Association of genetic polymorphisms in chromosome 9p21 with risk of ischemic stroke

Han, Xuemei; Wang, Chunhui; Tang, Dongfang; Shi, Yuqing; Gao, Ming

doi:10.1016/j.cyto.2019.154921

Cited by 6 publications

(4 citation statements)

References 38 publications

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“…4 Moreover, it is reported that genetic factors play a role in the pathophysiological process of IS. Several studies had revealed a hereditary predisposition to IS susceptibility, such as polymorphisms in apolipoprotein E (APOE), ATP-binding cassette transporter 1 (ABCB1), and interferon-beta 1 (IFNB1), [5][6][7] but there are still many riskrelated genetic polymorphisms that have not been discovered. Wnt are a group of glycoproteins that play a key role in the proliferation, differentiation, and migration of adult neural stem/progenitor cells (NS/PC) in the central nervous system.…”

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Contribution of WNT2B Genetic Variants to Ischemic Stroke Occurrence in a Chinese Han Population

Yuan¹,

Fan²,

Yao

et al. 2021

Journal of Cardiovascular Pharmacology

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Contribution of WNT2B Genetic Variants to Ischemic Stroke Occurrence in a Chinese Han Population

Yuan¹,

Fan²,

Yao

et al. 2021

Journal of Cardiovascular Pharmacology

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“…In this meta-analysis, 18,584 participants were included: 14,033 in the IS group (7,235 cases with rs2383207, 3,762 cases with rs2383206, and 3,036 cases with rs10757278) and 14,656 cases in the control group (7,653 cases with rs2383207, 3,807 cases with rs2383206, and 3,196 cases with rs10757278). Eleven articles were selected, comprising 16 studies, of which six investigated rs2383207 ( Lin et al, 2011 ; Zhang et al, 2012 ; Li et al, 2017 ; Yang et al, 2018 ; Jin et al, 2021 ; Li et al, 2021 ), five investigated rs2383206 ( Ding et al, 2009 ; Hu et al, 2009 ; Zhang et al, 2012 ; Xiong et al, 2018 ; Li et al, 2021 ), and five investigated rs10757278 ( Ding et al, 2009 ; Zhang et al, 2012 ; Bi et al, 2015 ; Xiong et al, 2018 ; Han et al, 2020 ). The study identification and selection process is shown in detail in Figure 1 .…”

Section: Resultsmentioning

confidence: 99%

Association of Single-Nucleotide Polymorphisms of rs2383206, rs2383207, and rs10757278 With Stroke Risk in the Chinese Population: A Meta-analysis

Wang

Cui³

et al. 2022

Front. Genet.

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Several studies have reported that chromosome 9p21 is significantly associated with ischemic stroke (IS) risk, with the G allele associated with increased risk. However, controversial results have been reported in the literature. We systematically assessed the relationship between stroke and three 9p21 loci (rs2303206, rs2383207, and rs10757278) in this meta-analysis. First, we searched the PubMed and Embase databases for relevant studies. We then calculated odds ratios using the chi-squared test. The evaluation of experimental data was performed using bias tests and sensitivity analyses. We analyzed data from 16 studies involving 18,584 individuals of Chinese ancestry, including 14,033 cases and 14,656 controls. Our results indicated that chromosome 9p21 is significantly associated with IS (odds ratio: 1.15, 95% confidence interval: 1.1–1.20, p < 0.0001). Because the three single-nucleotide polymorphisms (rs2383206, rs2383207, and 10757278) have a linkage disequilibrium relationship, all three may increase the risk of IS.

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“…The role of rs10757278 in IS was analyzed in 10 studies [ 20 , 23 , 24 , 27 , 28 , 30 , 35 , 36 , 40 , 42 ] involving 9,352 cases and 2, 4552 controls. A positive association was found in the whole studied population, and in Asians and Caucasians with IS using the combined results.…”

Section: Resultsmentioning

confidence: 99%

Genetic association of ANRIL with susceptibility to Ischemic stroke: A comprehensive meta-analysis

et al. 2022

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Background Ischemic stroke (IS) is a complex polygenic disease with a strong genetic background. The relationship between the ANRIL (antisense non-coding RNA in the INK4 locus) in chromosome 9p21 region and IS has been reported across populations worldwide; however, these studies have yielded inconsistent results. The aim of this study is to clarify the types of single-nucleotide polymorphisms on the ANRIL locus associated with susceptibility to IS using meta-analysis and comprehensively assess the strength of the association. Methods Relevant studies were identified by comprehensive and systematic literature searches. The quality of each study was assessed using the Newcastle-Ottawa Scale. Allele and genotype frequencies were extracted from each of the included studies. Odds ratios with corresponding 95% confidence intervals of combined analyses were calculated under three genetic models (allele frequency comparison, dominant model, and recessive model) using a random-effects or fixed-effects model. Heterogeneity was tested using the chi-square test based on the Cochran Q statistic and I2 metric, and subgroup analyses and a meta-regression model were used to explore sources of heterogeneity. The correction for multiple testing used the false discovery rate method proposed by Benjamini and Hochberg. The assessment of publication bias employed funnel plots and Egger’s test. Results We identified 25 studies (15 SNPs, involving a total of 11,527 cases and 12,216 controls maximum) and performed a meta-analysis. Eight SNPs (rs10757274, rs10757278, rs2383206, rs1333040, rs1333049, rs1537378, rs4977574, and rs1004638) in ANRIL were significantly associated with IS risk. Six of these SNPs (rs10757274, rs10757278, rs2383206, rs1333040, rs1537378, and rs4977574) had a significant relationship to the large artery atherosclerosis subtype of IS. Two SNPs (rs2383206 and rs4977574) were associated with IS mainly in Asians, and three SNPs (rs10757274, rs1333040, and rs1333049) were associated with susceptibility to IS mainly in Caucasians. Sensitivity analyses confirmed the reliability of the original results. Ethnicity and individual studies may be the main sources of heterogeneity in ANRIL. Conclusions Our results suggest that some single-nucleotide polymorphisms on the ANRIL locus may be associated with IS risk. Future studies with larger sample numbers are necessary to confirm this result. Additional functional analyses of causal effects of these polymorphisms on IS subtypes are also essential.

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Association of genetic polymorphisms in chromosome 9p21 with risk of ischemic stroke

Cited by 6 publications

References 38 publications

Contribution of WNT2B Genetic Variants to Ischemic Stroke Occurrence in a Chinese Han Population

Contribution of WNT2B Genetic Variants to Ischemic Stroke Occurrence in a Chinese Han Population

Association of Single-Nucleotide Polymorphisms of rs2383206, rs2383207, and rs10757278 With Stroke Risk in the Chinese Population: A Meta-analysis

Genetic association of ANRIL with susceptibility to Ischemic stroke: A comprehensive meta-analysis

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