Association of ETS1 polymorphism with granulomatosis with polyangiitis and proteinase 3-anti-neutrophil cytoplasmic antibody positive vasculitis in a Japanese population

Kawasaki, Aya; Yamashita, Katsushi; Hirano, Fumio; Sada, Ken‐ei; Tsukui, Daisuke; Kondo, Yuya; Kimura, Yoshitaka; Asako, Kurumi; Kobayashi, Shigeto; Yamada, Hisakata; Furukawa, Hiroshi; Nagasaka, Kenji; Sugihara, Takahiko; Yamagata, Kunihiro; Sumida, Takayuki; Tohma, Shigeto; Kono, Hajime; Ozaki, Shoichi; Matsuo, Seiichi; Hashimoto, Hiroshi; Makino, Hírofumi; Arimura, Yoshihiro; Harigai, Masayoshi; Tsuchiya, Naoyuki

doi:10.1038/s10038-017-0362-2

Cited by 17 publications

(10 citation statements)

References 36 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Among Han Chinese population, rs3117242 variant of HLA DPB1 allele was more common among GPA patients than controls . In Japanese population, rs1128334A polymorphism in ETS1 proto‐oncogene was found to be significantly higher in GPA patients and PR3 ANCA positive AAV patients . The geographical variations in the prevalence of the disease and the various organ manifestations could be explained based on genetic factors.…”

Section: Etiology and Pathogenesismentioning

confidence: 94%

Is granulomatosis with polyangiitis in Asia different from the West?

et al. 2018

View full text Add to dashboard Cite

The incidence and clinical features of antineutrophil cytoplasmic antibody (ANCA) associated vasculitis (AAV) have been shown to vary according to geographical areas, with granulomatosis with polyangiitis (GPA) being more common in northern Europe and microscopic polyangiitis (MPA) being more common in Asian countries.The annual incidence of GPA among Asians varies between 0.37/million to 2.1/million population. The prevalence of GPA has been estimated to be 1.94/100 000 in a Chinese population. Polymorphisms in class II major histocompatibility genes and ETS1 proto-oncogene has been shown in Asian patients with GPA. There is a difference in mean age at onset and proteinase 3 (PR3) or myeloperoxidase (MPO) positivity in GPA patients from different Asian countries. Those from India had mean age of 40 years and those from Japan had mean age of 65 years. Sixty percent of GPA patients from China and Japan were MPO ANCA positive while the majority of patients from India and Korea were PR3 positive. Geographical variation with lower frequency of renal involvement in Indian studies and higher frequency in Chinese patients has also been noted. Treatment outcomes have been similar to those reported from other parts of the world. Remission was achieved in about two-thirds of patients while relapses were noted in one-third to half of the patients. Apart from minor differences in the organ systems involved, MPO-ANCA GPA and PR3-ANCA GPA had similar rates of remission and relapses. K E Y W O R D S Asia, granulomatosis with polyangiitis, vasculitisWe searched PubMed using the search terms "Granulomatosis with polyangiitis", "GPA" and "Wegener's granulomatosis". We screened for articles published from Asian countries and describing the epidemiology, pathogenesis, clinical features and outcomes of GPA patients. Case reports and small case series of less than 5 patients were not included. The basis of diagnosis of GPA in different studies was either histopathology suggestive of GPA or fulfilling the American College of Rheumatology (ACR) criteria for GPA or classified according to European Medicines Evaluation Agency classification. We also included large case series on GPA from Europe and USA to compare them with Asian studies. | EPID EMIOLOGYThe incidence and prevalence of GPA shows a regional and ethnical difference with higher incidence of GPA in northern Europe and lower incidence in Asian countries. 1 The precise estimates of incidence and prevalence of AAV and GPA are not available from Asian countries. In the epidemiological study by Fujimoto et al, 1 the annual incidence of GPA in Japan was calculated to be 2.1/million population, which was much lower than that noted in the UK (annual incidence of 14.3/million). The annual incidence of MPA was higher in Japan than the UK and the overall incidence of all AAV was similar between Japan and the UK. Liu et al 7 used DIS-MOD II software to estimate prevalence based on the inpatient data of GPA patients in 100 hospitals across China. They estimated the prevalence of GPA to be 1...

show abstract

Section: Etiology and Pathogenesismentioning

confidence: 94%

Is granulomatosis with polyangiitis in Asia different from the West?

et al. 2018

View full text Add to dashboard Cite

show abstract

“…Cytoplasmic-pattern antineutrophil cytoplasmic autoantibodies (C-ANCA) with antigen specificity for proteinase 3 (PR3-ANCA) are sensitive serologic marker for GPA. ETS1 (ETS protooncogene 1) polymorphism was suggested to be associated with GPA and C-ANCA in Japanese population [62]. However, MPO-ANCA can be seen in 10-20% of patients in Europe and greater than 50% in Asia.…”

Section: Clinical Presentationmentioning

confidence: 99%

Vasculitis

Hoang

Park

2020

Hospital-Based Dermatopathology

View full text Add to dashboard Cite

“…[10][11][12][13] Cited prevalence rates (per million) include 23.7 in Paris; 14 30 in the United States; 15 95.1 in Norway; 12 112 in New Zealand; 16 and 160 in southern Sweden. 17 GPA affects predominantly Caucasians, 10,12 although cohorts in Korea, 18,19 Japan, 20,21 and China 22,23 have been published. The peak incidence is in the fourth through seventh decades of life; [6][7][8]15 children or adolescents are rarely affected.…”

Section: Epidemiologymentioning

confidence: 99%

Granulomatosis with Polyangiitis (Wegener's Granulomatosis): Evolving Concepts in Treatment

Lynch

Derhovanessian

Tazelaar

et al. 2018

Semin Respir Crit Care Med

View full text Add to dashboard Cite

Granulomatosis with polyangiitis (GPA), formerly termed Wegener's granulomatosis, is the most common of the pulmonary vasculitides. GPA typically involves the upper respiratory tract, lower respiratory tract (bronchi and lung), and kidney, with varying degrees of disseminated vasculitis. Cardinal histologic features include a necrotizing vasculitis involving small vessels, extensive “geographic” necrosis, and granulomatous inflammation. The spectrum and severity of the disease is heterogeneous, ranging from indolent disease involving only one site to fulminant, multiorgan vasculitis. Circulating antibodies against cytoplasmic components of neutrophils (ANCAs) play a role in the pathogenesis, and often correlate with activity of the disease. Treatment strategies are evolving. Cyclophosphamide (CYC) plus corticosteroids was the mainstay of therapy for generalized, multisystemic GPA since the 1970s. However, within the past decade, rituximab (RTX), a monoclonal antibody directed against B cells, has been shown to be at least as effective (and possibly more effective) as CYC. Furthermore, the use of RTX may reduce the need for maintenance immunosuppression. Optimal therapy for GPA remains controversial, and additional studies are required to determine the role and duration of maintenance therapy following successful induction therapy.

show abstract

Association of ETS1 polymorphism with granulomatosis with polyangiitis and proteinase 3-anti-neutrophil cytoplasmic antibody positive vasculitis in a Japanese population

Cited by 17 publications

References 36 publications

Is granulomatosis with polyangiitis in Asia different from the West?

Is granulomatosis with polyangiitis in Asia different from the West?

Vasculitis

Granulomatosis with Polyangiitis (Wegener's Granulomatosis): Evolving Concepts in Treatment

Contact Info

Product

Resources

About