Association of genetic polymorphisms of MK, IL-4, p16, p21, p53 genes and human gastric cancer in Taiwan

Interleukin-4 and -8 Gene Polymorphisms and Risk of Gastric Cancer in a Population in Southwestern China

“…The IL-4-590 C>T polymorphism was not associated with either overall or subtype GC. This finding concerning overall GC risk was in agreement with that from studies in Chinese Taiwan (Wu et al, 2003;Lai et al, 2005), Spain (Garcia- Gonzalez et al, 2007), and Venezuela (Kato et al, 2006). Of note, the risk of the polymorphism remained nonsignificant even in a case-control analysis for HP infected patients and controls in a Japanese population (Ando et al, 2009).…”

“…Of note, the risk of the polymorphism remained nonsignificant even in a case-control analysis for HP infected patients and controls in a Japanese population (Ando et al, 2009). We observed that T was a dominant allele in Asian populations (Wu et al, 2003;Lai et al, 2005;Ando et al, 2009), but a minor one in European and African populations (Kato et al, 2006;Garcia-Gonzalez et al, 2007). Despite distinct allele and genotype frequencies, the negative association with GC is, however, consistent among different populations.…”

“…To date, although multiple studies have been conducted on association of IL4-590 C>T (Loh et al, 2009;Sugimoto et al, 2010;Zhang et al, 2013) and IL8-251 T>A (Gianfagna et al, 2008;Gao et al, 2010;Liu et al, 2010;Wang et al, 2010;Persson et al, 2011;Yuzhalin, 2011;Wang et al, 2012;Xue et al, 2012) and GC among Asians, Caucasians and Hispanics, results are hardly conclusive with evident variability according to race. Even within the Chinese population, studies report conflicting results among studies in Taiwan (Wu et al, 2003;Lai et al, 2005;Lee et al, 2005), Fujian (Lin, 2008), Hebei (Zhang et al, 2010), Beijing (Lu et al, 2005), Guangdong and Shanxi (Zeng et al, 2005) for each polymorphism. Noticing the variability of results, we considered that it was necessitated to initiate a study on IL4-590 C>T and IL8-251T>A for risk of GC in the southwestern region of China.…”

Cell proliferation-related genetic polymorphisms and gastric cancer risk: systematic review and meta-analysis

“…Our meta-analysis, which included two additional studies on this polymorphism, 19,21 confirmed associations to vary by population and histological type of GC. Significant heterogeneity was observed among all the included 14 studies on TP53 72Pro, with no evidence of an overall association with GC risk.…”

Genetic Factors Involved in the Genesis of Helicobacter Pylori-Induced Gastric Cancer

“…Usual case-control studies could provide the estimates for the final step (ie, literal carcinogenesis), when genotype frequency is different between gastric atrophy and gastric cancer, and the same among the uninfected, infected, and those with gastric atrophy. Table 5 lists the polymorphisms reported on gastric cancer risk, adopted from Gonzalez et al (Gonzalez et al, 2002) and recent studies (Ebert et al, 2005;Geddert et al, 2005;Li et al, 2005;Tsukino et al, 2002;Sugimoto et al, 2005;Gao et al, 2002;Wu et al, 2002;Goto et al, 2005;Lai et al, 2005a;Lee et al, 2004;Savage et al, 2004;Lai et al, 2005b;Lacasana-Navarro et al, 2006;Kim et al, 2005;Hamajima et al, 2002a;Duarte et al, 2005). The ORs are listed in case of being significant.…”