Association of extracellular superoxide dismutase (SOD3) Ala40Thr gene polymorphism with pre-eclampsia complicated by severe fetal growth restriction

Rosta, Klára; Molvarec, Attila; Énzsöly, Anna; Nagy, Béla; Rónai, Zsolt; Fekete, Andrea; Sasvári-Székely, Mária; Rigó, János; Vér, Ágota

doi:10.1016/j.ejogrb.2008.10.014

Cited by 39 publications

(24 citation statements)

References 26 publications

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“…Several genetic, behavioural and environmental factors need to interact to produce the complete picture of this pregnancyspecific disorder. Our research group reported various genetic and soluble factors that were associated with the severity or complications of preeclampsia (Molvarec et al 2007, Molvarec et al 2008, Molvarec et al 2009b, Rosta et al 2009). …”

Section: Discussionmentioning

confidence: 88%

Increased circulating interleukin-17 levels in preeclampsia

Molvarec

Czegle

Szijártó³

et al. 2015

Journal of Reproductive Immunology

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Increasing evidence suggests that an exaggerated maternal systemic inflammatory response, as well as an angiogenic imbalance plays a central role in the pathogenesis of preeclampsia. In this study, we determined circulating levels of interleukin-17 (IL-17) along with those of angiogenic factors in healthy non-pregnant and pregnant women and preeclamptic patients, and examined whether serum IL-17 levels of preeclamptic patients were related to their clinical features and angiogenic factor concentrations. Fifty-nine preeclamptic patients, 60healthy pregnant women and 56 healthy non-pregnant women were involved in this casecontrol study. Serum levels of IL-17A were measured by high sensitivity ELISA. Serum total soluble fms-like tyrosine kinase-1 (sFlt-1) and biologically active placental growth factor (PlGF) levels were determined by electrochemiluminescence immunoassay. For statistical analyses, non-parametric methods were applied. Serum IL-17 levels were significantly higher in preeclamptic patients than in healthy non-pregnant and pregnant women. We did not find any relationship between serum IL-17 concentrations of preeclamptic patients and their clinical features and serum sFlt-1 and PlGF levels or sFlt-1/PlGF ratios. However, elevated serum IL-17 level and sFlt-1/PlGF ratio was found to be additive for the risk of preeclampsia, as shown by the substantially higher odds ratios of their combination than of either alone. In conclusion, serum IL-17 levels are increased in preeclampsia, which might contribute to the development of the excessive systemic inflammatory response characteristic of the maternal syndrome of the disease. In addition, elevated serum IL-17 level and sFlt-1/PlGF ratio had an additive (joint) effect in the risk of preeclampsia.

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Section: Discussionmentioning

confidence: 88%

Increased circulating interleukin-17 levels in preeclampsia

Molvarec

Czegle

Szijártó³

et al. 2015

Journal of Reproductive Immunology

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“…Increasing evidence suggests that an excessive maternal systemic inflammatory response to pregnancy with systemic oxidative stress and resultant endothelial damage plays a crucial role in the pathogenesis of the disease (2,3). The development of preeclampsia is influenced by both genetic and environmental risk factors, suggesting a multifactorial inheritance (4)(5)(6)(7)(8)(9).…”

Section: Introductionmentioning

confidence: 99%

Plasma osteopontin concentrations in preeclampsia – is there an association with endothelial injury?

Stenczer

Rigó

Prohászka

et al. 2009

Clinical Chemistry and Laboratory Medicine

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Background: It has been previously reported that plasma osteopontin (OPN) concentrations are increased in cardiovascular disorders. The goal of the present study was to determine plasma OPN concentrations in healthy pregnant women and preeclamptic patients, and to investigate their relationship to the clinical characteristics of the study subjects and to markers of inflammation wC-reactive protein (CRP)x, endothelial activation wvon Willebrand factor antigen (VWF:Ag)x or endothelial injury (fibronectin), oxidative stress wmalondialdehyde (MDA)x and trophoblast debris (cellfree fetal DNA). Methods: Forty-four patients with preeclampsia and 44 healthy pregnant women matched for age and gestational age were involved in this case-control study. Plasma OPN concentrations were measured with ELISA. Serum CRP concentrations were determined with an autoanalyzer using the manufacturer's reagents. Plasma VWF:Ag was quantified by ELISA, while plasma fibronectin concentrations were measured by nephelometry. Plasma MDA concentrations were estimated by the thiobarbituric acid-based colorimetric assay. The amount of cell-free fetal DNA in maternal plasma was determined by quantitative real-time PCR analysis of the sexdetermining region Y (SRY) gene. For statistical analyses, non-parametric methods were applied.

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“…Polymorphisms in the ecSOD gene have been linked to several diseases in humans, including type 2 diabetes, acute lung injury, ischemic heart disease, chronic obstructive pulmonary disease, and preeclampsia (52)(53)(54)(55)(56). However, the impact of ecSOD on the susceptibility of the human population to pathogenic infections has not been studied.…”

Section: Discussionmentioning

confidence: 99%

Extracellular Superoxide Dismutase Enhances Recruitment of Immature Neutrophils to the Liver

et al. 2016

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Listeria monocytogenes is a Gram-positive intracellular pathogen that causes spontaneous abortion in pregnant women, as well as septicemia, meningitis, and gastroenteritis, primarily in immunocompromised individuals. Although L. monocytogenes can usually be effectively treated with antibiotics, there is still around a 25% mortality rate with individuals who develop clinical listeriosis. Neutrophils are innate immune cells required for the clearance of pathogenic organisms, including L. monocytogenes. The diverse roles of neutrophils during both infectious and noninfectious inflammation have recently gained much attention. However, the impact of reactive oxygen species, and the enzymes that control their production, on neutrophil recruitment and function is not well understood. Using congenic mice with varying levels of extracellular superoxide dismutase (ecSOD) activity, we have recently shown that the presence of ecSOD decreases clearance of L. monocytogenes while increasing the recruitment of neutrophils that are not protective in the liver. The data presented here show that ecSOD activity does not lead to a cell-intrinsic increase in neutrophil-homing potential or a decrease in protection against L. monocytogenes. Instead, ecSOD activity enhances the production of neutrophil-attracting factors and protects hyaluronic acid (HA) from damage. Furthermore, neutrophils from the livers of ecSOD-expressing mice have decreased intracellular and surface-bound myeloperoxidase, are less capable of killing phagocytosed L. monocytogenes, and have decreased oxidative burst. Collectively, our data reveal that ecSOD activity modulates neutrophil recruitment and function in a cell-extrinsic fashion, highlighting the importance of the enzyme in protecting tissues from oxidative damage. Listeria monocytogenes is a Gram-positive bacterium that can be found in the soil, fruits, vegetables, meats, and dairy products. Ingestion of L. monocytogenes-contaminated foods can cause spontaneous abortions in pregnant women, as well as septicemia, meningitis, and gastroenteritis, primarily in immunocompromised individuals (1). Surprisingly, clinical listeriosis results in an ϳ25% mortality rate despite the use of antibiotics (1), which makes understanding the immune response against the pathogen important. Furthermore, L. monocytogenes is a widely used model pathogen to study and understand host-pathogen interactions due to its ease of use and manipulation.Neutrophils are short-lived immune cells that differentiate in the bone marrow from the common myeloid progenitor (2). Under normal homeostatic conditions, most neutrophils are retained in the bone marrow until inflammation leads to signaling for their egress. One of the mechanisms by which neutrophils are recruited out of the bone marrow and into tissues is through the increased production of CXCL1 and CXCL2 (3, 4), which are both induced by the interleukin 23 (IL-23)/IL-17 pathway (5, 6). During lipopolysaccharide (LPS)-induced hepatic injury, hyaluronic acid (HA)-CD44 interactions faci...

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Association of extracellular superoxide dismutase (SOD3) Ala40Thr gene polymorphism with pre-eclampsia complicated by severe fetal growth restriction

Cited by 39 publications

References 26 publications

Increased circulating interleukin-17 levels in preeclampsia

Increased circulating interleukin-17 levels in preeclampsia

Plasma osteopontin concentrations in preeclampsia – is there an association with endothelial injury?

Extracellular Superoxide Dismutase Enhances Recruitment of Immature Neutrophils to the Liver

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