Risk factors for recurrence of <i>Helicobacter pylori</i> infection after successful eradication in Chinese children: A prospective, nested case‐control study

Zhang, Yuanda; Dong, Qing-Wei; Tian, Lei; Zhang, Shaohui; Zuo, Naying; Zhang, Sisi; Ding, Zhaolu

doi:10.1111/hel.12749

Cited by 9 publications

(6 citation statements)

References 40 publications

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“… 17 A previous research by the members of our Research Group also revealed that the recurrence rate of Hp-infected children in the region was 18.8% after one year of successful eradication. 18 In the present study, the one-year recurrence rate in this region was 20.4%, which was consistent with previous reports, which may be explained by the underdevelopment of the local economy.…”

Section: Discussionsupporting

confidence: 93%

Correlation of iron deficiency indexes with Eradication and Recurrence of Helicobacter Pylori Infection in Children

Liu,

Zhang,

Dong

et al. 2024

Pak J Med Sci

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Objective: To explore the correlation of iron deficiency (ID) indexes with eradication and recurrence of Helicobacter pylori (Hp) infection in children. Methods: This is a clinical comparative study. One hundred and twenty-six children who were first diagnosed as Hp infection in Baoding Children’s Hospital (Hp infection group); and the control group included 200 children without Helicobacter Pylori infection (negative stool Hp antigen test and/or 13C-urea breath test) in local region at the same time from January 2020 to January 2022. Enrolled children were subjected to routine blood test, serum ferritin (SF), serum iron (SI) and total iron binding capacity (TIBC) detection. Meanwhile, children with Hp infection were given triple therapy for eradication and followed up for one year. Results: The levels of SI, SF and Hb in non-eradication group were lower than those in eradication group (P<0.05); while TIBC level in the former group was higher than that in the latter group (P<0.05). Furthermore, SF level in the recurrence group was lower than that in the non-recurrence group (P<0.05). While there was no significant difference in Hb, SI and TIBC levels between the recurrence group and the non-recurrence group (P>0.05). Conclusion: Low level of SF may be a risk factor for difficulty in eradication and recurrence after eradication in children with Hp infection. Meanwhile, low levels of Hb and SI are influential factors for difficulty in eradication in children with Hp infection. doi: https://doi.org/10.12669/pjms.40.4.7816 How to cite this: Liu X, Zhang Y, Dong Q, Deng H, Bi J. Correlation of iron deficiency indexes with Eradication and Recurrence of Helicobacter Pylori Infection in Children. Pak J Med Sci. 2024;40(4):674-678. doi: https://doi.org/10.12669/pjms.40.4.7816 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Section: Discussionsupporting

confidence: 93%

Correlation of iron deficiency indexes with Eradication and Recurrence of Helicobacter Pylori Infection in Children

Liu,

Zhang,

Dong

et al. 2024

Pak J Med Sci

Self Cite

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“…Drinking and dining out were independent risk factors of H. pylori recurrence. Consistent with this study, Zhang et al. (2020a) also reported a high annual H. pylori recurrence rate (18.8%) among children.…”

Section: Helicobacter Pylori Recurrencesupporting

confidence: 88%

“…Drinking and dining out were independent risk factors of H. pylori recurrence. Consistent with this study, Zhang et al (2020a) also reported a high annual H. pylori recurrence rate (18.8%) among children. The follow-up of these two studies was short (1 year) and the enrolled patients were limited to one region.…”

Section: Introductionsupporting

confidence: 88%

The management of Helicobacter pylori infection and prevention and control of gastric cancer in China

Zhu

Lü

2022

Front. Cell. Infect. Microbiol.

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Helicobacter pylori (H. pylori) infection, a type-1 carcinogen, was closely associated with gastric cancer (GC). Successfully eradicating H. pylori infection could reduce the incidence of GC. China was a country with high incidence of GC and high prevalence of H. pylori infection. Nearly half of worldwide GC new cases and deaths attributed to H. pylori infection occurred in China. H. pylori prevalence varied over time with the improvement of socioeconomic status and sanitary conditions. The knowledge of antibiotic resistance rate in time was important to guide the clinical choice of antibiotics use in the regimens. With the publication of five Chinese consensus reports on the management of H. pylori infection and the effort of public preach of H. pylori-related knowledge, the standardization of H. pylori diagnosis and treatment by clinicians was improved. Bismuth-containing quadruple therapy was widely applied in clinical practice of H. pylori eradication because of high efficacy and safety. High-dose Proton Pump Inhibitor-amoxicillin dual therapy or vonoprazan-amoxicillin dual therapy showed comparable efficacy and lower side effects than bismuth-containing quadruple therapy, which were the alternative choice. The diagnosis rate of early GC was low and distinguishing Chinese GC risk population for the further endoscopy screening was important. Efforts have been done to establish prediction models to stratify GC risk in the Chinese GC risk population. We reviewed the current situation of the management of H. pylori infection and prevention and control of GC in China here.

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“…However, in low socio-economic situations, reinfection can be as high as 23 %. Genetic factors may also play a role and susceptible individuals in whom H. pylori has been eradicated may be prone to reinfection when they are exposed to H. pylori-positive people (16,18). Recurrence during the first 3-12 months after cure is mostly due to failed eradication attempts (19).…”

Section: Strong Recommendation (100% Of Agreement) High Quality Evidencementioning

confidence: 99%

Belgian consensus for Helicobacter pylori management 2023

Garcés-Durán¹,

Kindt²,

Kotilea³

et al. 2023

AGEB

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Helicobacter pylori (H. pylori) infection causes chronic gastritis, peptic ulcers and gastric cancer. Although H. pylori prevalence is decreasing worldwide, regional variations exist in Europe, with the lowest infection prevalence in Northern Europe, and the highest in Eastern and Southern Europe (1). Changes in the treatment recommendations and the increasing available evidence have justified the implementation of new recommendations since last Belgian consensus in 1998 (2). Several non-H. pylori Helicobacter species (NH.PYLORI-H), colonizing the stomach of domestic animals, also have the ability to cause gastric disease in humans, although to a lesser extent. These zoonotic NH. PYLORIH are not the subject of the current recommendations.

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Risk factors for recurrence of Helicobacter pylori infection after successful eradication in Chinese children: A prospective, nested case‐control study

Cited by 9 publications

References 40 publications

Correlation of iron deficiency indexes with Eradication and Recurrence of Helicobacter Pylori Infection in Children

Correlation of iron deficiency indexes with Eradication and Recurrence of Helicobacter Pylori Infection in Children

The management of Helicobacter pylori infection and prevention and control of gastric cancer in China

Belgian consensus for Helicobacter pylori management 2023

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