Association of Genetic Polymorphism of IL-2 Receptor Subunit and Tuberculosis Case

Lee, Sang-In; Jin, Hyun‐Seok; Park, Sangjung

doi:10.15616/bsl.2018.24.2.94

Cited by 4 publications

(2 citation statements)

References 21 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…It is suggested that sIL-2R together with IFN-γ and neopterin may serve as parameters to monitor the prognosis of TB, particularly in patients with severe pulmonary TB [49]. IL-2R gene polymorphism analysis including variants of IL-2RA, IL-2RB, and IL-2RG revealed that only IL-2RA gene polymorphisms showed a statistically significant association with susceptibility to TB [50]. In the study involving 235 participants with TB and latent Mtb infection, serum levels of IL-2Ra and chemokine CCL1 were higher in TB compared to latently infected individuals; therefore, they can be used as a diagnostic tool to discriminate between these groups [51].…”

Section: Il-2 Receptor (Il-2r)mentioning

confidence: 99%

Cytokine Receptors—Regulators of Antimycobacterial Immune Response

Druszczyńska

Godkowicz

Kulesza

et al. 2022

IJMS

View full text Add to dashboard Cite

Cytokine receptors are critical regulators of the antimycobacterial immune response, playing a key role in initiating and coordinating the recruitment and activation of immune cells during infection. They recognize and bind specific cytokines and are involved in inducing intracellular signal transduction pathways that regulate a diverse range of biological functions, including proliferation, differentiation, metabolism and cell growth. Due to mutations in cytokine receptor genes, defective signaling may contribute to increased susceptibility to mycobacteria, allowing the pathogens to avoid killing and immune surveillance. This paper provides an overview of cytokine receptors important for the innate and adaptive immune responses against mycobacteria and discusses the implications of receptor gene defects for the course of mycobacterial infection.

show abstract

Section: Il-2 Receptor (Il-2r)mentioning

confidence: 99%

Cytokine Receptors—Regulators of Antimycobacterial Immune Response

Druszczyńska

Godkowicz

Kulesza

et al. 2022

IJMS

View full text Add to dashboard Cite

show abstract

“…특히 ARMC4 유전자는 심 장 질환과의 연관을 조사한 연구들이 많이 존재하고 있 지 않으므로, 실험을 통하여 ARMC4와 심장 질환과의 연 관성을 확인한다면 더욱 확실한 연구가 될 것이다. 현재까지 다양한 질환의 발병과 환경적 및 유전적 요 인과의 상관관계에 대한 연구들이 진행되어 왔으며(Lee et al, 2018;Jeon and Jin, 2019;Lim et al, 2019) 고혈압에 관 련된 유전적 요인에 대한 연구들도 진행되어 왔다(Fowdar et al, 2017; Ko and Jin, 2019;Park et al, 2019). 본 연구에서 는 한국인 유전체 역학 자료를 기반으로 ARMC4, LRP4 그리고 BCL2 유전자의 유전적 변이들과 고혈압 및 혈압 수치와의 상관성을 분석하여 유의한 상관관계를 확인하 였다.…”

unclassified

Genetic Polymorphisms ofARMC4, LRP4andBCL2Genes are Associated with Blood Pressure Traits and Hypertension in Korean Population

Park

Jeon

Kim

et al. 2020

BSL

Self Cite

View full text Add to dashboard Cite

High blood pressure (HTN) is a condition in which blood pressure is kept higher than normal. Blood pressure trait measures systolic blood pressure (SBP) which is the highest pressure and diastolic blood pressure (DBP) which is the lowest blood pressure. Pulse pressure (PP) is the difference between systolic and diastolic blood pressure. Hypertension is known as a disease caused by the interaction of the environment and genetic factors. To date, studies have been conducted to find genes associated with hypertension. Genome-Wide Association Study (GWAS) analysis using European data from the UK Biobank reported new 535 loci were associated with blood pressure trait. Among them, 12 genes have been reported to have a significant correlation with SBP, DBP and PP. In the study, 12 genes polymorphisms were extracted based on KARE (Korean association resource) and then we performed linear regression of blood pressure trait. As a result, 6 SNPs of the 3 genes (rs12355413 and rs11006736 of ARMC4, rs2290883, rs2290884 and rs11039014 of LRP4, rs7234941 of BCL2) showed statistically significant correlation (P<0.05) with blood pressure trait. Of the 3 genes, 6 SNPs in 2 genes (rs9651357, rs12355413, rs11006736, rs1889522 of ARMC4 and rs4987774, rs7234941 of BCL2) showed significant correlation with hypertension. These results suggest that genetic polymorphisms of ARMC4, LRP4 and BCL2 genes are associated with blood pressure traits and hypertension in Korean population. Moreover, we expected to help understand the pathogenesis of hypertension.

show abstract

Genetic Polymorphisms ofSLC8A1Are Associated with Hypertension and Left Ventricular Hypertrophy in the Korean Population

Park

Kim

Jin

2019

Korean J Clin Lab Sci.

Self Cite

View full text Add to dashboard Cite

Hypertension (HTN) is one of the major chronic diseases, and HTN is defined as being in a state of continuous high blood pressure. Left ventricular hypertrophy (LVH) is a condition in which the mass of the left ventricle has increased, and HTN is a leading cause of LVH. HTN and LVH are known to be caused by the interaction of environmental factors and genetic factors. It has been reported that the polymorphisms of SLC8A1, among the genetic factors that affect high blood pressure, are related to salt sensitivity hypertension. In this study, the genetic polymorphisms of SLC8A1 were chosen based on the Korean Genome and Epidemiology data. Logistic regression analysis was then performed for HTN and LVH. Linear regression analysis was also performed for systolic blood pressure (SBP) and diastolic blood pressure (DBP). As a result, 5 SNPs showed statistically significant associations (P＜0.05) with HTN, and 10 SNPs showed statistically significant associations with LVH. rs1002671 and rs9789739 showed significant correlation at the same time with HTN and LVH. These results suggest that the polymorphisms of the SLC8A1 gene are linked to the development of HTN and LVH in Koreans. We expect these results to help us understand the pathogenic mechanisms for HTN and LVH. Candidate gene analysisHypertension Left ventricular hypertrophy SLC8A1 SNP 서 론 고혈압(hypertension, HTN)은 지속적으로 혈압이 높은 상 태를 의미하는 것으로 주요한 만성질환 중 한 가지이다. 이렇게 혈압이 높은 상태를 유지하게 되면 좌심실 비대, 가슴막 손상 기 능 장애, 승모판 역류 등을 포함한 고혈압에 의한 심장질환을 유 발하는 주요한 원인이 된다. 이러한 변화는 심방세동과 심실 부 정맥과 같은 부정맥으로 이어지며 급성심장사(sudden cardiac death, SCD)의 위험인자로도 알려져 있다[1]. 고혈압은 다양한 환경적 및 유전적 위험 인자들의 상호 작용으로 발생하는 질환 으로 잘 알려져 있는데, 환경적인 요인뿐만 아니라 고혈압에 영 향을 미치는 유전적 요인에 대한 연구도 활발하게 진행되고 있 다[2-4]. 특히 일반적인 고혈압에 비하여 염분에 대해 민감하게 증가하는 고혈압(salt sensitive hypertension)은 심혈관 질환 발병의 증가와 생존율 감소와 관련이 있는 것으로 밝혀졌다[5]. 좌심실 비대(left ventricular hypertrophy, LVH)는 심근세 Korean J Clin Lab Sci. 2019;51(3):286-293

show abstract

Association of Genetic Polymorphism of IL-2 Receptor Subunit and Tuberculosis Case

Cited by 4 publications

References 21 publications

Cytokine Receptors—Regulators of Antimycobacterial Immune Response

Cytokine Receptors—Regulators of Antimycobacterial Immune Response

Genetic Polymorphisms ofARMC4, LRP4andBCL2Genes are Associated with Blood Pressure Traits and Hypertension in Korean Population

Genetic Polymorphisms ofSLC8A1Are Associated with Hypertension and Left Ventricular Hypertrophy in the Korean Population

Contact Info

Product

Resources

About