Association of extracellular acetylcholinesterase with gustatory nerve terminal fibers in the nucleus of the solitary tract

Barry, Michael A.; Haglund, Stacey; Savoy, Lawrence

doi:10.1016/s0006-8993(01)03066-9

Cited by 19 publications

(10 citation statements)

References 55 publications

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“…Studies in adult hamster show that injury to the chorda tympani nerve leads to degeneration within the area of NTS where the nerve forms its terminal field (Barry, 1999; Barry and Frank, 1992; Whitehead et al, 1995), loss of acetylcholinesterase staining (Barry et al, 2001), and a reduction in functional responses to taste stimuli in the NTS at 8 weeks post-CTX (Barry, 1999). Barry (1999) also reported a significant decrease in hamster chorda tympani nerve terminal field density and in terminal field area; however, the region of interest was limited to a 30 μm × 30 μm square in the densest portion of the coronally sectioned terminal field and did not include the entire terminal field.…”

Section: Discussionmentioning

confidence: 99%

“…However, relatively few studies have focused on central changes induced by taste nerve injury at adulthood. Documented changes in the first central gustatory relay, the nucleus of the solitary tract (NTS), following nerve damage include long-term transganglionic degeneration (Barry, 1999; Barry and Frank, 1992; Whitehead et al, 1995), incomplete recovery of acetylcholinesterase staining (Barry and Frank, 1992; Barry et al, 2001), and functional taste alterations (Barry, 1999). Although these are pioneering studies, none has detailed the effects on the chorda tympani nerve terminal field that remained after nerve section or identified the upstream events that might underlie the central effects.…”

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confidence: 99%

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Impact of chorda tympani nerve injury on cell survival, axon maintenance, and morphology of the chorda tympani nerve terminal field in the nucleus of the solitary tract

Reddaway

Davidow

Deal

et al. 2012

J of Comparative Neurology

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Chorda tympani nerve transection (CTX) has been useful to study the relationship between nerve and taste buds in fungiform papillae. This work demonstrated that the morphological integrity of taste buds depends on their innervation. Considerable research focused on the effects of CTX on peripheral gustatory structures, but much less research has focused on the central effects. Here, we explored how CTX affects ganglion cell survival, maintenance of injured peripheral axons, and the chorda tympani nerve terminal field organization in the nucleus of the solitary tract (NTS). After CTX in adult rats, the chorda tympani nerve was labeled with biotinylated dextran amine at 3, 7, 14, 30, and 60 days post-CTX to allow visualization of the terminal field associated with peripheral processes. There was a significant and persistent reduction of the labeled chorda tympani nerve terminal field volume and density in the NTS following CTX. Compared with controls, the volume of the labeled terminal field was not altered at 3 or 7 days post-CTX; however, it was significantly reduced by 44% and by 63% at 30 and 60 days post-CTX, respectively. Changes in the density of labeled terminal field in the NTS paralleled the terminal field volume results. The dramatic decrease in labeled terminal field size post-CTX cannot be explained by a loss of geniculate ganglion neurons or degeneration of central axons. Instead, the function and/or maintenance of the peripheral axonal process appear to be affected. These new results have implications for long-term functional and behavioral alterations.

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Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

Impact of chorda tympani nerve injury on cell survival, axon maintenance, and morphology of the chorda tympani nerve terminal field in the nucleus of the solitary tract

Reddaway

Davidow

Deal

et al. 2012

J of Comparative Neurology

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“…Uteshev and Smith, 2006). Although the region of the NST in which afferent terminals of the VII and IX nerves are most dense is heavily immunoreactive for the presence of acetylcholinesterase, (AChE; (Barry et al, 1993(Barry et al, , 2001 it is not yet clear if or how cholinergic mechanisms modulate taste activity.…”

Section: Neurotransmitters and Neuromodulatorsmentioning

confidence: 99%

Neurochemistry of the Gustatory System

Smith

Boughter²

2006

Handbook of Neurochemistry and Molecular Neurobiology

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“…Despite screening on over 100 enzymes, receptors and ion channels (Hough, et al, 2001a), improgan’s biochemical target remains unknown. The drug does not require activity at supraspinal opioid (Hough, et al, 2000b), histamine (Mobarakeh, et al, 2003;Zhu, et al, 2001), adrenergic α 2 (Svokos, et al, 2001), nicotinic cholinergic, muscarinic cholinergic, 5HT 3 (Nalwalk, et al, 2005) or GABA A receptors (Cannon, et al, 2004). Extensive in vivo pharmacology has shown a non-opioid, cannabinoid-like antinociceptive profile, but improgan has no affinity for known cannabinoid receptors (Gehani, et al, 2007).…”

Section: Introductionmentioning

confidence: 99%

Efficacy of improgan, a non-opioid analgesic, in neuropathic pain

2011

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Improgan, a non-opioid analgesic, is known to act in the rodent brain stem to produce highly effective antinociception in several acute pain tests. However, improgan has not been studied in any models of chronic pain. To assess the efficacy of improgan in an animal model of neuropathic pain, the effects of this drug were studied on mechanical allodynia following unilateral spinal nerve ligation (SNL) in rats. Intracerebroventricular (icv) improgan (40 – 80 µg) produced complete, reversible, dose-dependent attenuation of hind paw mechanical allodynia for up to one hr after administration, with no noticeable behavioral or motor side effects. Intracerebral (ic) microinjections of improgan (5 – 30 µg) into the rostral ventromedial medulla (RVM) also reversed the allodynia, showing this brain area to be an important site for improgan’s action. The recently-demonstrated suppression of RVM ON-cell activity by improgan may account for the presently-observed anti-allodynic activity. The present findings suggest that brain-penetrating, improgan-like drugs developed for human use could be effective medications for the treatment of neuropathic pain.

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Association of extracellular acetylcholinesterase with gustatory nerve terminal fibers in the nucleus of the solitary tract

Cited by 19 publications

References 55 publications

Impact of chorda tympani nerve injury on cell survival, axon maintenance, and morphology of the chorda tympani nerve terminal field in the nucleus of the solitary tract

Impact of chorda tympani nerve injury on cell survival, axon maintenance, and morphology of the chorda tympani nerve terminal field in the nucleus of the solitary tract

Neurochemistry of the Gustatory System

Efficacy of improgan, a non-opioid analgesic, in neuropathic pain

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