Association of Gestational Age and Severe Neonatal Morbidity with Mortality in Early Childhood

Stephens, Alexandre; Lain, Samantha J.; Roberts, Christine L.; Bowen, Jennifer R.; Nassar, Natasha

doi:10.1111/ppe.12323

Cited by 13 publications

(19 citation statements)

References 33 publications

(36 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Others have reported similar findings across different groups of specific CA . Prematurity is a major contributor of morbidity and mortality in infants and should also be taken into account when providing information on survival of infants diagnosed with CA. Inclusion of extremely preterm infants, particularly those less than 23 weeks gestation where active resuscitation and treatment is not usually performed and survival is rare, may also affect survival rates.…”

Section: Discussionmentioning

confidence: 55%

Five‐year survival of infants with major congenital anomalies: a registry based study

et al. 2019

Self Cite

View full text Add to dashboard Cite

Aim: To determine survival of infants with major congenital anomalies (CA) and assess the effect of co-existing anomalies and gestational age.Methods: All liveborn infants with major CA born in New South Wales (NSW), Australia, 2004Australia, -2009 were identified from the NSW Register of Congenital Conditions. Deaths were identified via record linkage to death registrations and five-year survival was estimated using Kaplan-Meier methods.Results: There were 8521 liveborn infants with CA of whom 617 (7.2%) died within the first five years of life. Half of deaths occurred in the first week of life. The overall five-year survival rate was 92.8% (95%CI: 92.2-93.3) and 83.2% (95%CI: 79.0-87.4) for syndromes, 83.4% (95%CI: 80.9-85.9) for multiple, 85.1% (95%CI: 82.6-87.5) for chromosomal, 95.3% (95%CI: 94.8-95.8) for isolated and 96.2% (95%CI: 94.3-98.1) for non-Q chapter anomalies. Five-year survival for chromosomal, syndromes and subgroups was higher for isolated compared with multiple anomalies ranging from 77.5% to 98.9% and 68.6% to 89.5%, respectively. Survival was lower for preterm (79.4%; 95%CI: 77.5-81.4) than for term infants (95.8%; 95%CI: 95.3-96.3). Conclusion:Nine in ten infants with major CA survive up to five years, although there is variability in survival across CA groups. Survival of infants with major congenital anomalies has improved in recent years.Abbreviations CA, Congenital anomalies; CI, Confidence interval; EUROCAT, European surveillance of congenital anomalies; NSW, New South Wales; RoCC, Register of congenital conditions. Key notesThis study suggests that nine in ten infants with major congenital anomalies survive past five years of age.Five-year survival ranged from 83% for infants with syndromes to more than 95% for infants with isolated and non-Q chapter anomalies (e.g. congenital hypothyroidism, cystic fibrosis) Five-year survival was higher for children with isolated than those with multiple anomalies, while survival rates were lower for preterm than term infants.2008

show abstract

Section: Discussionmentioning

confidence: 55%

Five‐year survival of infants with major congenital anomalies: a registry based study

et al. 2019

Self Cite

View full text Add to dashboard Cite

show abstract

“…Preterm birth, defined as birth prior to 37 completed weeks of gestation, is one of the strongest predictors for mortality and morbidity in infancy and early childhood (Costeloe et al, ; Liu et al, ; Luu et al, ; Stephens et al, ). Globally, 11% of all live births are preterm with variations from 18% in some African countries to 5% in the Scandinavian countries (Blencowe et al, ).…”

mentioning

confidence: 99%

Alcohol Intake in Early Pregnancy and Spontaneous Preterm Birth: A Cohort Study

Weile

Hegaard

et al. 2019

Alcoholism Clin & Exp Res

View full text Add to dashboard Cite

Background: Limited research has addressed whether maternal alcohol intake in early pregnancy increases the risk of spontaneous preterm birth. In the current study, we examined how alcohol binge drinking and weekly alcohol intake in early pregnancy were associated with spontaneous preterm birth in a contemporary cohort of Danish women.Methods: We included 15,776 pregnancies of 14,894 women referred to antenatal care at Copenhagen University Hospital, Denmark, between 2012 and 2016. Self-reported alcohol intake in early pregnancy was obtained from a Web-based questionnaire completed prior to the women's first visit at the department. Information on spontaneous preterm birth was extracted from the Danish Medical Birth Register. Adjusted hazard ratios (aHRs) with 95% confidence intervals (CIs) of spontaneous preterm birth according to self-reported alcohol binge drinking and weekly intake of alcohol in early pregnancy were derived from Cox regression.Results: Women reporting 1, 2, and ≥ 3 binge drinking episodes had an aHR for spontaneous preterm birth of 0.88 (95% CI 0.68 to 1.14), 1.34 (95% CI 0.98 to 1.82), and 0.93 (95% CI 0.62 to 1.41), respectively, compared to women with no binge drinking episodes. Women who reported an intake of ≥ 1 drink per week on average had an aHR for spontaneous preterm birth of 1.09 (95% CI 0.63 to 1.89) compared to abstainers. When restricting to nulliparous women or cohabiting women with ≥ 3 years of higher education, this estimate was 1.28 (95% CI 0.69 to 2.40) and 1.20 (95% CI 0.67 to 2.15), respectively.Conclusion: We found no evidence that maternal alcohol intake in early pregnancy was associated with a higher risk of spontaneous preterm birth, neither for alcohol binge drinking nor for a low average weekly intake of alcohol.

show abstract

“…These findings (coupled with other, similar studies) provide population-based evidence that SNM is associated with poor neurodevelopment and increased risk of mortality and morbidity in childhood. 11,12,24 Regardless of gestation or SGA, SNM was associated with increased odds of poorer outcomes. These associations were significant after adjusting for confounders and in the restricted analysis for special needs; overall development (DHR); developmental domains for language, cognition, communication, and physical health (which includes gross and fine motor skills); test exemption; and poor performance on standardized reading and numeracy tests.…”

Section: Discussionmentioning

confidence: 95%

Neonatal Morbidity at Term, Early Child Development, and School Performance: A Population Study

et al. 2018

Self Cite

View full text Add to dashboard Cite

show abstract

Association of Gestational Age and Severe Neonatal Morbidity with Mortality in Early Childhood

Cited by 13 publications

References 33 publications

Five‐year survival of infants with major congenital anomalies: a registry based study

Five‐year survival of infants with major congenital anomalies: a registry based study

Alcohol Intake in Early Pregnancy and Spontaneous Preterm Birth: A Cohort Study

Neonatal Morbidity at Term, Early Child Development, and School Performance: A Population Study

Contact Info

Product

Resources

About