Alcohol Intake in Early Pregnancy and Spontaneous Preterm Birth: A Cohort Study

Weile, Louise Katrine Kjær; Hegaard, Hanne Kristine; Wu, Chunsen; Tabor, Ann; Wolf, Hanne Trap; Kesmodel, Ulrik Schiøler; Henriksen, Tine Brink; Nøhr, Ellen Aagaard

doi:10.1111/acer.14257

Cited by 4 publications

(3 citation statements)

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“…We find an association between malaria infection and premature birth in a bivariate analyse and after accounting for cofounders. Similar findings have been demonstrated in a systematic review by Blencow,H atel in 2019 and another one in a study in Brazil by Jamille .D et al which showed an almost two time risk of premature birth in pregnant women infected with Plasmodium falciparum [20,21]. As stated by the WHO report 2020, malaria continue to infect for than 25 million pregnant women every year, making it one of the major public health problems, principally in Sub-Saharan Africa [22].…”

Section: Discussionsupporting

confidence: 74%

Prevalence and Risk Factors Associated with Preterm Birth at Irene-Neto Lubango Provincial Maternity- Huila /Angola

Francisco

Ussanje²,

Chitungu³

et al. 2022

JAMMR

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According to WHO (2018), almost 15 million babies are born every year before 37 weeks of pregnancy, the majority taking place in Sub Saharan Africa and in south Asia. Preterm birth is a common complication of pregnancy and usually bore heavy short- and long-term medical, socio-economic and financial burden to the affected children, the family, the heath system and the community as all. Angola with one of the highest fertility rates in the world, 6.2 according to the DHS 2015-2016, coupled with the fact that preterm birth is regarded as a traumatic social even for the parent and a quite expensive condition to the health system will need to stablish the main risk factors for preterm birth in order to inform strategies to prevent its occurrence. We conducted an hospital based cross sectional study to determine the prevalence and the risk factors of preterm birth at Irene Neto Maternity Hospital- Lubango-Angola. Three trained research assistants were recruited from the post labour wards and the new born unit and trained to collect data. Gestational age was calculated using a standard obstetric wheel based on menstrual dates or first trimester ultrasound (when available). A Newborn clinical assessment using the Finnstrom Score aided by a printed pictorial scoring chart was then conducted within 24 hours of birth, by a trained medical Doctor for confirmation. 17.7% of women giving birth at Lubango maternity hospital had a preterm new-born. Among the socio- demographics factors, only maternal age (p :0.021), family income(p:0.032), use of alcohol (p: 0.013) and lack ANC (p: <0.001) were associated with premature birth. Clinical factors found to increase the risk of premature birth included Antecedent of hypertension (p: 0.021), Preeclampsia (p: 0.026), Malaria (p:0.001) and multiple gestation (p: 0.01). Only antecedent of premature birth (p:0.0049), lack of antenatal care (p<0.001), malaria (p:0.009) and multiple gestation (p: 0.001) remained significant after controlling for confounders. Premature birth is still a public health problem in Angola, principally among pregnant women who do not attend ANC clinic and those with multiple gestation. Malaria infection during pregnancy as well as preeclampsia are also serious predictors of premature birth. With a prevalence of 17.7%, premature birth is a still a serious problem at lubangopediatric hospital and deserve a multisectoral well-coordinated action. ANC clinic should be actively promoted, improved and expended. Pregnant women with antecedent of premature birth should be closely monitored Preeclampsia and malaria should be prevented, searched and serious treated when present during pregnancy. We the recommend a Multicentre and large sample size, longitudinal observational analytic study for better understanding of the principal predictors at a country level.

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Section: Discussionsupporting

confidence: 74%

Prevalence and Risk Factors Associated with Preterm Birth at Irene-Neto Lubango Provincial Maternity- Huila /Angola

Francisco

Ussanje²,

Chitungu³

et al. 2022

JAMMR

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“…A study of over 4000 patients in West Australia who retrospectively reported their alcohol consumption during pregnancy did not observe any association with growth restriction but found that moderate-to-high PAE in early pregnancy was associated with increased odds of preterm delivery (O'Leary et al, 2009). Other studies, however, found no association between alcohol exposure in early pregnancy and spontaneous preterm delivery (Weile et al, 2020).…”

Section: Discussionmentioning

confidence: 97%

Dose–response effect of prenatal alcohol exposure on perinatal outcomes

Bakhireva,

Ma,

Wiesel

et al. 2024

Alcohol, Clinical and Experimental Research

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BackgroundA better understanding of the effects of lower levels of prenatal alcohol exposure (PAE), as a common exposure, is needed. The goal of this study was to examine the effects of mild–moderate PAE and episodic binge drinking on perinatal outcomes.MethodsThe data were obtained from three prospective cohorts with a combined sample of 281 participants: 125 with PAE and 156 without PAE. Alcohol‐related measures included the Alcohol Use Disorders Identification Test, timeline follow‐back questionnaires (covering the periconceptional period, mid‐gestation, and late gestation), and biomarkers. Absolute alcohol per day (AAD) and per drinking day (AADD), number of binge episodes, and maximum number of drinks in a 24‐h period were estimated. Perinatal outcomes included gestational age and anthropometric measures. Data were analyzed using correlation and multivariable regression analysis.ResultsAmong women with PAE, average alcohol consumption across the periconceptional period and pregnancy was 0.37 oz ± 0.74 AA/day (~5 drinks/week). After adjusting for tobacco co‐exposure and sociodemographic characteristics, significant associations between all alcohol measures and gestational age at delivery were observed, including cumulative measures of AAD (β = −0.58; 95% CI: −0.98; −0.17) and AADD (β = −0.58; 95% CI: −0.90; −0.26) during pregnancy and the periconceptional period. A significant association between the maximum number of drinks in a 24‐h period and birth length percentile (β = −0.70; 95% CI: −1.36; −0.04) was observed in the final model. PAE was associated with lower birth weight percentile in univariate analyses only.ConclusionsResults of this study demonstrate a negative association between mild–moderate PAE and episodic binge drinking with gestational age at delivery and birth length percentile after controlling for other factors. Robust negative effects of PAE, including in the periconceptional period before pregnancy recognition, on duration of gestation highlight the need for primary prevention efforts aimed at PAE in persons of reproductive age.

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“…Confounders and covariates were selected based on literature (Gegenhuber and Tollkuhn, 2020;Damoiseaux, 2017;Knickmeyer et al, 1991Knickmeyer et al, . 2017Hair et al, 2015;El Marroun et al, 2016;Cantacorps et al, 2018;Lautarescu et al, 2020;Soneji and Beltrán-Sánchez, 2019;Weile et al, 2020;Lee et al, 2012;Wang et al, 2010;Henshaw et al, 2021;Lahti-Pulkkinen et al, 2020). See Supplement for more information on the measurement method on each covariate and confounder.…”

Section: Confounders/covariatesmentioning

confidence: 99%