Association of extent and infection of pancreatic necrosis with organ failure and death in acute necrotizing pancreatitis

Garg, Pramod Kumar; Madan, Kaushal; Pande, Girish; Khanna, Sudeep; Sathyanarayan, Garipati; Bohidar, Narendra Prasad; Tandon, Rakesh

doi:10.1016/s1542-3565(04)00665-2

Cited by 170 publications

(116 citation statements)

References 27 publications

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“…Approximately 10% of patients with interstitial pancreatitis experience organ failure, but in the majority it is transient with a very low mortality. Median prevalence of organ failure in necrotizing pancreatitis is 54% (range 29-78%) (31,50,54,82,83,120,147,148). Prevalence of organ failure is the same or somewhat higher in infected necrosis (34-89%) than in sterile necrosis (45-73%) (66,83,138,161).…”

Section: Overview Of Acute Pancreatitismentioning

confidence: 97%

“…However, the extent of necrosis may not be as important in the morbidity and mortality of necrotizing pancreatitis as was once thought. While some series have shown a correlation between extent of necrosis and prevalence of organ failure (66,69,148,161), others have not (50,83,111); similarly, while some series have shown a correlation between the extent of necrosis and the prevalence of infected necrosis (117,161,175), others have not (83,91,111); while one recent study has shown a correlation of extent of necrosis with mortality (161), others have not (83,128,138).…”

Section: Level Of Evidence: IIImentioning

confidence: 99%

See 1 more Smart Citation

Practice Guidelines in Acute Pancreatitis

Banks

Freeman

2006

Am J Gastroenterology

1,662

980

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Section: Overview Of Acute Pancreatitismentioning

confidence: 97%

Section: Level Of Evidence: IIImentioning

confidence: 99%

Practice Guidelines in Acute Pancreatitis

Banks

Freeman

2006

Am J Gastroenterology

1,662

980

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“…Infection of pancreatic necrosis is the most frequent cause of late mortality in severe acute pancreatitis [1][2][3]. Antibiotic prophylaxis to reduce infective complications in acute pancreatitis was evaluated in a series of randomized trials [4][5][6][7][8][9][10][11][12].…”

Section: Introductionmentioning

confidence: 99%

Antibiotic use in acute pancreatitis: An audit of current practice in a tertiary centre

et al. 2016

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“…In later stages, the majority of deaths are related to the infection of pancreatic necrosis. During this period, sepsis with consequent failure of multiple organs and systems (IMOS) is the leading cause of death, which occurs from the second and third weeks of onset 21,25,42 .…”

Section: Introductionmentioning

confidence: 99%

“…The same difficulty is found in the characterization of the existence of sterile/infected fluid collection and abscess, and abscess with pseudocyst. The evolution of organ dysfunction or IMOS and a positive aspiration, provide grants to characterize the presence of infection, pancreatic necrosis, collection or presence of abscess 16,25,59 .…”

Section: Introductionmentioning

confidence: 99%

Quando e como tratar as complicações na necrose pancreática infectada

Silva¹,

Pacheco-Junior²,

Moricz³

et al. 2010

ABCD, arq. bras. cir. dig.

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-Introduction -Acute pancreatitis is presented in its severe form between 10% and 15% of cases and is associated with high mortality. In the initial phase, evolution characterized by the onset of organ dysfunction and subsequently by the presence of pancreatic necrosis and its complications. Methods -It was performed a literature review with consultations in the following databases: PubMed, SciELO, Lilacs. Headings used were the following: acute pancreatitis, infection, pancreatic necrosis. Conclusion -The treatment of pancreatic necrosis, despite the advent of modern methods and techniques, is still challenging. Because of the multiplicity of aspects that may take the examination of each case, in view of the extent, severity and location of facilities within a patient's care, the treatment should be individualized for each case.RESUMO -Introdução -A pancreatite aguda se apresenta na sua forma grave entre 10% e 15% dos casos e está associada com alta mortalidade. Na fase inicial da evolução caracteriza-se pelo aparecimento de disfunções orgânicas e posteriormente pela presença de necrose pancreática e suas complicações. Método -Foi realizada revisão da literatura com consultas feitas nas seguintes bases de dados: Pubmed, Scielo, Lilacs. Os descritores cruzados foram os seguintes: pancreatite aguda, infecção, necrose pancreática. Conclusão -O tratamento da necrose pancreática, apesar do advento de modernos métodos e técnicas, ainda continua desafiador. Devido à multiplicidade de aspectos que pode assumir, a análise de cada caso, tendo em vista a extensão, gravidade e meios existentes no local de atendimento do paciente, é que deverá orientar o tratamento possível, sendo ele sempre individualizado a cada caso.

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Association of extent and infection of pancreatic necrosis with organ failure and death in acute necrotizing pancreatitis

Cited by 170 publications

References 27 publications

Practice Guidelines in Acute Pancreatitis

Practice Guidelines in Acute Pancreatitis

Antibiotic use in acute pancreatitis: An audit of current practice in a tertiary centre

Quando e como tratar as complicações na necrose pancreática infectada

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