Association of genetic variants of membrane receptors related to recognition and induction of immune response with Helicobacter pylori infection in Ecuadorian individuals

Abstract

Helicobacter pylori (Hp) has a worldwide distribution showing its higher prevalence of infection in developing countries. Toll-like receptors (TLRs) and C-type lectin receptors (CLRs) are proteins that recognize pathogen-associated molecular patterns (PAMPs) and initiate an innate immune response by promoting growth and differentiation of specialized hematopoietic cells for host defense. Gastric infections led by Hp induce a Th-1 cellular immune response, regulated mainly by the expression of IFN-γ. In this retrospective case-control study, we evaluated the TLR1 1805T/G, TLR2 2029C/T, TLR4 896A/G, CD209 -336A/G and IFNGR1 -56C/T polymorphisms and their relationship with susceptibility to Hp infection. TLR1 1805T/G showed statistical differences when the control (Hp-) and infected (Hp+) groups (P = 0.041*) were compared; the TLR1 1805G allele had a protective effect towards infection (OR = 0.1; 95% CI = 0.01-0.88, P = 0.033*). Similarly, the IFNGR1 -56C/T polymorphism showed statistical differences between Hp+ and Hp- (P = 0.018*), and the IFNGR1 -56TT genotype exhibited significant risk to Hp infection (OR = 2.9, 95% CI = 1.27-6.54, P = 0.018*). In conclusion, the pro-inflammatory TLR1 1805T and IFNGR1 -56T alleles are related with susceptibility to Hp infection in Ecuadorian individuals. The presence of these polymorphisms in individuals with chronic infection increases the risk of cellular damage and diminishes the cellular immune response efficiency towards colonizing agents.

Risk factors for recurrence of Helicobacter pylori infection after successful eradication in Chinese children: A prospective, nested case‐control study

“…genotype has been reported to be a risk factor for H pylori infection. 37 The present study revealed that the allele frequency G of the IFNGR1-56 site, the allele frequency A at the IFNGR1-600 site, and the allele frequency T of the IFNGR1-565 site were all significantly higher in the recurrence group when compared to the control group. This result showed that IFNGR1 polymorphism may leading to gastric tissue damage.…”

“…31,34 IFN-γ protects patients from H pylori infection and helps host remove H pylori. 35,36 37 Furthermore, this increases the body's susceptibility to H pylori infection. 40 The IFNGR1-56TT…”

“…IFN‐γ protects patients from H pylori infection and helps host remove H pylori 35,36 . Studies have found that Th‐1 cellular immune responses induced by H pylori infection are mainly regulated by IFN‐γ expression and that the level of IFN‐γ in children infected with H pylori is elevated 37,38 . Given the above, the abnormal level of inflammatory cytokines, including IL‐1β and IFN‐γ, may be associated with H pylori infection and recurrence.…”

Interacción de factores ambientales y genéticos asociados el desarrollo del cáncer de ovario

“…En el ambiente laboral existen compuestos perjudiciales como son las fibras de asbesto, talco, metales pesados, pesticidas, arsénico, benceno, xileno, tolueno, aminas aromáticas, monoclorhidrato de vinilo, hidrocarburos, radiación ionizante y radiación ultravioleta. Igualmente, existen agentes patógenos asociados al desarrollo del cáncer como son los virus (EBV, VPH, VHB, VHC, VTLH-1 o HHV8), o bacterias como el Helicobacter pylori (Cabrera-Andrade et al, 2014;Paz-y-Miño et al, 2008). El humo del tabaco es uno de los carcinógenos más potentes debido a sus componentes mutágenos como el hidrocarburo aromático policíclico (PAH) y la nitrosamina (Paz-y-Miño et al, 2010;Frank, 2007;Irigaray et al, 2007).…”

Toll-Like Receptors are Associated with Helicobacter pylori Infection and Gastric Mucosa Pathology

“…TLR1 is linked to H. pylori-associated gastric lesions (14,15). In a Chinese population, the association between SNPs in the promoter regions of TLR1 rs4833095 and TLR10 rs10004195 and susceptibility to H. pylori infection and precancerous gastric lesions or GC was studied (16)(17)(18).…”