Association of Fc gamma-receptors IIa, IIIa, and IIIb genetic polymorphism with susceptibility to chronic periodontitis in South Indian population

Abstract

Background and Objective:Fc gamma receptors (FcγRs) are the members of the immunoglobulin superfamily and may play a role in the pathogenesis of periodontitis. Genetic variation in these receptors and its link with various forms of periodontitis is being studied in different populations. The aim of the present study is to determine whether specific FcγRIIa, FcγRIIIa, and FcγRIIIb alleles and/or genotypes are associated with risk for susceptibility to generalized chronic periodontitis (GCP) in South Indian population.Materials and Methods:The study population consisted of 120 South Indian subjects; 60 with GCP and 60 periodontally healthy. Deoxyribonucleic acid (DNA) was extracted from samples collected by scrapping buccal epithelium. FcγRIIa and FcγRIIIa genotyping were performed by polymerase chain reaction (PCR) amplification of DNA with allele-specific primers followed by allele-specific restriction digestion of the products. However, FcγRIIIb genotyping was done by allele-specific PCR.Results:No significant difference in the distribution of FcγRIIa H/R and FcγRIIIa NA1/NA2 genotypes or their respective alleles was observed in GCP patients and healthy subjects. For FcγRIIIa F/V genetic polymorphism, the homozygous V/V genotype and V allele were significantly overrepresented in GCP patients while F/F genotype and F allele in controls.Conclusion:The present study demonstrates that FcγRIIIa V/V genotype, as well as V allele, could be a possible risk factor for chronic periodontitis in South Indian population.

Polymorphisms in Genes Involved in Inflammation and Periodontitis: A Narrative Review

“…There was no correlation between the presence of this polymorphism and the occurrence of aggressive periodontitis in Taiwanese patients or in Caucasian patients [13]. In addition, no relationship was observed between the presence of the NA2 allele and the occurrence of chronic periodontitis in Japanese [12,35], Taiwanese or Caucasian patients [13]. On the other hand, more frequent occurrence of the NA2 allele was found in Japanese patients with recurring chronic periodontitis [12], and in the case of smoking patients, with the NA2 allele, faster disease progression was observed than in those who did not have the allele and to non-smoking patients with the NA2 allele [40].…”

“…The occurrence of these polymorphisms was evaluated in relation to periodontitis. In the case of FcγRIla, for which R131 and H131 alleles were identified, studies of Japanese patients did not show differences in the occurrence of individual alleles between patients with chronic [12,35] and aggressive periodontitis [36], on the one hand, and the control population on the other hand. In the Taiwanese population, however, the R131 allele was more common in patients with aggressive periodontitis compared to chronic inflammation.…”

“…In addition, no relationship was observed between the presence of the NA2 allele and the occurrence of chronic periodontitis in Japanese [12,35], Taiwanese or Caucasian patients [13]. On the other hand, more frequent occurrence of the NA2 allele was found in Japanese patients with recurring chronic periodontitis [12], and in the case of smoking patients, with the NA2 allele, faster disease progression was observed than in those who did not have the allele and to non-smoking patients with the NA2 allele [40]. The NA1 allele, in turn, was found much more frequently among elderly subjects resistant to periodontitis [14].…”

“…Attention was paid to the fact that the distribution of polymorphisms varies significantly in different populations [6]; therefore, results obtained in one population cannot be directly transferred to another one. With regard to both chronic and aggressive periodontitis, research focused on the polymorphisms of protein-coding genes involved in the inflammatory process and in the immune response, including histocompatibility antigens [9,10], IgG class antibodies [11] and their receptors [12][13][14], as well as CD14 molecules [15,16], toll-like receptors [17], vitamin D receptors [18] and other cellular receptors [19][20][21]. Polymorphisms of genes encoding metalloproteinases [22] and other enzymes [23] have also been studied.…”

The Genetic Aspects of Periodontitis Pathogenesis and the Regenerative Properties of Stem Cells

“…Furthermore, many polymorphisms in genes encoding the FcγRIla, FcγRIIIa, and FcγRIIIb subgroups may affect patients' susceptibility to periodontal illnesses [74]. For FcγRIla, two alleles were responsible for expression, R131 and H131, which showed a variable occurrence in patients with AP or CP depending on the examined ethnic population [91]. Another polymorphism involves the NA1 and NA2 alleles for FcγRIIIb [74].…”