Association of genetic variants of NOS1AP with type 2 diabetes in a Chinese population

Hu, Cheng; Zhang, R.; Ng, Maggie; Bao, Yuqian; Wang, C.; So, Wing Yee; Ma, R. C.; Ma, Xiaojing; Chan, Juliana C.N.; Xiang, Kun–san; Jia, Weiping

doi:10.1007/s00125-009-1594-2

Cited by 46 publications

(61 citation statements)

References 43 publications

(67 reference statements)

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“…Participants This study involved 1,972 patients with type 2 diabetes recruited from the Shanghai Diabetic Complications Study [19] and Shanghai Diabetes Institute Inpatient Database of Shanghai Jiao Tong University Affiliated Sixth People's Hospital [20,21]. All participants were unrelated patients with type 2 diabetes meeting the 1999 WHO criteria.…”

Section: Methodsmentioning

confidence: 99%

Common variants in or near ZNRF1, COLEC12, SCYL1BP1 and API5 are associated with diabetic retinopathy in Chinese patients with type 2 diabetes

et al. 2015

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Aims/hypothesis Three recent genome-wide association studies (GWAS) identified several single-nucleotide polymorphisms (SNPs) with modest effects on diabetic retinopathy in Mexican-American and white patients with diabetes. This study aimed to evaluate the effects of these variants on diabetic retinopathy in Chinese patients with type 2 diabetes. Methods A total of 1,972 patients with type 2 diabetes were recruited to this study, including 819 patients with diabetic retinopathy and 1,153 patients with diabetes of ≥5 years duration but without retinopathy. Forty SNPs associated with diabetic retinopathy in three GWAS were genotyped. Fundus photography was performed to diagnose and classify diabetic retinopathy. Results rs17684886 in ZNRF1 and rs599019 near COLEC12 were associated with diabetic retinopathy (OR 0.812, p=0.0039 and OR 0.835, p=0.0116, respectively) and with the severity of diabetic retinopathy (p=0.0365 and p=0.0252, respectively, for trend analysis). Sub-analysis in patients with diabetic retinopathy revealed that rs6427247 near SCYL1BP1 (also known as GORAB) and rs899036 near API5 were associated with severe diabetic retinopathy (OR 1.368, p=0.0333 and OR 0.340, p=0.0005, respectively). The associations between rs6427247 and rs899036 and severe diabetic retinopathy became more evident after a meta-analysis of published GWAS data (OR 1.577, p=2.01×10 −4 for rs6427247; OR 0.330, p=5.84×10 −7 for rs899036). Conclusions/interpretation We determined that rs17684886 and rs599019 are associated with diabetic retinopathy and that rs6427247 and rs899036 are associated with severe diabetic retinopathy in Chinese patients with type 2 diabetes.

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Section: Methodsmentioning

confidence: 99%

Common variants in or near ZNRF1, COLEC12, SCYL1BP1 and API5 are associated with diabetic retinopathy in Chinese patients with type 2 diabetes

et al. 2015

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“…Our present study included 340 unrelated nondiabetic individuals of Han Chinese ethnicity who had been enrolled in the community-based Shanghai Diabetes Studies [24,25]. The specified inclusion and exclusion criteria for all participants have been previously described [24,25].…”

Section: Methodsmentioning

confidence: 99%

“…All participants underwent detailed clinical investigations, as previously described [25]. The height and weight were obtained from all subjects.…”

Section: Methodsmentioning

confidence: 99%

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The Single Nucleotide Polymorphism rs499765 Is Associated with Fibroblast Growth Factor 21 and Nonalcoholic Fatty Liver Disease in a Chinese Population with Normal Glucose Tolerance

Jiang

Zhang

et al. 2014

Lifestyle Genomics

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Background: Fibroblast growth factor 21 (FGF21) is a hormone involved in the metabolism of carbohydrates and lipids. Increased circulating FGF21 levels are closely associated with nonalcoholic fatty liver disease (NAFLD). However, the association between genetic variations of FGF21 and NAFLD remains unknown. In our study, we aimed to investigate the association of these genetic variations with serum FGF21 levels and NAFLD. Methods: We genotyped four single nucleotide polymorphisms (SNPs) in FGF21 and its flanking region in 340 nondiabetic subjects. NAFLD was defined as the presence of a specific abdominal ultrasonographic pattern. Serum FGF21 concentrations were measured using an enzyme-linked immunosorbent assay kit. Results: We found significant evidence of an association with NAFLD for rs499765 (p = 0.039). After adjusting for age and sex, the effect of rs499765 on NAFLD remained significant (p = 0.045). However, after adjusting for multiple comparisons, no association was found. Moreover, rs499765 was associated with serum FGF21 levels (p = 0.030). In addition, both rs2071699 and rs838136 showed an association with serum aspartate aminotransferase levels (p = 0.049 and p = 0.047, respectively). The SNP rs838136 also showed a correlation with serum alanine aminotransferase concentrations after adjustment for body mass index (p = 0.034). We also combined the minor group with the heterozygous genotype and observed that rs499765 had an effect on FGF21 (p = 0.031). Conclusion: The variant rs499765 adjacent to FGF21 is associated with serum FGF21 levels and NAFLD in a Chinese nondiabetic population. © 2014 S. Karger AG, Basel

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“…8 The extensive work of the 1q21 consortium found association of a few genes with type 2 diabetes on chromosome 1 but could not provide a confirmatory signal. [8][9][10] Moreover, investigation of candidate genes on these regions have provided inconsistent and/or only modest association of a few genes including KCNJ9, 11 KCNJ10, 12 PKLR, 13 CRP, 14 LMNA, 15 CASQ1, 16 DUSP12, 17 HNF4A, 18 DOK5 19 and PTPN1 20 with type 2 diabetes. These candidate regions still remain unexplored in Indian population, which is a high-risk group for type 2 diabetes 21 that necessitates a systematic evaluation of these promising candidate regions in this population.…”

Section: Introductionmentioning

confidence: 99%

Common variants of SLAMF1 and ITLN1 on 1q21 are associated with type 2 diabetes in Indian population

et al. 2012

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Association of genetic variants of NOS1AP with type 2 diabetes in a Chinese population

Abstract: Our data suggest that NOS1AP variants may not play a dominant role in susceptibility to type 2 diabetes, but a minor effect cannot be excluded.

Cited by 46 publications

References 43 publications

Common variants in or near ZNRF1, COLEC12, SCYL1BP1 and API5 are associated with diabetic retinopathy in Chinese patients with type 2 diabetes

Common variants in or near ZNRF1, COLEC12, SCYL1BP1 and API5 are associated with diabetic retinopathy in Chinese patients with type 2 diabetes

The Single Nucleotide Polymorphism rs499765 Is Associated with Fibroblast Growth Factor 21 and Nonalcoholic Fatty Liver Disease in a Chinese Population with Normal Glucose Tolerance

Common variants of SLAMF1 and ITLN1 on 1q21 are associated with type 2 diabetes in Indian population

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