases oxidative stress[ 36 ]. Here, we have observed that coagonist increased SOD and CAT activity, and reduced TBARS content in kidney.…”
Section: Discussionmentioning
confidence: 99%
“…In these complications, diabetic nephropathy is the main one which could lead to kidney failure [ 3 ]. Diabetic kidney disease is one of the critical problems of diabetes mellitus in which the prevalence has been increasing worldwide [ 4 ]. Diabetic nephropathy is a unique predictor of mortality in both insulin-dependent and insulin-independent diabetes [ 5 ].…”
Section: Introductionmentioning
confidence: 99%
“…Recent studies show that diabetes develops “oxidative stress.” Due to the reduction of antio-xidant status production of free radicals increases, enzymatic disorders that largely determine the secondary organ complications from diabetes [ 50 ]. Even with a normal level of LOW DENSITY LIPO-PROTEIN (LDL) there may be detectable markers of oxidation, such as antibodies to oxidized LDL and LDL-containing immune complexes, which seems a predisposing factor for the development of coronary artery lesions [ 51 ].…”
Section: Introductionmentioning
confidence: 99%