Association of genetic variants of the prolactin gene with milk production traits in Russian Red Pied cattle

Abstract

Prolactin plays an important regulatory function in mammary gland development, milk secretion, and expression of milk protein genes. Hence the PRL gene is a potential genetic marker of production traits in dairy cattle. The gene was mapped on chromosome 23 by Hallerman et al. (1988). It consists of 5 exons and four introns (Camper et al. 1984) encoding the 199-amino-acid mature protein (Wallis 1974). On the basis of sequence analysis of four different cDNA clones, seven possible nucleotide substitutions were described by Sasavage et al. (1982). One of them, recognized by RsaI endonuclease, has become a popular genetic marker used for genetic characterization of cattle populations by means of PCR-RFLP (Mitra et al., 1995). Two allelic variants (B and b) have been distinguished at the DNA level, based on RsaI polymorphism in the third exon of the coding region. It has been suggested that prolactin alleles correlate with milk yield (Lewin et al., 1992).

Prolactin gene polymorphism in Nili‐Ravi buffaloes in relation to Sahiwal and Achai Cattle

“…The results of the present study were also in contrast with those of Alipanah et al. (2007) where the frequency of allele A was found to be higher (0.794) than that of G allele (0.206) in Russians Red Pied cattle.…”

Genetic polymorphism of three genes associated with milk trait in Egyptian buffalo

“…In contrast to the results of Alipanah et al [2] which showed that the highest milk, milk fat yield and milk protein yield were obtained by cows with the genotype PRL-RsaI BB, different results for milk and milk fat were reported by Chung and Kim [10], Dybus [17] and Khatami et al [27] who found that cows with the PRL genotypes AA and AB yielded more milk fat than BB animals. The associations were analyzed between polymorphisms of the prolactin gene (PRL-RsaI) and milk production traits of Montebeliard cows [21].…”

Genetic mapping of quantitative trait loci for milk production in sheep

“…This QTL is of particular importance because the chromosomal region harbouring this QTL is in immediate proximity to the prolactin gene ( PRL ), which was shown to be associated with milk production traits in both sheep and cattle (Brym et al. 2005; Alipanah et al. 2007; Staiger et al.…”