Association of gene polymorphisms with coronary artery disease in low- or high-risk subjects defined by conventional risk factors

Hirashiki, Akihiro; Yamada, Yoshiji; Murase, Yosuke; Suzuki, Yoriyasu; Kataoka, Hirokatsu; Morimoto, Yoshihito; Tajika, Toru; Murohara, Toyoaki; Yokota, Mitsuhiro

doi:10.1016/s0735-1097(03)01062-3

Cited by 117 publications

(51 citation statements)

References 24 publications

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“…( 29,30 ) Finally, prior studies of MMP and TIMP genes studied populations of around one hundred ( 10,17,25 ), multiple hundreds ( 11,12,13,16,18,19,21 ), between 1,000-1,700 participants. ( 14,15,20,(22)(23)(24)27 ) While the current study of >5,000 patients did not replicate all of those prior studies' findings, it improved on their sample sizes by 3-to 50-fold. Evaluation of many thousands of patients, as in this study, should help to reduce the variability between study findings.…”

Section: Genetic and Allelic Heterogeneitycontrasting

confidence: 81%

“…While all studies of MMP-3 evaluated the 5A/ 6A promoter SNP, only two have evaluated other MMP-3 SNPs and in those the 5A/6A SNP was as good or better at risk stratification than the others. ( 22,23 ) Prior studies of MMP-3 have found increased risk associated with both the 5A ( 11,13,14,18,21,22 ) and the 6A ( 10,12,13,23,26,27 ) allele, or no association ( 19 ), but the phenotypes studied therein included MI ( 11,14,(21)(22)(23)27 ), CAD presence ( 23 ), CAD progression ( 10,12 ), coronary aneurysm ( 18 ), patient-reported symptoms and CAD history ( 19 ), cardiac events ( 13 ), and CAD score ( 14 ).…”

Section: Phenotype Selection and Definitionmentioning

confidence: 99%

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Multiple-polymorphism associations of 7 matrix metalloproteinase and tissue inhibitor metalloproteinase genes with myocardial infarction and angiographic coronary artery disease

Horne¹,

Camp²,

Carlquist³

et al. 2007

American Heart Journal

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Background-Single nucleotide polymorphisms (SNPs) in matrix metalloproteinase (MMP) genes may be associated with myocardial infarction (MI) and coronary artery disease (CAD), but studies of multiple MMP genes and their tissue inhibitors (TIMPs) are scarce. Further, differentiation of predictive ability by endpoint (MI vs. CAD) has not been addressed. This study evaluated the association with MI of SNPs in genes encoding MMPs 1, 2, 3, and 9 and TIMPs 1, 2, and 3.

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Section: Genetic and Allelic Heterogeneitycontrasting

confidence: 81%

Section: Phenotype Selection and Definitionmentioning

confidence: 99%

Multiple-polymorphism associations of 7 matrix metalloproteinase and tissue inhibitor metalloproteinase genes with myocardial infarction and angiographic coronary artery disease

Horne¹,

Camp²,

Carlquist³

et al. 2007

American Heart Journal

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“…27 The T allele of this polymorphism was also shown to be a risk factor for coronary heart disease in low-risk Japanese men. 28 Our results now show that the T allele of this polymorphism was a risk factor for CKD.…”

Section: Discussionsupporting

confidence: 52%

Association of candidate gene polymorphisms with chronic kidney disease in Japanese individuals with hypertension

et al. 2009

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Although hypertension has been recognized as a risk factor for chronic kidney disease (CKD), the genetic factors for predisposition to CKD in individuals with hypertension remain largely unknown. The purpose of this study was to identify the genetic variants that confer susceptibility to CKD among individuals with hypertension. The study population comprised 3696 Japanese individuals with hypertension (2265 men, 1431 women), including 1257 individuals (789 men, 468 women) with CKD (estimated glomerular filtration rate (eGFR) o60 ml min À1 per 1.73 m 2 ) and 2439 controls (1476 men, 963 women; eGFRX60 ml min À1 per 1.73 m 2 ). The genotypes for 30 polymorphisms of 26 candidate genes were determined. An initial screening of allele frequencies by the v 2 -test revealed that eight polymorphisms were significantly (false discovery rate o0.05) associated with the prevalence of CKD in hypertensive individuals. Subsequent multivariable logistic regression analysis with adjustment for covariates as well as a stepwise forward selection procedure revealed that the T-C (Val591Ala) polymorphism of APOB (rs679899), the À681C-G polymorphism of PPARG (rs10865710), the T-C (Cys1367Arg) polymorphism of WRN (rs1346044), the À850C-T polymorphism of TNF (rs1799724), the À219G-T polymorphism of APOE (rs405509), the C-T polymorphism of PTGS1 (rs883484) and the 41A-G (Glu14Gly) polymorphism of ACAT2 (rs9658625) were significantly (Po0.05) associated with the prevalence of CKD. Our results suggest that APOB, WRN, ACAT2, APOE, PPARG, TNF and PTGS1 are susceptibility loci for CKD among Japanese individuals with hypertension. Determination of the genotypes for these polymorphisms may prove informative for the assessment of genetic risk for CKD among such individuals.

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“…Arg/Pro allele frequency among CAD and control subjects. probability of developing CAD (42,43). In this regard, genetic polymorphisms of the TP53 gene have been studied in CAD; however the results have so far been inconclusive (31,35,44).…”

Section: Discussionmentioning

confidence: 99%

TP53 single nucleotide polymorphism (rs1042522) in Iranian patients with coronary artery disease

et al. 2018

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Abstract. Chronic diseases including coronary artery disease (CAD) impose a high burden in terms of mortality and disability particularly in developing countries. Both genetic and environmental risk factors confer susceptibility to CAD. Meanwhile, a functional polymorphism in the tumor protein p53 (TP53) gene (codon 72, exon 4) has been reported to be associated with a wide range of cancers and inflammatory disorders. There are controversies regarding CAD and involvement of the TP53 codon 72 single nucleotide polymorphism; therefore, the present case-control study was conducted to evaluate the potential association between this TP53 polymorphism and CAD in an Iranian population. A total of 153 subjects (including 70 patients diagnosed with CAD and 83 subjects with normal coronary parameters, determined by angiography) were genotyped for the TP53 (rs1042522) polymorphism by the polymerase chain reaction-restriction fragment length polymorphism technique. Clinical and laboratory findings were also evaluated. The χ 2 test and unpaired Student's t-test were applied to compare genotype and allele distributions and clinical characteristics between the two groups. Significant associations of the Pro72 allele [odds ratio (OR)=1.66, P=0.027] and Pro/Pro genotype (OR=2.91, P=0.022) with CAD were identified. No associations between patients' clinical findings and genotypes were apparent. Therefore, according to present findings, the TP53 Pro72 allele may be involved in the development of CAD along with conventional risk factors in patients from Northern Iran.

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Association of gene polymorphisms with coronary artery disease in low- or high-risk subjects defined by conventional risk factors

Abstract: Genotyping of these polymorphisms may prove informative for assessment of the genetic risk of CAD in low- or high-risk men or women.

Cited by 117 publications

References 24 publications

Multiple-polymorphism associations of 7 matrix metalloproteinase and tissue inhibitor metalloproteinase genes with myocardial infarction and angiographic coronary artery disease

Multiple-polymorphism associations of 7 matrix metalloproteinase and tissue inhibitor metalloproteinase genes with myocardial infarction and angiographic coronary artery disease

Association of candidate gene polymorphisms with chronic kidney disease in Japanese individuals with hypertension

TP53 single nucleotide polymorphism (rs1042522) in Iranian patients with coronary artery disease

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