Cytokine Receptors—Regulators of Antimycobacterial Immune Response

Druszczyńska, Magdalena; Godkowicz, Magdalena; Kulesza, Jakub; Wawrocki, Sebastian; Fol, Marek

doi:10.3390/ijms23031112

Cited by 14 publications

(14 citation statements)

References 175 publications

(208 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…aureus was the most common isolate in the current investigation (76.33%), in contrast to a recent study in Ethiopia that found Klebsiella species to be the most common bacteria (23.9%), followed by Proteus species (18.47%) (17/92) [39]. P. mirabilis (16.8%) is the most prevalent isolate in Egypt [40], Pseudomonas species (15.6%) in Saudi Arabia (n = 134) (27), and Pseudomonas species (18.8%) in South America [41].…”

Section: Discussioncontrasting

confidence: 71%

Microbiological Detection of Some Pathogenic Bacteria in Diabetic Foot Ulcers of Type 1 and 2 Diabetic Mellitus Patients

Marwah M. AL-Sahi,

May Mohammed Ali,

Sawsan M. Jabbar AL-Hasnawi

2023

UTJsci

View full text Add to dashboard Cite

Globally, diabetes mellitus (DM) is a serious health issue. Diabetic neuropathy, the most prevalent micro-vascular consequence of diabetes, raises the chance of developing foot ulcers. Different aerobic bacteria, including Gram positive cocci, Staphylococcus aureus, and (beta-haemolytic) Streptococcus are some of the pathogens that can colonize DFUs. Coagulation-negative Staphylococcus (CNS), Corynebacterium, Enterococcus, and Cutibacteria are frequently found in ulcer cultures in clinical practice; however they are typically regarded as colonizing rather than harmful bacteria. Anaerobes are detected in a smaller minority of DFIs and have been associated to altered innate and adaptive immune responses in the hyperglycemic milieu. Gram-negative bacteria account for about one third of DFIs. About 70 participants in all, including 29 individuals with type 1 diabetes and 41 patients with type 2 diabetes who have diabetic foot ulcers. Scarping of ulcers takes place after regular saline wound cleansing to eliminate surface pollutants, and then exudate is sampled. Pus, or discharges from the base of the ulcer, are then submitted to the laboratory as quickly as possible using an aseptic approach. Then, the bacteria were inoculated onto various culture media, such as MacConkey and Blood agar as enrichment media, and incubated aerobically at 37°C for 24 hours to isolate aerobic bacteria. The following day, the bacteria were checked for growth, and a pure colony was then prepared. According to morphological, microscopic, and particular cards of the automated VITEK2 system, isolated bacteria were identified.

show abstract

Section: Discussioncontrasting

confidence: 71%

Microbiological Detection of Some Pathogenic Bacteria in Diabetic Foot Ulcers of Type 1 and 2 Diabetic Mellitus Patients

Marwah M. AL-Sahi,

May Mohammed Ali,

Sawsan M. Jabbar AL-Hasnawi

2023

UTJsci

View full text Add to dashboard Cite

show abstract

“…The essential involvement of STAT6 in regulating the polarization of M2 macrophages induced by IL-4 or IL-13 has been extensively reported [ 20 ]. In our study, we observed robust phosphorylation of STAT6 protein in response to IL-4 stimulation.…”

Section: Discussionmentioning

confidence: 99%

“…These results indicate that the activation of STAT6 may contribute to the growth and drug resistance of colorectal cancer. STAT6 signaling is primarily activated by IL-4 and IL-13, which are critical cytokines for M2 macrophage polarization [ 20 ]. When IL-4 or IL-13 binds to the receptor, Janus kinase (JAK) is phosphorylated.…”

Section: Introductionmentioning

confidence: 99%

23-Hydroxybetulinic acid attenuates 5-fluorouracil resistance of colorectal cancer by modulating M2 macrophage polarization via STAT6 signaling

Fan,

Cui,

Chen

et al. 2024

Cancer Immunol Immunother

View full text Add to dashboard Cite

Macrophage polarization is closely associated with the inflammatory processes involved in the development and chemoresistance of colorectal cancer (CRC). M2 macrophages, the predominant subtype of tumor-associated macrophages (TAMs) in a wide variety of malignancies, have been demonstrated to promote the resistance of CRC to multiple chemotherapeutic drugs, such as 5-fluorouracil (5-FU). In our study, we investigated the potential of 23-Hydroxybetulinic Acid (23-HBA), a significant active component of Pulsatilla chinensis (P. chinensis), to inhibit the polarization of M2 macrophages induced by IL-4. Our results showed that 23-HBA reduced the expression of M2 specific marker CD206, while downregulating the mRNA levels of M2 related genes (CD206, Arg1, IL-10, and CCL2). Additionally, 23-HBA effectively attenuated the inhibitory effects of the conditioned medium from M2 macrophages on apoptosis in colorectal cancer SW480 cells. Mechanistically, 23-HBA prevented the phosphorylation and nuclear translocation of the STAT6 protein, resulting in the inhibition of IL-10 release in M2 macrophages. Moreover, it interfered with the activation of the IL-10/STAT3/Bcl-2 signaling pathway in SW480 cells, ultimately reducing M2 macrophage-induced resistance to 5-FU. Importantly, depleting STAT6 expression in macrophages abolished the suppressive effect of 23-HBA on M2 macrophage polarization, while also eliminating its ability to decrease M2 macrophage-induced 5-FU resistance in cancer cells. Furthermore, 23-HBA significantly diminished the proportion of M2 macrophages in the tumor tissues of colorectal cancer mice, simultaneously enhancing the anti-cancer efficacy of 5-FU. The findings presented in this study highlight the capacity of 23-HBA to inhibit M2 macrophage polarization, a process that contributes to reduced 5-FU resistance in colorectal cancer.

show abstract

“…Immune cells comprise innate (dendritic (D) and natural killer (NK) cells and macrophages) and adaptive immune cells (T and B cells) ( 22 ). Immune molecules comprise membrane-type (such as T and B cell receptor (CR), adhesion and major histocompatibility complex (MHC) molecules and cytokine receptors) and secreted molecules (such as immunoglobulin, complement and cytokines) ( 23 , 24 ). The most important function of the innate immune system is to respond quickly to infection or inflammation and to recruit innate immune cells or activate complement via cytokines secreted by the injured site (such as ILs and chemokines) ( 25 ).…”

Section: Association Between the Immune System And Tumormentioning

confidence: 99%

Immunotherapy: A new target for cancer cure (Review)

et al. 2023

View full text Add to dashboard Cite

Cancer is the leading cause of death globally and there is a worldwide cancer epidemic. Immunotherapy has emerged as a promising anticancer therapy. In particular, oncolytic viruses destroy cancer cells without destroying normal tissue via viral self-replication and anti-tumor immune responses, showing potential for cancer therapy. The present review discusses the role of the immune system in the treatment of tumor. The strategies for treating tumors are briefly introduced from aspects of active immunization and passive immunotherapy and the dendritic cell vaccines and oncolytic viruses are highlighted, as well as use of blood group A antigen in the treatment of solid tumors.

show abstract

Cytokine Receptors—Regulators of Antimycobacterial Immune Response

Cited by 14 publications

References 175 publications

Microbiological Detection of Some Pathogenic Bacteria in Diabetic Foot Ulcers of Type 1 and 2 Diabetic Mellitus Patients

Microbiological Detection of Some Pathogenic Bacteria in Diabetic Foot Ulcers of Type 1 and 2 Diabetic Mellitus Patients

23-Hydroxybetulinic acid attenuates 5-fluorouracil resistance of colorectal cancer by modulating M2 macrophage polarization via STAT6 signaling

Immunotherapy: A new target for cancer cure (Review)

Contact Info

Product

Resources

About